DRUG REACTIONS AND ANTIDOTES Flashcards Preview

PHARM SHELF AND BOARDS > DRUG REACTIONS AND ANTIDOTES > Flashcards

Flashcards in DRUG REACTIONS AND ANTIDOTES Deck (65):
1

2 drugs that can cause direct Coomb's positive hemolytic anemia

methyldopa and penicillin

2

What is the antidote for beta blocker overdose?

glucagon

2

What is the antidote for digitalis (4)?

(KLAM) normalize K, lidocaine, Anti-dig Fab, Mg

3

What is the antidote for tPA, streptokinase, and urokinase?

aminocaproic acid

3

2 drugs that cause osteoporosis

corticosteroids and heparin

4

Which 4 drugs have anti-muscarinic side effects?

Atropine, TCA's, H1 blockers, and neuroleptics

5

What is the antidote for theophylline?

Beta blocker

7

What is the antidote for salicylate toxicity?

NaHCO3 to alkalinze the urine

7

3 drugs causing photosensitivity

sulfonamides, amiodarone, and tetracyclines

8

What is the antidote for benzodiazepine toxicity?

Flumazenil

8

TB drug that causes hepatitis

isoniazid

8

6 drugs causing gynecomastia

Cimetidine, Spironolactone, Digitalis, Estrogen, Chronic Alcohol abuse, and Ketoconazole

9

What is the antidote for copper, arsenic and gold poisoning?

penicillamine

10

4 drugs that precipitate gout

Loop diuretics, Thiazide diuretics, Niacin, and Cyclosporine

10

8 drugs that cause myopathies

Fibrates, Statins, Niacin, Colchicine, Hydroxychloroquine, IFN alpha, Penicillamine, and Glucocorticoids

11

2 drugs that can cause nephrogenic diabetes insipidus

lithium and demeclocycline (Recall: demeclocycline is USED to Tx the opposite condition, SIADH)

12

What is the antidote for iron toxicity?

Defuroxamine, Deferasirox

12

7 drugs causing hemolysis in G6PD patients

Isoniazid, Dapsone, Sulfonamides, Primaquine, Aspirin, Ibuprofen, and Nitrofurantoin

13

What is the antidote for acetaminophen toxicity?

N-acetylcysteine

14

Drug that causes Gray Baby Syndrome

Chloramphenicol

14

Drug that can cause acute cholestatic hepatitis and jaundice

erythromycin

15

2 classes of drugs that cause Torsades

Class III (sotalol) and Class Ia (quinidine)

16

3 drugs causing a Parkinson-like syndrome

Antipsychotics, reserpine, and metoclopromide

18

What is the treatment for methemoglobinemia?

Methylene blue and vitamin C

19

What is the antidote for opioid toxicity?

naloxone (IV), naltrexone (PO)

20

3 drugs causing pulmonary fibrosis

Bleomycin, Amiodarone, Busulfan

21

8 drugs that cause Stevens Johnson Syndrome

Penicillin, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital (LOTS OF NEURO DRUGS!)

21

4 drugs that cause nephrotoxicity and ototoxicity

Aminoglycosides, Cisplatin, Loop diuretics, and Vancomycin

22

Drug most implicated in pseudomembranous colitis

clindamycin (ampicillin as well)

24

What is the antidote for lead toxicity (4)?

CaEDTA, dimercaprol, succimer, penicillamine

25

5 drugs causing hyperglycemia

Niacin, Tacrolimus, protease inhibitors, HCTZ, corticosteroids

26

2 drugs that can cause SIADH

Carbamazepine and Cyclophosphamide

27

What type of drug can cause Tardive Dyskinesia?

antipsychotics and (I think) metoclopromide

28

What is the antidote for mercury, aresenic and gold poisoning?

Dimercaprol, succimer

29

2 drugs that cause hemorrhagic cystitis. How to prevent?

Cyclophosphamide and ifosfamide; co-administer mesna

30

6 drugs that may cause seizures

isoniazid, bupropion, imipenem/cilastatin, tramadol, enflurane, metoclopromide

31

2 drugs that can cause cinchonism

Quinidine and Quinine

32

2 drugs that cause gingival hyperplasia

phenytoin and verapamil

33

2 drugs causing hot flashes

clomiphene and tamoxifen

35

2 drugs that cause dilated cardiomyopathy

doxorubicin, daunorubicin

36

2 drugs that cause fat redistribution

protease inhibitors and glucocorticoids

37

Drugs that cause tooth abnormalities in kids

tetracyclines

38

3 drugs causing megaloblastic anemia

phenytoin, methotrexate, sulfa drugs (i.e. TMP-SMX)

39

3 drugs that cause coronary vasospasm

Sumatriptan, Cocaine, Ergot alkaloids

40

Drug causing adrenocortical insufficiency

glucocorticoid withdrawal

42

What is the treatment for cyanide poisoning?

Nitrite and Thiosulfate with hydroxycobalamin

43

What is the antidote for amphetamines?

They are basic so you give NH4Cl to acidify the urine (ammonium chloride)

44

5 drugs that cause aplastic anemia

Chloramphenicol, benzene, NSAIDs, propylthiouracil and methimazole

45

Drugs that cause tendonitis, tendon rupture, and cartilage damage

fluoroquinolones

46

Which 4 drugs have disulfiram like reaction

Metronidazole, some cephalosporins, procarbazine, and 1st generation sulfonylureas

48

What is the antidote for carbon monoxide poisoning?

100% O2 or hyperbaric O2

50

What is the antidote for heparin toxicity?

Protamine sulfate

51

What is the antidote for TCA's?

NaHCO3 to alkalinize the plasma

53

3 drugs causing hypothyroidism

lithium, amiodarone, sulfonamides

54

Drugs that cause a cough

ACE inhibitors

55

6 drugs that cause agranulocytosis

Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone

56

What is the antidote for acetylcholinesterase inhibitors and organophosphates?

atropine and pralidoxime

57

The 4 drugs causing lupus like syndrome

Hydralazine, Phenytoin, Procainamide, Isoniazid

58

What is the antidote for warfarin toxicity?

Fresh Frozen Plasma acutely, Vitamin K for longterm

59

4 drugs that cause cutaneous flushing

Vancomycin (red man syndrome), Adenosine, CCB's, Niacin

60

What is the antidote for antimuscarinic and anticholinergic agents?

physostigmine

62

4 drugs that can cause focal to massive hepatic necrosis

Halothane, Amanita phalloides, Valproic acid, and Acetaminophen

63

What is the antidote for methanol and ethylene glycol poisoning?

Fomepizole > ethanol, dialysis

64

Drugs notorious for thrombotic complications

OCP's

65

3 drugs causing interstitial nephritis

Methicillin, NSAIDs, and furosemide