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Flashcards in Drug reactions Deck (44):
1

Adrenocortical insufficiency

HPA suppression secondary to glucocorticoid withdrawal

2

Hot flashes

Tamoxifene, Clomiphene (antagonist of estrogen receptor at hypothalamus)

3

Hyperglycemia

Tacrolimus
Protease inhibitors (-navir)
Niacin
HCTZ
Corticosteroids

4

Hypothyroidism

Lithium (LMNOP)
Amiodarone (Check LFTs, TFTs, PFTs)
Sulfonamides

5

Gynecomastia

Cimetidine
Spironolactone
Estrogen
Digoxin
Chronic alcohol
Ketoconazole

6

Acute cholestatic hepatitis, jaundice

Erythromycin

7

Diarrhea

Metformin
Erythromycin
Colchicine
Orlistat (inhibits gastric and pancreatic lipase)
Acarbose (inhibits brush border alpha glucosidases)

8

Focal to massive hepatic necrosis

Halothane
Valproic acid
Acetaminophen
Amanita phalloides

9

Hepatitis

Rifampin
Isoniazid
Pyrazinamide
Statins

10

Pancreatitis

Didanosine (NRTI)
Corticosteroids
Alcohol
Valproic acid
Azathioprine
Diuretics (Furosemide, HCTZ)

11

Pseudomembranous colitis

Clindamycin
Ampicillin
Cephalosporins

12

Agranulocytosis (Gangs CCCrush Myeloblasts and Promyelocytes)

Ganciclovir
Clozapine
Carbamazepine
Colchicine
Methimazole
Propylthiouracil
Dapsone

13

Aplastic anemia (Can't Make New Blood Cells Properly)

Carbamazepine
Methimazole
NSAIDs
Benzene
Chloramphenicol
Propylthiouracil

14

Direct Coombs positive hemolytic anemia

Methyldopa
Penicillin

15

Gray baby syndrome

Chloramphenicol (also causes aplastic anemia)

16

Hemolysis in G6PD deficiency

Isoniazid
Sulfonamides
Dapsone
Primaquine
Aspirin
Iburprofen
Nitrofurantoin
Fava beans

17

Megaloblastic anemia

Phenytoin
Methotrexate
Sulfa drugs

18

Thrombocytopenia

Heparin
Cimetidine

19

Thrombotic complications

OCPs
Hormone replacement therapy

20

Fat redistribution

Protease inhibitors
Glucocorticoids

21

Gingival hyperplasia

Phenytoin
Calcium channel blockers
Cyclosporine

22

Hyperuricemia

Pyrazinamide
Thiazides
Furosemide
Niacin
Cyclosporine

23

Myopathy

Fibrates
Niacin
Colchicine
Hydroxychloroquine
Interferon alpha
Penicillamine
Statins
Glucocorticoids

24

Osteoporosis

Corticosteroids
Heparin
Avoid PPIs and H2 blockers

25

Photosensitivity

Sulfonamides
Amiodarone
Tetracycline
5-FU

26

Rash (Steven's Johnson) (Steven Johnson has epileptic allergy to sulfa drugs and penicillin)

Anti-epileptic
Allopurinol
Sulfa drugs
Penicillin

27

SLE-like syndrome

Sulfa drugs
Hydralazine
Isoniazid
Procainamide
Phenytoin
Etanercept

28

Teeth discoloration

Tetracycline

29

Tendonitis, Tendon rupture, cartilage damage

Fluoroquinolones (Ciprofloxacin)

30

Cinchonism

Quinidine, Quinine

31

Parkinson-like syndrome

Antipsychotics, Reserpine, Metoclopramide

32

Seizures

Isoniazid
Bupropion
Imipenem
Enflurane

33

Tardive dyskinesia

Antipsychotics
Metoclopramide

34

Diabetes insipidus

Lithium
Demeclocycline (ADH antagonist)

35

Fanconi syndrome

Expired tetracycline

36

Hemorrhagic cystitis

Cyclophosphamide, ifosfamide (prevent with mesna)

37

Interstitial nephritis

Methicillin
NSAIDs
Furosemide

38

SIADH

Carbamazepine
Cyclophosphamide
SSRIs

39

Dry cough

ACE inhibitors (from increased bradykinin)

40

Pulmonary fibrosis

Bleomycin
Busulfan
Amiodarone
Methotrexate

41

Antimuscarinic

Atropine
TCAs
H1 blockers
Anti-psychotics

42

Disulfiram like reaction

Metronidazole
Cephalosporins
Griseofulvins
Procarbazine
1st generation sulfonylureas

43

Nephrotoxicity, Otoxicity

Aminoglycosides
Vancomycin
Loop diuretics
Cisplatin (give with Amifostine)

44

What are sulfa drugs?

Probenecid
Furosemide
Acetazolamide
Celecoxib
Thiazides
Sulfonamide Abx
Sulfasalazine
Sulfonylureas