Flashcards in Drug Table - Reproduction Deck (57)
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1
Class for:
Estradiol (valerate & cypionate)
Estrone sulfate
Equilin sulfate
Quinestrol
Estradiol esters
(steroidal)
2
Class for:
Ethinyl estradiol
Mestranol
Alkyl estrogen
3
Mechanism for:
Estradiol (valerate & cypionate)
Estrone sulfate
Equilin sulfate
Quinestrol
Ethinyl estradiol
Mestranol
Absorbed through skin, mucus membranes,
GI Tract; body-wide distribution via sexhormone
binding globulin
4
Therapeutics for:
Estradiol (valerate & cypionate)
Estrone sulfate
Equilin sulfate
Quinestrol
Ethinyl estradiol
Mestranol
Contraception, primary hypogonadism,
postmenopausal hormone therapy
5
Imp side effects for:
Estradiol (valerate & cypionate)
Estrone sulfate
Equilin sulfate
Quinestrol
Ethinyl estradiol
Mestranol
Weight gain, HTN; less commonly,
may cause breast cancer, DVT,
cervical and endometrial cancer
6
Other side effects for:
Estradiol (valerate & cypionate)
Estrone sulfate
Equilin sulfate
Quinestrol
Ethinyl estradiol
Mestranol
Nausea, breast tension/pain,
vaginal bleeding, headache
7
Misc for:
Estradiol (valerate & cypionate)
Estrone sulfate
Equilin sulfate
Quinestrol
Ethinyl estradiol
Mestranol
Strongly contraindicated in breast or
endometrial cancers, endometriosis,
undiagnosed vaginal bleeds;
relatively contradinicated in
pregnancy, thromboembolic disease,
HTN, hepatic disease, family history
of breast or uterine cancer
8
Diethylstilbestrol class
Non-steroidal
synthetic estrogen
9
Diethylstilbestrol Imp side effect
Increased risk of clear cell
adenocarcinoma of vagina & cervix
10
Tamoxifen citrate (Nolvadex) class
Non-steroidal antiestrogen;
selective
estrogen receptor
modifier
11
Tamoxifen citrate (Nolvadex) mechanism
Blocks estrogen from binding ER and
causing growth in ER(+) breast cancer
12
Tamoxifen citrate (Nolvadex) therapeutics
ER(+) breast cancer
13
Tamoxifen citrate (Nolvadex) imp side effects
Pro-estrogenic effect on uterine
epithelium (increase risk of
endometrial cancer); partial
estrogen agonist in bone and
endometrium
14
Tamoxifen citrate (Nolvadex) misc
Anti-estrogenic effect on mammary
epithelium; must be used in very
high doses
15
Clomiphene citrate (Clomid) class
Non-steroidal antiestrogen
16
Clomiphene citrate (Clomid) mechanism
Blocks estrogen binding to hypothalamic
receptors (no estradiol negative feedback
on gonadotropins) --> increased secretion
of gonadotropins & LH --> ovulation
17
Clomiphene citrate (Clomid) therapeutics
Stimulate ovulation in patients who
want to get pregnant
18
Clomiphene citrate (Clomid) imp side effects
Hot flashes, multiple pregnancy
19
Clomiphene citrate (Clomid) other side effects
Stomach pain, headache, upset
stomach, vomit
20
Clomiphene citrate (Clomid) misc
Cis-isomer (zuclomiphene) is a weak
estrogen agonist; trans-isomer
(enclomiphene) is a potent estrogen
antagonist
21
Class
Micronized progesterone
Transvaginal progesterone
Natural
progesterone
22
Therapeutics for
Micronized progesterone
Transvaginal progesterone
Contraception, hormone replacement
therapy
23
Imp side effects for
Micronized progesterone
Transvaginal progesterone
Fatigue, drowsiness
24
Misc for
Micronized progesterone
Transvaginal progesterone
Contraindicated in thromboembolic
disorders or patients with such a
history, liver disease (metabolised in
the liver), undiagnosed vaginal
bleeding, pregnancy (atrophy of
endometrium leading to birth
defects)
25
Class for:
Medroxyprogesterone
Norethindrone
Norgestrel
Megestrol
Synthetic
progesterone
26
Therapeutics for:
Medroxyprogesterone
Norethindrone
Norgestrel
Megestrol
Contraception, hormone replacement
therapy
27
Imp side effects for:
Medroxyprogesterone
Norethindrone
Norgestrel
Megestrol
Edema, abdominal bloating; less
commonly: strong androgenic
effects (hirsutism, acne)
28
Other side effects for:
Medroxyprogesterone
Norethindrone
Norgestrel
Megestrol
Anxiety, irritability, depression,
muscular pain; increased risk of
thrombus and PE
29
Misc for:
Medroxyprogesterone
Norethindrone
Norgestrel
Megestrol
Contraindicated in thromboembolic
disorders or patients with such a
history, liver disease (metabolised in
the liver), undiagnosed vaginal
bleeding, pregnancy (atrophy of
endometrium leading to birth
defects)
30