Lipid Lowering Drugs Flashcards Preview

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Flashcards in Lipid Lowering Drugs Deck (17):
1

Mechanism of Statins

Inhibits conversion of HMG CoA to mevalonate by inhibiting HMG CoA reductase --> decreased cholesterol production --> causes up regulation of LDL receptors on hepatocytes

2

Statin effect on LDL, HDL, Triglycerides

LOWERS LDL, increases HDL, decreases TGs

3

S/E of Statins

Myopathy (Esp used with Niacin and Fibrates)
Hepatotoxicity

4

Bile acid resins

Cholestyramine
Colestipol
Colesevelam

5

Bile acid resin mechanism

Prevent intestinal reabsorption of bile acids --> liver must use cholesterol to make more

6

Bile acid resin's effect on LDL, HDL, TGs

Decrease LDL, slightly increase HDL, slightly increase TGs

7

S/E of Bile acid resins (cholestyramine)

GI upset
Decreased absorption of other drugs and fat soluble vitamins
Increased risk of gallstones

8

Ezetimibe mechanism

Prevent cholesterol absorption at small intestine brush border

9

Ezetimibe S/E

Increase LFTs (rare)
Diarrhea

10

Ezetimibe effect on LDL, HDL, TGs

Decrease LDL
No effect on HDL or TGs

11

Fibrates

Gemfibrozil
Clofibrate
Bezafibrate
Fenofibrate

12

Fibrates mechanism

Upregulate LPL --> increased TG clearance
Activates PPAR-alpha to induce HDL synthesis
Suppression of cholesterol 7 alpha hydroxylase

13

Fibrates effect on LDL, HDL, TGs

Decrease LDL, increase HDL, DECREASE TGs

14

Fibrates S/E

Myopathy (increased risk with statins)
Cholesterol gallstones

15

Niacin mechanism

Inhibits lipolysis in adipose tissue
Reduces hepatic VLDL synthesis

16

Niacin effect on LDL, HDL, TGs

Decrease LDL, INCREASE HDL, decrease TGs

17

S/E of Niacin

Hyperglycermia
Hyperuricemia
Red, flushed face (decreased by NSAIDs)