Dosage exam 3 Flashcards Preview

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Flashcards in Dosage exam 3 Deck (25)
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1
Q

Lupron

A

erosion-controlled system
leuprolide acetate/PLA
advanced prostate cancer

2
Q

Zoladex

A

erosion-controlled system
foserelin acetate/PLGA
prostate cancer, breast cancer, endometriosis

3
Q

Nutropin

A

erosion-controlled system
human growth hormone/PLGA
growth hormone deficiency

4
Q

Gliadel Wafer

A

erosion-controlled system
BCNU/polyanhydride
high-grade malignant flioma

5
Q

Oros tablet

A

Osmotic system
Release due to osmotic pressure difference and
diffusion

6
Q

Benzocaine

A

topical effects deep tissue: local anesthetics

7
Q

hydroquinone

A

topical effects deep tissue: lighten excessively pigmented skin

8
Q

5-fluorouracil

A

topical effects deep tissue: skin-cancer

9
Q

aluminum chloride

A

topical action on skin glands: antiperspirant

10
Q

retinoids

A

topical, reset processes of epidermal proliferation and differentiation

11
Q

petrolatum

polyethylene dissolved in mineral oil (Plastibase)

A

ointment, hydrocarbon base

12
Q

polydimethylsiloxane oil

A

ointment, silicone base

13
Q

ointment containing W/O emulsifiers, aqueous solution of a drug

A

ointment, absorption bases

14
Q

polyethylene glycol ointment

A

ointment, water soluble bases

15
Q

tragacanth

A

polymer for gel

16
Q

pectin

A

polymer for gel

17
Q

carrageenan

A

polymer for gel

18
Q

methylcellulose

A

polymer for gel

19
Q

carboxymethylcellulose

A

polymer for gel

20
Q

carbopol

A

polymer for gel

21
Q

ascorbate

A

enhancer for topical transdermal, reducing agent, disrupt disulfide bonds of proteins in keratinized cells

22
Q

dithiothreitol

A

enhancer for topical transdermal, reducing agent, disrupt disulfide bonds of proteins in keratinized cells

23
Q

azone (laurocapram)

A

enhancer for topical transdermal, nonpolar, oily liquid, fluidize intracellular lipid lamella region of stratum corneum
(makes paracellular space bigger)

24
Q

diemthyl sulfoxide (DMSO)

A

dipolar solvent, enter aqueous region of stratum corneum, interact with lipid polar heads to expand hydrophilic region between polar heads

25
Q

polyvinylpyrrolidone (PVP)

A

polymer used to make microneedles, water soluble