Eicosanoid and Alkaloids, Serotonin, Histamine

Question 1

Histamine is formed from what AA?

Answer 1

Histidine

Question 2

What substance is measured in urine to detect excess production of Histamine?

Answer 2

Imidazole acetic acid

Question 3

Classic demonstration of Histamine effect

Answer 3

Wheal
flush
flare

Question 4

Histamine receptor in smooth muscles

Answer 4

H1

Question 5

Histamine receptor in stomach, heart, mast cells

Answer 5

H2

Question 6

1st generation anti-H1 receptors

Answer 6

Diphenhydramine 
Chlorpheniramine  
Cyclizine  
Meclizine 
Promethazine

Question 7

Difference between 1st gen and 2nd gen anti-H1

Answer 7

2nd gen has no autonomic or anti-motion sickness effects

Question 8

H2-receptor antagonists

Answer 8

Cimetidine
Ranitidine
Famotidine
Nizatidine

Question 9

Uses of Cimetidine

Answer 9

PUD
ZE syndrome
Gastroesophageal Reflux

Question 10

DOC for acute migraine

Answer 10

Sumatriptan

Question 11

Serotonin is produced from what AA

Answer 11

Tryptophan

Question 12

Excess 5-HT in the body is detected by what in the urine

Answer 12

5-hydroxyindole acetic acid

Question 13

5HT-1D/1B receptor agonists

Answer 13

Sumatriptan
Almotriptan
Eletriptan

Question 14

5-HT3-receptor antagonists

Answer 14

Ondasetron
Granisetron
Dolasetron

Question 15

Uses of Ondasetron

Answer 15

Chemotherapy and post-op vomiting

Question 16

Additional use of Alosetron

Answer 16

Irritable bowel disease

Question 17

5HT3-antagonist tha causes QRS and QT prolongation

Answer 17

Dolasetron

Question 18

5HT2 receptor antagonist

Answer 18

Ketanserin

Question 19

Vomiting center of the brain

Answer 19

Area postrema – floor of the 4th ventricle

Question 20

Classification of ergot alkaloids

Answer 20

Vasoselective
Uteroselective
CNS-Selective

Question 21

Vasoselective 5-HT2-receptor antagonist

Answer 21

Ergotamine

Methysergide

Question 22

Uteroselective 5-HT2-receptor antagonist

Answer 22

Ergonovine

Methyergonovine

Question 23

Causes marked smooth muscle contraction but blocks alpha-agonist vasoconstriction

Answer 23

Ergotamine

Ergonovine

Question 24

Important group of endogenous FA derivatives that are produced from arachidonic acid

Answer 24

Eicosanoids

Question 25

Straight-chain derivatives eicosanoids

Answer 25

Leukotrienes

Question 26

Cyclic derivatives eicosanoids

Answer 26

Prostacyclin Prostaglandins Thromboxane

Question 27

Inhibits Lipoxygenase

Answer 27

Zileuton

Question 28

Used in synthesis of prostacyclin in the vascular endothelium and of prostaglandins important in renal function

Answer 28

COX-2

Question 29

Leukocyte chemotaxis

Answer 29

LTB4

Question 30

Slow-reacting substance of anaphylaxis

Answer 30

LTC4, LTD4

Question 31

maintains PDA

Answer 31

PGE1

Question 32

Platelet aggregation

Answer 32

TXA2

Question 33

Exotropia, | Complete absence of facial expression

Answer 33

Moebius sequence – SE of Misoprostol

Question 34

Straight-chain derivatives eicosanoids

Answer 34

Leukotrienes

Question 35

Cyclic derivatives eicosanoids

Answer 35

Prostacyclin Prostaglandins Thromboxane

Question 36

Inhibits Lipoxygenase

Answer 36

Zileuton

Question 37

Used in synthesis of prostacyclin in the vascular endothelium and of prostaglandins important in renal function

Answer 37

COX-2

Question 38

Leukocyte chemotaxis

Answer 38

LTB4

Question 39

Slow-reacting substance of anaphylaxis

Answer 39

LTC4, LTD4

Question 40

maintains PDA

Answer 40

PGE1

Question 41

Platelet aggregation

Answer 41

TXA2

Question 42

Exotropia, | Complete absence of facial expression

Answer 42

Moebius sequence – SE of Misoprostol