Flashcards in Drug Table - Microtubule inhibitors Deck (20)
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1
Microtubule Inhibitors
Inhibit mitosis and cause metaphase arrest
by interfering with microtubule function
(tubulin (de)polymerization); CCS
2
Vinblastine (Velban) Class
Vinca alkaloids
3
Vinblastine (Velban) Mech
Block tubulin polymerization into
microtubules
4
Vinblastine (Velban) Therapeutics
Metastatic testicular tumors (with
bleomycin, cisplatin); component of
ABVD used for Hodgkin's disease
5
Vinblastine (Velban) Other side effects
Myelosuppression, nausea,
vomiting
6
Vincristine (Oncovin) Class
Vinca alkaloids
7
Vincristine (Oncovin) Mech
Block tubulin polymerization into
microtubules
8
Vincristine (Oncovin) Therapeutics
Childhood ALL (with glucocorticoids);
Hodgkin's and non-Hodgkin's
lymphomas
9
Vincristine (Oncovin) Important side effects
Dose-limiting neurotoxicity
(peripheral neuropathy)
10
Vincristine (Oncovin) Other side effects
Relatively low bone marrow
toxicity
11
Paclitaxel (Taxol, Abraxane) Class
Taxanes
12
Paclitaxel (Taxol, Abraxane) Mech
Block microtubule depolymerization into
tubulin
13
Paclitaxel (Taxol, Abraxane) Therapeutics
Metastatic breast, ovarian, lung, and
head and neck cancers
14
Paclitaxel (Taxol, Abraxane) Imp side effects
Peripheral neuropathy
15
Paclitaxel (Taxol, Abraxane) other side effects
Neutropenia; hypersensitivity
reactions
16
Docetaxel (Taxotere) class
Taxanes
17
Docetaxel (Taxotere) Mech
Block microtubule depolymerization into
tubulin
18
Docetaxel (Taxotere) Therapeutics
Metastatic breast, ovarian, lung, and
head and neck cancers; hormone
refractory prostate cancer
19
Docetaxel (Taxotere) Important side effects
Peripheral neuropathy
20
