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Natsumi - NPLEX 2 > Drug Interactions > Flashcards

Drug Interactions Flashcards

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1
Q

Which 2 antibiotics induce HYPOglycemia?

A
  1. Ciprofloxacin

2. Sulfamethoxazole

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2
Q

Which 2 anti-hypertensives induce HYPOglycemia?

A
  1. ACE inhibitor (Lisinopril)

2. Beta blockers (atenolol, propranolol, carvedilol)

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3
Q

Which 2 diabetes medications induce HYPOglycemia?

A
  1. Insulin

2. Glyburide

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4
Q

Which SSRI induces HYPOglycemia?

A

Fluoxetine

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5
Q

Which 2 antiretrovirals induce HYPERglycemia?

A
  1. Zidovudine

2. Adevofir

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6
Q

T/F: Prednisone is the only glucocorticoid that induces HYPERglycemia

A

FALSE! All of the glucocorticoids induce hyperglycemia

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7
Q

Which 3 types of anti-hypertensive medications induce HYPERglycemia?

A
  1. Ca channel blocker:Amlopidine
  2. Beta blockers: Atenolol and propranolol
  3. Diuretics: Furosemide (Loop) and Hydrochlorothiazide (Thiazide)
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8
Q

Which second generation (atypical) antipsychotic medication induces HYPERglycemia?

A

Risperidone

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9
Q

Which 3 lipid-lowering agent induce HYPERglycemia?

A
  1. Fish-oil (>3g daily)
  2. Atorvastatin
  3. Niacin (>2g daily)
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10
Q

Which 2 antacids deplete K+?

A
  1. Sodium bicarbonate

2. Calcium bicarbonate

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11
Q

Which 2 anti-inflammatory medications deplete K+?

A
  1. Corticosteroids

2. Aspirin

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12
Q

Which 2 diuretics deplete K+?

A
  1. Furosemide (loop)

2. Hydrochlorothiazide (thiazides)

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13
Q

Which gout medication depletes K+?

A

Colchicine

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14
Q

Which laxative medication depletes K+?

A

Bisacodyl

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15
Q

Which ACE inhibitor medication increases K+?

A

Lisinopril

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16
Q

Which angiotensin-receptor blocker medication increases K+?

A

Valsartan

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17
Q

Which 3 beta-blocker medications increase K+?

A
  1. Atenolol
  2. Propranolol
  3. Carvedilol
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18
Q

Which 2 anti-fungal medications increase K+?

A
  1. Fluconazole

2. Metronidazole

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19
Q

Which diuretic medication increases K+?

A

Spironolactone

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20
Q

Which antibiotic medication increases K+?

A

Penicillin VK

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21
Q

Which 2 anti-inflammatory medications increase K+?

A
  1. Ibuprofen

2. Naproxen

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22
Q

What are 3 other medications increase K+?

A
  1. Heparin
  2. Cyclosporine
  3. Digoxin
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23
Q

Which 3 drugs induce p-glycoprotein?

A
  1. Carbamazepine
  2. Phenytoin
  3. Phenobarbital
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24
Q

Which 4 drugs inhibit P-glycoprotein?

