renal disease & drug handling

Question 1

rate of excretion varies dependent upon?

Answer 1

drug concentration

Question 2

clearance is defined as:

Answer 2

the volume of plasma cleared entirely of drug per unit time (ml/min)

Question 3

if plasma flow to the kidney is 600ml/min, and 50% of the drug is removed, then clearance is:

Answer 3

600 x 0.5= 300ml/min