dpamine

Question 1

Why is Dopamine not used to treat Parkinson’s Disease directly?

Answer 1

It cannot cross the Blood-Brain Barrier (BBB).

Question 2

Which enzyme converts L-Dopa to Dopamine?

Answer 2

DOPA Decarboxylase (Aromatic L-amino acid decarboxylase).

Question 3

What is the pharmacological effect of low-dose (1-2 mcg) Dopamine?

Answer 3

Renal and mesenteric vasodilation via D1 receptors.

Question 4

At what dose range does Dopamine primarily act on Beta-1 receptors?

Answer 4

2 to 10 µg/kg/min.

Question 5

What is the clinical result of high-dose (>10 mcg) Dopamine infusion?

Answer 5

Systemic vasoconstriction and increased BP via Alpha-1 receptors.

Question 6

What is the drug of choice to treat skin necrosis caused by Dopamine extravasation?

Answer 6

Phentolamine (Alpha blocker).

Question 7

What is the major metabolic end-product of Dopamine excreted in urine?

Answer 7

Homovanillic Acid (HVA).

Question 8

Which selective D1 agonist is used in Hypertensive Emergencies?

Answer 8

Fenoldopam.

Question 9

How does Dopamine influence Prolactin secretion?

Answer 9

It inhibits Prolactin release (acting as Prolactin Inhibiting Factor).

Question 10

Why is Dopamine preferred over Norepinephrine in early cardiogenic shock?

Answer 10

It increases Cardiac Output while preserving Renal Blood Flow at lower doses.