A
  1. Amiodarone
  2. Carvedilol
  3. Azithromycin
  4. Cyclosporine
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25
Aspirin + Ibuprofen =
Decreased effect
26
ACE inhibitor (Lisinopril) + NSAIDS =
1. Reduced effect of Lisinopril | 2. Acute renal failure
27
Levodopa + Risperidone =
Decreased effect
28
Warfarin + Vitamin K =
Reduced effect of warfarin
29
Beta blockers + Beta agonist (albuterol) =
Blocks effect, precipitate bronchospasm
30
Anticholinergic drugs + acetylcholinesterase inhibitors =
Blocks effect
31
Carbamazepine + OCPs =
Pregnancy
32
Carbamazepine + Warfarin =
Increased risk of coagulation
33
Carbamazepine + Cyclosporine =
Increased dose
34
NSAIDS + SSRI (Fluoxetine) or Warfarin =
Increased risk of bleeding
35
NSAIDS + Glucocorticoids (All) =
Increased risk of gastric bleeding
36
ACE inhibitors (Lisinopril) + Spironolactone =
Hyperkalemia (arrhythmia) | Renal failure
37
SSRIs (Fluoxetine) + Triptans (sumatriptan) =
Serotonin syndrome
38
SSRIs (Fluoxetine) + 5HTP, tryptophan, melatonin =
Serotonin syndrome
39
SSRIs (Fluoxetine) + TCA (amitryptaline) =
Serotonin syndrome
40
SSRIs (Fluoxetine) + MAO inhibitors (Phenelzine) =
Serotonin syndrome
41
Trazodone + Buspirone =
Serotonin syndrome
42
MAO inhibitors + amphetamines =
Hypertensive crisis (Sometimes fatal)
43
MAO inhibitors + Sympatomimetics =
Hypertensive crisis (Sometimes fatal)
44
MAO inhibitors + Bupropione =
Hypertensive crisis (Sometimes fatal)
45
MAO inhibitors + Serotonergic agents (Trazodone, Fluoxetine, Sumatriptan) =
Hypertensive crisis (Sometimes fatal)
46
Beta blockers (all) + Calcium channel blockers (Amlodipine) =
Serious bradycardia
47
What are 2 oculotoxic responses to Isotretinoin?
1. Dry eyes | 2. Sudden decrease in night vision
48
What is the oculotoxic response to antihistamine use?
Angle-closure glaucoma | s/sx: HA, eye pain, N&V, blurred vision, halo vision around lights
49
What is the oculotoxic response to hydroxychloroquine?
Retinal toxicity leading to permanent vision loss
50
What is the oculotoxic response to prednisone?
Cause an elevation in eye pressure, which is a major risk factor for developing glaucoma and is also associated with cataracts
51
What are 3 oculotoxic responses to Sildenafil?
1. Blurred vision 2. Sensitivity to light 3. Seeing a temporary blue tinge to objects
52
What is the oculotoxic response to Tamsulosin?
Builds up in the iris and can prevent the pupil from dilating
53
What are 2 oculotoxic responses to Amiodarone?
1. Optic neuropathy/neuritis | 2. Corneal micro-deposits
54
What is the oculotoxic response to Tamoxifen?
Crystalline retinopathy
55
Penicillin & Amoxicillin + Methotrexate =
Increase in SEs of methotrexate (N&V, mouth ulcers, low blood cell #, weakness)
56
Ciprofloxacin + Theophylline =
Increase in SEs of theophylline (N&V, diarrhea, HA, insomnia, seizures, heart palpitations)
57
Ciprofloxacin + Prednisone (and all other corticosteroids) =
Can increase risk of tendinitis and tendon rupture
58
Ciprofloxacin + Warfarin =
Bleeding more easily
59
Ciprofloxacin + Bupropione =
Can increase risk of seizure
60
Ciprofloxacin + Amiodarone =
Can increase the risk of an irregular heart rhythm
61
Ciprofloxacin + Antacids, zinc supplements, or high concentrations of multi-vitamins =
Reduces absorption and block effect of antibiotic
62
Doxycycline + Vitamin A or Fish oil =
May increase risk of increased pressure in the brain
63
Doxycycline + Isotretinoin =
May increase risk of increased pressure in the brain
64
Doxycycline + Methotrexate =
Increase in SEs of methotrexate (N&V, mouth ulcers, low blood cell #, weakness)
65
Azythromycin + Amiodarone =
Can increase risk of an irregular heart rhythm that is potentially life-threatening
66
SMZ + Warfarin =
May increase risk of bleeding
67
SMZ + Methotrexate =
Increase in SEs of methotrexate (N&V, mouth ulcers, low blood cell #, weakness)
68
SMZ + Cyclosporine =
Can add to the risk of organ rejection
69
Trimethoprim + Methotrexate =
Can cause suppression of bone marrow activity

Natsumi - NPLEX 2 (37 decks)

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