Dosage exam 3 Flashcards Preview

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Flashcards in Dosage exam 3 Deck (25)
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1

Lupron

erosion-controlled system
leuprolide acetate/PLA
advanced prostate cancer

2

Zoladex

erosion-controlled system
foserelin acetate/PLGA
prostate cancer, breast cancer, endometriosis

3

Nutropin

erosion-controlled system
human growth hormone/PLGA
growth hormone deficiency

4

Gliadel Wafer

erosion-controlled system
BCNU/polyanhydride
high-grade malignant flioma

5

Oros tablet

Osmotic system
Release due to osmotic pressure difference and
diffusion

6

Benzocaine

topical effects deep tissue: local anesthetics

7

hydroquinone

topical effects deep tissue: lighten excessively pigmented skin

8

5-fluorouracil

topical effects deep tissue: skin-cancer

9

aluminum chloride

topical action on skin glands: antiperspirant

10

retinoids

topical, reset processes of epidermal proliferation and differentiation

11

petrolatum
polyethylene dissolved in mineral oil (Plastibase)

ointment, hydrocarbon base

12

polydimethylsiloxane oil

ointment, silicone base

13

ointment containing W/O emulsifiers, aqueous solution of a drug

ointment, absorption bases

14

polyethylene glycol ointment

ointment, water soluble bases

15

tragacanth

polymer for gel

16

pectin

polymer for gel

17

carrageenan

polymer for gel

18

methylcellulose

polymer for gel

19

carboxymethylcellulose

polymer for gel

20

carbopol

polymer for gel

21

ascorbate

enhancer for topical transdermal, reducing agent, disrupt disulfide bonds of proteins in keratinized cells

22

dithiothreitol

enhancer for topical transdermal, reducing agent, disrupt disulfide bonds of proteins in keratinized cells

23

azone (laurocapram)

enhancer for topical transdermal, nonpolar, oily liquid, fluidize intracellular lipid lamella region of stratum corneum
(makes paracellular space bigger)

24

diemthyl sulfoxide (DMSO)

dipolar solvent, enter aqueous region of stratum corneum, interact with lipid polar heads to expand hydrophilic region between polar heads

25

polyvinylpyrrolidone (PVP)

polymer used to make microneedles, water soluble