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RUVM Pharmacology > Diuretics > Flashcards

Diuretics Flashcards

(46 cards)

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1
Q

Classes of Diuretics

A 
Osmotic
Loop
Thiazide 
Potassium sparing
Carbonic Anyhydrase Inhibitor
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2
Q

Main use of diurectics

A

Tx edema

Na excretion

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3
Q

Osmotic diurectic

A

Mannitol

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4
Q

MOA osmotic diurectic

A

Filtered by glomerules –> poorly absorbed –> increase water loss

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5
Q

Admin of Mannitol

A

IV only

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6
Q

Mannitol classify

A

Osmotic diuretic

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7
Q

What typ eof patient recieves mannitol

A

euhydrated patients!!! only

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8
Q

What is mannitol used to tx

A

TOC: cerebral edema

Tx glucoma

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9
Q

What drug is a loop diurectic

A

Furosemide

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10
Q

Where do loop diurectics function

A

Thick ascending loop of henle

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11
Q

What is the most effiecent diurectic

A

Loop –> FUROSEMIDE

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12
Q

What do loop diurectics inhibit

A

NaCl symporter

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13
Q

Loop diurectic MOA

A

Inhibit Na/K/Cl cotransporter at thick ascending loop of henle –> inhibits reabsorption of Ca & Mg–> Increases K & H+ loss

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14
Q

Furosemide MOA

A

Inhibit Na/K/Cl cotransporter at thick ascending loop of henle –> inhibits reabsorption of Ca & Mg–> Increases K & H+ loss

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15
Q

Furosemide & Ca

A

results in hypocalemia

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16
Q

Furosemide DOC

A

DOC: cardiogenic pulmonary edema due to CHF

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17
Q

Furosemide uses

A

DOC: cardiogenic pulmonary edema due to CHF

TX severe hypercalemia

TX exercise induced pulmonary bleeding in horses!

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18
Q

Cautions with Furosemide

A

hypocalemia
systemic metabolic alkalosis
most potent
cats are sensitive … shocker

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19
Q

Furosemide onset & duration

Study These Flashcards
A

Rapid onset

short duration

20
Q

What drug is an Thiazide diurectic

Study These Flashcards
A

Hydrocholorthiazide

21
Q

MOA of Thiazide

Study These Flashcards
A

Inhibition of NaCl sympoter on early DCT & CD

Increase absorption to Ca

Results in hypokalemia & systemic alkalosis

22
Q

Classify Hydrocholorthiazide

Study These Flashcards
A

Thiazide Diurectic

23
Q

Where does Hydrocholorthiazide act

Study These Flashcards
A

Early DCT & CD

24
Q

Hydrocholorthiazide uses?

Study These Flashcards
A

Adjunct cardiogenic pulmonary edema due to CHF
TX hypertension
TX nephrogenic diabetes insipidus
TX Ca Nephrolithiasis

25
What Diurectic can help nephrogenic diabetes insipdus
Hydrochlorothiazide
26
What diurectic can tx hypertension
Hydrochlorothiazide
27
What diurectic can tx Ca nephrolitastsis
Hydrochlorothiazide
28
Do not use Hydrochlorothiazide in paitent with
Pre-existing hypercalemia
29
How is Furosemide different than Hydrochlorothiazide regarding Ca
Hydrochlorothiazide --> increases Ca but does not result in hypercalemia Furosemide --> tx of hypercalemia
30
What is the end result of hydrochlorothiazide
hypokalemia | systemic alkalosis
31
What is the potassium sparing diurectic
Spironolactone
32
MOA of Potassium sparing diurectics
Competitive antagonism of Aldosterone in late DCT & CD Retention of K & H
33
Spironolactone MOA
Competitive antagonism of Aldosterone in late DCT & CD Retention of K & H
34
Spironolactone uses
Tx hyperaldosteronism Adjucant diuretic of edema or ascites
35
What diurectic can help with hyperaldosteonism
Spironolactone
36
Cautions of Spironolactone
Hyperkalemia | systemic acidosis
37
What diurectic is an Carbonic Anhydrase Inhibitor
Acetazolamide
38
MOA of Carbonic Anhydrase Inhibitor
Reversible inhibition of carbonic anhydrase in PCT & CD
39
Where does Carbonic anhydrase inhibitors act
PCT & CD
40
Main function of Carbonic Anhydrase Inhibitors
Decrease intra-ocular pressure
41
MOA of Acetazolamide
Reversible inhibition of carbonic anhydrase in PCT & CD
42
Where does Acetazolamide act on
PCT & CD
43
Acetazolamide is used to treat
Tx of open angle gluacoma
44
What diurectic is used when a patient developes toleacne to Furosemide
Acetazolamide
45
Functions of Acetazolamide
Carbonic Anhydrase Inhibitor diurectic Adjunct with patient has tolerance to loop diurectics TX open-angle gluacoma
46
What diuretic is used to treat open angle glaucoma
Acetazolamide Carbonic anhydrase inhibitor diuretic decreases intra ocular pressure

RUVM Pharmacology (5 decks)

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