Dosing exam 3

Question 1

donepezil

Answer 1

5 mg PO once daily at bedtime
increase to 10 mg after 4-6 weeks

Question 2

donepezil and galantamine side effects

Answer 2

GI bleed, N/V/D, bradycardia, insomnia, weight loss

Question 3

donepezil and galantaminer are ____ substrates

Answer 3

CYP2D6 and 3A4

Question 4

galantamine dose

Answer 4

4 mg PO BID for 4 weeks with breakfast and dinner

Question 5

doses of galantamine not recomended in hepatic impairment

Answer 5

16 mg /day

Question 6

rivastigmine dose

Answer 6

1.5 mg BID and titrate up
take with meals to minimize GI

Question 7

rivastigmine patch tips

Answer 7

toxicity if we dont remove patch

Question 8

rivastigmine side effects

Answer 8

GI Bleed, weight loss, esophageal rupture

Question 9

memantine dose adjustment

Answer 9

CrCL <30 = 5 mg x 1 week then target BID

Question 10

memantine side effects

Answer 10

caution in seizure disorder
hallucinations, insomnia, conf

Question 11

memantine and donepezil dosing

Answer 11

donepezil 10mg: Namzaric 7/10, increase by 7 mg
memantine 10mg or 28mg: Namzaric 28/10

Question 12

warning with memantine and donepezil combo

Answer 12

bradycardia and heart block
GI ulcer, N/V, bladder issues