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Flashcards in REPRODUCTIVE Deck (42):
1

What 2 antiandrogens are used to prevent hirsutism in PCOS?

Spironolactone and Ketoconazole

2

What is the controversy with DES?

Causes clear cell adenocarcinoma of vagina in females exposed in utero

3

What is the MOA of progestins?

Reduce growth and increase vascularization of the endometrium by binding progesterone receptors

4

What is the MOA of flutamide? What drug is it co-administered with to treat prostatic cancer?

Competitive antagonist for testosterone at the androgen receptor; administered with CONTINUOUS leuprolide

4

What are the 3 estrogen drugs?

Ethinyl estradiol, mestranol, and DES = Diethylstilbestrol

4

Which SERM increases the risk for cervical cancer? Which has no effect?

Tamoxifen, Raloxifene

4

What is the MOA and use of Mifepristone? What is it given with?

A competitive inhibitor of progestins at the endometrium? Used to terminate pregnancy. Given with misoprostol (PGE1)

5

Which SERM is used to induce ovulation?

Clomiphene

5

Which SERM is used for breast cancer and in preventing recurrences of Estrogen-Receptor positive breast cancer?

Tamoxifen

5

This drug inhibits the alpha 1 a, d receptor

Tamsulosin for BPH

6

In whom are OCP's contraindicated?

Smokers over 35 and ppl with Hx of thromboembolism

7

What is another name for RU-486?

Mifepristone--competitive inhibitor of progestins

9

This is a beta-2 agonist that relaxes the uterus and prevents premature contractions

Terbutaline

10

Which SERM is used mostly for osteoporosis?

Raloxifene

10

What is the use of tamsulosin? Receptor?

Treats BPH by inhibiting smooth muscle contraction? alpha 1a,d

12

Which OCP's cause thickening of the cervical mucus making sperm motility more difficult?

progestins

13

What is the MOA and use of terbutaline?

Beta-2 agonist that relaxes uterus and prevents premature contractions

15

MOA of testosterone and methyltestosterone

Agonist at androgen receptors

15

What is testosterone and methyltestosterone used for clinically?

Hypogonadism and forming secondary sex characteristics

15

AE of PDE-5 inhibitors (4)

Headache, flushing, dyspepsia (heart burn), and risk of hypotension with nitrates

16

How are ketoconazole and spironolactone anti-androgenics? What AE do they share?

Ketoconazole inhibits 17, 20 desmolase so inhibits steroid synthesis, Spironolactone prevents steroid binding? Both cause gynecomastia and amenorrhea

17

What kind of drug are anastrozole and exemestane?

Aromatase inhibitors

18

4 uses of leuprolide

Infertility = pulsatile, prostate CA = continuous and with flutamide, Uterine Fibroids (continuous) and Precocious puberty (continuous)

20

Which drugs inhibit phosphodiesterase 5? Phosphodiesterase 3?

Sildenafil, vardenafil etc.; Cilostazol and Dipyridamole

21

MOA of finasteride? Uses?

5-alpha reductase inhibitor (no DHT formed)? Tx of BPH and Male Pattern Baldness

22

How do synthetic estrogens and progestins act as oral contraceptives?

They inhibit LH and FSH via negative feedback and therefore prevent ovulation; also, progestins thicken cervical mucus which makes it difficult for sperm to get through

23

Name 2 aromatase inhibitors

Anastrozole and Exemestane

24

What are the 2 contraindications of estrogen therapy in women?

Hx of DVT's or ER (estrogen receptor) positive breast CA

25

What antiandrogen is used to treat prostate cancer?

flutamide

27

This GnRH analog is an agonist when used pulsatile and antagonist when continuous

Leuprolide

27

In the context of the reproductive system, what are spironolactone and ketoconazole used for?

Preventing hirsuitism in polycystic ovarian syndrome

28

Which drug can be used to shrink uterine fibroids?

Continuous leuprolide (GnRH analog)

30

What kind of drug is danozol?

Synthetic androgen acting as a partial agonist at androgen receptors

31

This is a synthetic partial agonist androgen used in endometriosus and hereditary angioedema

danozol

33

Which repro system drugs can cause blue-green vision?

PDE-5 inhibitors-- sildenafil and vardenafil

35

What kind of drug is mestranol?

An estrogen

36

What 2 drugs are used in conjunction for prostate cancer?

Leuprolide (GnRH analog used CONTINUOUSLY) and Flutamide (nonsteroidal competitive inhibitor of androgens at testosterone receptor)

37

When are estrogens used in men?

Androgen dependent prostate CA

38

What are the lipid effects of testosterone?

Increase LDL and decrease HDL

40

Which antiandrogenic drug inhibits 17, 20 desmolase?

Ketoconazole

41

List the 4 antiandrogens

Finasteride, Flutamide, Spironolactone, and Ketoconazole

42

What is the MOA of clomiphene to induce ovulation?

Partial agonist of estrogen receptors in hypothalamus causes release of LH and FSH (induces LH surge)