2 drugs that can cause direct Coomb's positive hemolytic anemia
methyldopa and penicillin
What is the antidote for beta blocker overdose?
What is the antidote for digitalis (4)?
(KLAM) normalize K, lidocaine, Anti-dig Fab, Mg
What is the antidote for tPA, streptokinase, and urokinase?
2 drugs that cause osteoporosis
corticosteroids and heparin
Which 4 drugs have anti-muscarinic side effects?
Atropine, TCA's, H1 blockers, and neuroleptics
What is the antidote for theophylline?
What is the antidote for salicylate toxicity?
NaHCO3 to alkalinze the urine
3 drugs causing photosensitivity
sulfonamides, amiodarone, and tetracyclines
What is the antidote for benzodiazepine toxicity?
TB drug that causes hepatitis
6 drugs causing gynecomastia
Cimetidine, Spironolactone, Digitalis, Estrogen, Chronic Alcohol abuse, and Ketoconazole
What is the antidote for copper, arsenic and gold poisoning?
4 drugs that precipitate gout
Loop diuretics, Thiazide diuretics, Niacin, and Cyclosporine
8 drugs that cause myopathies
Fibrates, Statins, Niacin, Colchicine, Hydroxychloroquine, IFN alpha, Penicillamine, and Glucocorticoids
2 drugs that can cause nephrogenic diabetes insipidus
lithium and demeclocycline (Recall: demeclocycline is USED to Tx the opposite condition, SIADH)
What is the antidote for iron toxicity?
7 drugs causing hemolysis in G6PD patients
Isoniazid, Dapsone, Sulfonamides, Primaquine, Aspirin, Ibuprofen, and Nitrofurantoin
What is the antidote for acetaminophen toxicity?
Drug that causes Gray Baby Syndrome
Drug that can cause acute cholestatic hepatitis and jaundice
2 classes of drugs that cause Torsades
Class III (sotalol) and Class Ia (quinidine)
3 drugs causing a Parkinson-like syndrome
Antipsychotics, reserpine, and metoclopromide
What is the treatment for methemoglobinemia?
Methylene blue and vitamin C
What is the antidote for opioid toxicity?
naloxone (IV), naltrexone (PO)
3 drugs causing pulmonary fibrosis
Bleomycin, Amiodarone, Busulfan
8 drugs that cause Stevens Johnson Syndrome
Penicillin, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital (LOTS OF NEURO DRUGS!)
4 drugs that cause nephrotoxicity and ototoxicity
Aminoglycosides, Cisplatin, Loop diuretics, and Vancomycin
Drug most implicated in pseudomembranous colitis
clindamycin (ampicillin as well)
What is the antidote for lead toxicity (4)?
CaEDTA, dimercaprol, succimer, penicillamine
5 drugs causing hyperglycemia
Niacin, Tacrolimus, protease inhibitors, HCTZ, corticosteroids
2 drugs that can cause SIADH
Carbamazepine and Cyclophosphamide
What type of drug can cause Tardive Dyskinesia?
antipsychotics and (I think) metoclopromide
What is the antidote for mercury, aresenic and gold poisoning?
2 drugs that cause hemorrhagic cystitis. How to prevent?
Cyclophosphamide and ifosfamide; co-administer mesna
6 drugs that may cause seizures
isoniazid, bupropion, imipenem/cilastatin, tramadol, enflurane, metoclopromide
2 drugs that can cause cinchonism
Quinidine and Quinine
2 drugs that cause gingival hyperplasia
phenytoin and verapamil
2 drugs causing hot flashes
clomiphene and tamoxifen
2 drugs that cause dilated cardiomyopathy
2 drugs that cause fat redistribution
protease inhibitors and glucocorticoids
Drugs that cause tooth abnormalities in kids
3 drugs causing megaloblastic anemia
phenytoin, methotrexate, sulfa drugs (i.e. TMP-SMX)
3 drugs that cause coronary vasospasm
Sumatriptan, Cocaine, Ergot alkaloids
Drug causing adrenocortical insufficiency
What is the treatment for cyanide poisoning?
Nitrite and Thiosulfate with hydroxycobalamin
What is the antidote for amphetamines?
They are basic so you give NH4Cl to acidify the urine (ammonium chloride)
5 drugs that cause aplastic anemia
Chloramphenicol, benzene, NSAIDs, propylthiouracil and methimazole
Drugs that cause tendonitis, tendon rupture, and cartilage damage
Which 4 drugs have disulfiram like reaction
Metronidazole, some cephalosporins, procarbazine, and 1st generation sulfonylureas
What is the antidote for carbon monoxide poisoning?
100% O2 or hyperbaric O2
What is the antidote for heparin toxicity?
What is the antidote for TCA's?
NaHCO3 to alkalinize the plasma
3 drugs causing hypothyroidism
lithium, amiodarone, sulfonamides
Drugs that cause a cough
6 drugs that cause agranulocytosis
Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone
What is the antidote for acetylcholinesterase inhibitors and organophosphates?
atropine and pralidoxime
The 4 drugs causing lupus like syndrome
Hydralazine, Phenytoin, Procainamide, Isoniazid
What is the antidote for warfarin toxicity?
Fresh Frozen Plasma acutely, Vitamin K for longterm
4 drugs that cause cutaneous flushing
Vancomycin (red man syndrome), Adenosine, CCB's, Niacin
What is the antidote for antimuscarinic and anticholinergic agents?
4 drugs that can cause focal to massive hepatic necrosis
Halothane, Amanita phalloides, Valproic acid, and Acetaminophen
What is the antidote for methanol and ethylene glycol poisoning?
Fomepizole > ethanol, dialysis
Drugs notorious for thrombotic complications
3 drugs causing interstitial nephritis
Methicillin, NSAIDs, and furosemide