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Flashcards in Renal drugs Deck (47)
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1

Acetazolamide (Diamox)

Proximal Tubule: Carbonic Anhydrase Inhibitor

2

Furosemide (Laxis)

Loop diuretic "high ceiling" (Loop of hence-thick ascending limb)

3

Bumeanide (Bumex)

Loop diuretic "high ceiling" (Loop of hence-thick ascending limb)

4

Ethacrynic Acid (Edacrin)

Loop diuretic "high ceiling" (Loop of hence-thick ascending limb)

5

Acetazolamid (Diamox)
Actions:

-decrease NaHCO3 reabsorption
-decrease H2O reabsorption
-metabolic acidosis

6

Acetazolamid (Diamox)
Clinical uses:

-acute mountain sickness
-metabolic alkalosis
-glaucoma
-urinary alkalizations

7

Acetazolamid (Diamox)
Toxicities:

-hyperchloremic metabolic acidosis
-renal stones
-renal potassium wasting
-drowsiness/paresthesia

8

Acetazolamid (Diamox)
Contraindications:

-hepatic cirrhosis
-sulfa allergies

9

Loop Diuretics Actions:

-inhibit the Na+/K+/2Cl- cotransporter in the thick ascending limb
-reduce NaCl, K+ and divalent cations (Ca2+ and Mg2+) reabsorption
-increase renal blood flow
-rapid response after I.V. administration
-duration of action dependent upon renal function

10

Loop Diuretics Clinical Uses:

-edematous conditions
-acute pulmonary edema
-acute hypercalcemia
-hyperkalemia
-acute renal failure
-anion overdose

11

Loop Diuretics toxicities

-dehydration
-hypokalemic metabolic alkalosis
-ototoxicity
-hyperuricemia
-hypomagnesemia

12

Loop diuretics contraindications:

sulfa allergy

13

Thiazides act

distal convoluted tubule: Na+ Cl- symport inhibitors

14

chlorthalidone (Hygroton)

thiazide like

15

indapamide (Lozol)

thiazide like

16

metolazone (Diulo, Zaroxolyn)

thiazide like

17

thiazide actions:

-inhibit the NaCl
-reabsorption in the distal convoluted tubule
-enhance Ca2+ reabsorption

18

thiazide clinical uses:

-hypertension
-congestive heart failure
-nephrolithiasis due to idiopathic hypercalciuria
-nephrogenic diabetes inspidus

19

thiazide toxicities:

-hypokalemic metabolic alkalosis and hyperuricemia
-impaired carbohydrate
-hyperlipidemia
-hyponatremia

20

thiazide contraindications:

sulfa allergies

21

Amiloride (Midamor) act

diuretics that act in the collecting tubule: Na+ channel inhibitors

22

Amiloride (Midamor) actions:

-inhibit the Na+ channels in the apical membrane of the collecting tubule
-reduce Na+ entry into these cells also reduces K+ excertion (K+ sparing)

23

Amiloride (Midamor) clinical uses:

-adjunctive treatment with thiazide or loop diuretic in CHF or hypertension

24

Amiloride (Midamor) toxicities:

-hyperkalemia
-hperchloremic metabolic acidosis

25

Amiloride (Midamor) contraindications:

-K+ supplements
-ACE inhibitors (cause retention of K+)

26

Triamterene (Dyrenium) actions:

-inhibit the Na+ channels in the apical membrane of the collecting tubule
-reduce Na+ entry into these cells also reduces K+ excretion (K+sparing)

27

Triamterene (Dyrenium) clinical uses:

-edema associated with CHF, nematic cirrhosis, nephrotic syndrome, or hyperaldosteronism

28

Triamterene (Dyrenium) toxicities:

-hyperkalemia
-hyperchloremic metabolic acidosis

29

Triamterene (Dyrenium) contraindications:

-kidney stones
-K+ supplements, ACE inhibitors

30

Spironlactone (Aldactone) actions:

-block actions of aldosteron
-inhibition of 5alpha-reductace