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Pharmocokinetics > Drug Clearance > Flashcards

Drug Clearance Flashcards

1
Q

Define drug clearance

A

Volume of plasma cleared entirely of drug per unit time

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2
Q

Units of drug clearance

A

mL /min or L /hr

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3
Q

Drug clearance is a constant proportionally between?

A

Rate of elimination and the plasma concentration

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4
Q

If 25% of plasma flowing through the kidney (approx. 1L /min ) is cleared of drug. What is the clearance?

A

250 mL/ min

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5
Q

Elimination rate =
EQUATION

A

Clearance x plasma concentration

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6
Q

Clearance is ?/?
EQUATION

A

Volume / time

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7
Q

Plasma concentration is ?
EQUATION

A

Mass / volume

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8
Q

Elimination= ?/?
EQUATION

A

Mass / time

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9
Q

Equation: clearance total =

A

CL hepatic + CL renal + CL other

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10
Q

If 1/3 of the drug is eliminated through the kidneys then you can describe it as having a significant renal elimination route. Why is that Important?

A

need to know how a drug is cleared, so you know it is set to be given through that route

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11
Q

Equation: Amount in body mg =

A

Volume, L x concentration, mg/L

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12
Q

Half life equation

A

= ln (2) V / CL

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13
Q

Initial concentration mg/L =
EQUATION

A

Dose mg/ volume L

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14
Q

Concentration at time t=
EQUATION

A

Initial concentration x e^ -CL/V ^t

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15
Q

Calculation for constant rate infusion at steady rate, concentration =

A

Infusion rate / CL

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16
Q

Clearance is only constant it?

A

The elimination process isn’t saturated

17
Q

Calculation for clearance in kinetic graph ( rate of elimination plotted against drug concentration in plasma)

A

Clearance= rate of elimination / concentration

18
Q

In first order kinetics describe graph for clearance

A

Constant line up
Rate of elimination is proportional to drug concentration in plasma
Higher drug concentration, higher the elimination rate

19
Q

In zero order kinetics describe graph for clearance

A

Rate of elimination reaches a plateau as drug concentration in plasma increases
Zero order elimination rate is independent of concentration

20
Q

Alcohol is an example that shows what order of kinetics for clearance

A

Zero

Pharmocokinetics (22 decks)

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