Flashcards in DLA 22 + lecture 28 Deck (42)
What are the permanent residents of the connective tissue?
2. adipose tissue
3. macrophages / monocytes
4. mast cells
5. mesenchymal stem cells
What are the transient cell population of the CT?
2. plasma cells
they are the most common cell in connective tissue
synthesize fibers and ground substance
What are myofibroblasts?
presence of contractile filaments
signet ring cell
large fat inclusion
rich blood supply
What is an unilocular adipocyte?
One large fat droplet- white fat
What is an Multilocular Adipocyte?
considered brown fat
What is multilocular adipocytes characterized by?
1. many lipid droplets
2. central nucleus
3. rich in mito
4. highly vascular
5. rich in innervation
6. lipochrome pigments
7. heat production
Where is brown fat found?
body neck and abdomen of neonates
What are macrophages derived from?
they migrate to CT to differentiate
Macrophages in CT?
liver - Kupffer cells
brain - microglia
bone - osteoclasts
properties of macrophages?
1. irregular cell membrane
2. have pseudopodia
3. phagocytic; produce cytokines
4. antigen presenting cells
Explain mast cells?
they originate in the bone marrow from precursor cells
they proliferate in the lamina propria of CT
mast cells and basophils come from the same progenitor cells
small and spherical
condensed basophilic nucleus
immune cells - B and T
B cells develop into plasma cells
Explain plasma cells?
come from B lymphocytes
secretes single class of IG
red granules in the cytoplasm
condensed, bilobed nucleus
phagocytosis of antibody
kills parasitic worms
What are the classifications of connective tissue?
1. embryonic connective tissue
2. CT proper
3. specialized CT
What is the embryonic connective tissue
mesenchyme- mucous connective tissue
What are the types of CT proper?
loose connective tissue (areolar) and dense connective tissue
What are the subsections of dense connective tissue?
regular and irregular
What are the specialized connective tissue?
3. adipose tissue
5. hemopoietic tissue
6. lymphatic tissue
What are the components of connective tissue?
fibers and ground substance in the ECM
Why is CT important?
1. support (stroma- supporting structures)
3. Defense (immune function)
4. Nutrition (storage and transport)
What are the characteristics of mesenchyme?
a lot of ground substance
cells have a tapered spindle appearance
sparsely arranged reticular fibers
characteristics of mucous CT?
ground substance is a gelatinous consistency
few cells and fibers
mainly ground substance
Where is mucous CT found?
umbilical card (Wharton's jelly)
features of LCT?
large number of cells compared to fibers
rich blood supply
found below most epithelial linings
features of Dense irregular CT?
fewer cells, more fibers
no orientation of fibers
usually organ capsules, dermis, periosteum
features of dense regular CT?
specific orientation of fibers
imparts tensile strength
found in: tendons and ligaments