Drug Table - Microtubule inhibitors Flashcards Preview

Pharm Drug Table > Drug Table - Microtubule inhibitors > Flashcards

Flashcards in Drug Table - Microtubule inhibitors Deck (20)
Loading flashcards...
1

Microtubule Inhibitors

Inhibit mitosis and cause metaphase arrest
by interfering with microtubule function
(tubulin (de)polymerization); CCS

2

Vinblastine (Velban) Class

Vinca alkaloids

3

Vinblastine (Velban) Mech

Block tubulin polymerization into
microtubules

4

Vinblastine (Velban) Therapeutics

Metastatic testicular tumors (with
bleomycin, cisplatin); component of
ABVD used for Hodgkin's disease

5

Vinblastine (Velban) Other side effects

Myelosuppression, nausea,
vomiting

6

Vincristine (Oncovin) Class

Vinca alkaloids

7

Vincristine (Oncovin) Mech

Block tubulin polymerization into
microtubules

8

Vincristine (Oncovin) Therapeutics

Childhood ALL (with glucocorticoids);
Hodgkin's and non-Hodgkin's
lymphomas

9

Vincristine (Oncovin) Important side effects

Dose-limiting neurotoxicity
(peripheral neuropathy)

10

Vincristine (Oncovin) Other side effects

Relatively low bone marrow
toxicity

11

Paclitaxel (Taxol, Abraxane) Class

Taxanes

12

Paclitaxel (Taxol, Abraxane) Mech

Block microtubule depolymerization into
tubulin

13

Paclitaxel (Taxol, Abraxane) Therapeutics

Metastatic breast, ovarian, lung, and
head and neck cancers

14

Paclitaxel (Taxol, Abraxane) Imp side effects

Peripheral neuropathy

15

Paclitaxel (Taxol, Abraxane) other side effects

Neutropenia; hypersensitivity
reactions

16

Docetaxel (Taxotere) class

Taxanes

17

Docetaxel (Taxotere) Mech

Block microtubule depolymerization into
tubulin

18

Docetaxel (Taxotere) Therapeutics

Metastatic breast, ovarian, lung, and
head and neck cancers; hormone
refractory prostate cancer

19

Docetaxel (Taxotere) Important side effects

Peripheral neuropathy

20

Docetaxel (Taxotere) Other side effects

Neutropenia; hypersensitivity
reactions