IMMUNO AND ENVIRONMENTAL TOXINS Flashcards Preview

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Flashcards in IMMUNO AND ENVIRONMENTAL TOXINS Deck (21):
1

Which drug increases the toxic effects of azathioprine and 6-mercaptopurine?

Allpurinol, both are metabolized by xanthine oxidase

2

What is the MOA of sirolimus?

inhibits mTOR which inhibits T cell proliferation in response to IL-2

2

What would arsenic cause in the liver?

Angiosarcoma

3

Which AE does cyclosporine have that tacrolimus does not have?

Gingival hyperplasia and Hirsutism

4

What drug binds to cyclophilin forming a complex that then inhibits calcineurin and blocks differentiation and activation of T cells by preventing IL-2 and IL-2R production?

Cyclosporine

5

What can naphthalene cause?

Transitional cell carcinoma

6

Which immunosuppressive drug inhibits mTOR?

Sirolimus (rapamycin)

7

What is the difference between tacrolimus and cyclosporine?

Both ultimately block calcineurin; but cyclosporin does so by forming a complex with cyclophilin and tacrolimus does so by forming a complex with FK-binding protein

8

What effect might aflatoxins have on the body?

Hepatocellular carcinoma

9

What would arsenic cause on the skin?

SCC

11

What drug binds to FK-binding protein and inhibits calcineurin and secretion of IL-2?

Tacrolimus

12

What 2 environmental toxins can cause angiosarcoma of the liver?

Vinyl chloride and Arsenic

13

What is muromonab-CD3 used for?

Prevent acute transplant rejections

15

What drug is also known as rapamycin?

sirolimus

15

Which monoclonal antibody binds to CD3 to prevent T-Cell signal transduction?

Muromonab-CD3

15

What effect might vinyl chloride have on the body?

Liver angiosarcoma

17

What effect do nitrosamines have on the body?

Gastric Cancer

18

What is asbestos most likely to cause?

Bronchogenic carcinoma > mesothelioma

19

What effect might carbon tetrachloride have on the body?

Centrilobular necrosis and fatty change

20

Which antimetabolite is a precursor of 6-mercaptopurine?

Azathioprine

21

Which immunsuppressive drug has gingival hyperplasia as an AE? What anticonvulsant?

Cyclosporine; Phenytoin