DOA (feel ko lang lalabas hahaha) Flashcards by lab rat

Q

Antidote used for benzodiazepine toxicity

A

Flumazenil

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Q

Benzodiazepines bind to what GABA receptor?

A

GABA A

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Q

This pyrazolopyrimidine is used for sleep disorder

A

Zaleplon

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Q

Nonselective opioid antagonist and partial agonist used for treating addiction

A

Naltrexone

naloxone is for opioid overdose

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Q

A serotonin receptor partial agonist

A

LSD

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Q

A CB1R agonist

A

cannabinoids

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Q

Drug used for treatment of alcoholism and opioid addiction

A

Naltrexone

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Q

ANTAGONIST/MIXED/STRONG/MODERATE/WEAK AGONIST?

Methadone

A

Strong

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Q

ANTAGONIST/MIXED/STRONG/MODERATE/WEAK AGONIST?

Oxycodone

A

Moderate

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Q

ANTAGONIST/MIXED/STRONG/MODERATE/WEAK AGONIST?

Nalbuphine

A

Mixed

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Q

ANTAGONIST/MIXED/STRONG/MODERATE/WEAK AGONIST?

Kratom

A

Mixed

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Q

ANTAGONIST/MIXED/STRONG/MODERATE/WEAK AGONIST?

Naloxone

A

Antagonist

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Q

ANTAGONIST/MIXED/STRONG/MODERATE/WEAK AGONIST?

Tramadol

A

Moderate

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Q

Affinity to MU/KAPPA/DELTA:

endorphins > enkephalins

A

Mu receptors

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Q

Affinity to MU/KAPPA/DELTA:

endorphins < enkephalins

A

Delta receptors

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Q

DELTA/MU/KAPPA:

endorphins = enkephalins

A

Kappa receptors

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Q

G-PROTEIN/IONOTROPIC/BIOGENIC AMINES?

Alcohol

A

Ionotropic

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Q

G-PROTEIN/IONOTROPIC/BIOGENIC AMINES?

Amphetamine

A

Biogenic Amines

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Q

G-PROTEIN/IONOTROPIC/BIOGENIC AMINES?

Cannabinoids

A

G-protein

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Q

G-PROTEIN/IONOTROPIC/BIOGENIC AMINES?

Ketamine

A

Ionotropic

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Q

G-PROTEIN/IONOTROPIC/BIOGENIC AMINES?

Mescaline

A

G-protein

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Q

G-PROTEIN/IONOTROPIC/BIOGENIC AMINES?

Psilocybin

Study These Flashcards

A

G-protein

Q

G-PROTEIN/IONOTROPIC/BIOGENIC AMINES?

Ecstasy

Study These Flashcards

A

Biogenic Amines

Q

G-PROTEIN/IONOTROPIC/BIOGENIC AMINES?

Phencyclidine

Study These Flashcards

A

Ionotropic

Acetylcholine receptor agonist | (nAChR agonist)

Nicotine

NMDA receptor antagonist

* phencyclidine * ketamine

Dopamine transporter blocker

Cocaine

reverses **serotonin** transport

Ecstasy

GABAa receptor (positive) modulator

Benzodiazepine

Blocks orexins that promote sleep onset & duration

Suvorexant

Partial serotonin agonist is used for **generalized anxiety states**

Buspirone

Activates the melatonin receptors in suprachiasmatic nuclei

Ramelteon

# Barbiturates/Benzodiazepines/Both/Neither Has high affinity to **GABA-B receptors**

Neither | **GABA-A only**

# Barbiturates/Benzodiazepines/Both/Neither Crosses the placental barrier

Both | all sedative-hypnotics cross the placental barrier

Partial agonist of nicotinic acetylcholine receptor used in **smoking cessation**

Varenicline

# Enumerate: Endogenous cannabinoids

* 2-arachidonyl **glycerol** * anandamine

# Enumerate: Exogenous cannabinoids

* THC * marijuana * nabilone * dronabinol * nabiximol

# Barbiturates/Benzodiazepines/Both/Neither Steeper dose-response curve

Barbiturates

# ANTAGONIST/MIXED/STRONG/MODERATE/WEAK AGONIST? Propoxyphene

Moderate

# Barbiturates/Benzodiazepines/Both/Neither Binds to GABA-A receptors

Both

# MU/KAPPA/DELTA/ALL: Analgesic mechanism

ALL

# MU/KAPPA/DELTA/ALL: Respiratory depressant action

Mu receptor

# MU/KAPPA/DELTA/ALL: Sedative actions

Mu receptor

# MU/KAPPA/DELTA/ALL: Psychotomimetic effects

Kappa receptor

A benzodiazepine for** delirium tremens**

Oxazepam

# NMDA ANTAGONIST for treatment of alcoholism

Acamprosate

# THIOPENTAL/SECOBARBITAL/PHENOBARBITAL For **anesthesia**

Thiopental

# THIOPENTAL/SECOBARBITAL/PHENOBARBITAL Insomnia

Secobarbital

# THIOPENTAL/SECOBARBITAL/PHENOBARBITAL Seizure disorders | requires a loading dose

Phenobarbital

Partial agonist at 5-HT

Buspirone

Excessive or unreasonable anxiety about life circumstances

generalized anxiety disorder

What type of sedation is more common with benzodiazepines that have slow elimination rates?

daytime sedation

Newer hypnotics that act like benzodiazepines (3)

* eszopiclone * zaleplon * zolpidem