Drug Table - Reproduction Flashcards Preview

Pharm Drug Table > Drug Table - Reproduction > Flashcards

Flashcards in Drug Table - Reproduction Deck (57)
Loading flashcards...
1

Class for:
Estradiol (valerate & cypionate)
Estrone sulfate
Equilin sulfate
Quinestrol

Estradiol esters
(steroidal)

2

Class for:
Ethinyl estradiol
Mestranol

Alkyl estrogen

3

Mechanism for:
Estradiol (valerate & cypionate)
Estrone sulfate
Equilin sulfate
Quinestrol

Ethinyl estradiol
Mestranol

Absorbed through skin, mucus membranes,
GI Tract; body-wide distribution via sexhormone
binding globulin

4

Therapeutics for:
Estradiol (valerate & cypionate)
Estrone sulfate
Equilin sulfate
Quinestrol

Ethinyl estradiol
Mestranol

Contraception, primary hypogonadism,
postmenopausal hormone therapy

5

Imp side effects for:
Estradiol (valerate & cypionate)
Estrone sulfate
Equilin sulfate
Quinestrol

Ethinyl estradiol
Mestranol

Weight gain, HTN; less commonly,
may cause breast cancer, DVT,
cervical and endometrial cancer

6

Other side effects for:
Estradiol (valerate & cypionate)
Estrone sulfate
Equilin sulfate
Quinestrol

Ethinyl estradiol
Mestranol

Nausea, breast tension/pain,
vaginal bleeding, headache

7

Misc for:
Estradiol (valerate & cypionate)
Estrone sulfate
Equilin sulfate
Quinestrol

Ethinyl estradiol
Mestranol

Strongly contraindicated in breast or
endometrial cancers, endometriosis,
undiagnosed vaginal bleeds;
relatively contradinicated in
pregnancy, thromboembolic disease,
HTN, hepatic disease, family history
of breast or uterine cancer

8

Diethylstilbestrol class

Non-steroidal
synthetic estrogen

9

Diethylstilbestrol Imp side effect

Increased risk of clear cell
adenocarcinoma of vagina & cervix

10

Tamoxifen citrate (Nolvadex) class

Non-steroidal antiestrogen;
selective
estrogen receptor
modifier

11

Tamoxifen citrate (Nolvadex) mechanism

Blocks estrogen from binding ER and
causing growth in ER(+) breast cancer

12

Tamoxifen citrate (Nolvadex) therapeutics

ER(+) breast cancer

13

Tamoxifen citrate (Nolvadex) imp side effects

Pro-estrogenic effect on uterine
epithelium (increase risk of
endometrial cancer); partial
estrogen agonist in bone and
endometrium

14

Tamoxifen citrate (Nolvadex) misc

Anti-estrogenic effect on mammary
epithelium; must be used in very
high doses

15

Clomiphene citrate (Clomid) class

Non-steroidal antiestrogen

16

Clomiphene citrate (Clomid) mechanism

Blocks estrogen binding to hypothalamic
receptors (no estradiol negative feedback
on gonadotropins) --> increased secretion
of gonadotropins & LH --> ovulation

17

Clomiphene citrate (Clomid) therapeutics

Stimulate ovulation in patients who
want to get pregnant

18

Clomiphene citrate (Clomid) imp side effects

Hot flashes, multiple pregnancy

19

Clomiphene citrate (Clomid) other side effects

Stomach pain, headache, upset
stomach, vomit

20

Clomiphene citrate (Clomid) misc

Cis-isomer (zuclomiphene) is a weak
estrogen agonist; trans-isomer
(enclomiphene) is a potent estrogen
antagonist

21

Class
Micronized progesterone
Transvaginal progesterone

Natural
progesterone

22

Therapeutics for
Micronized progesterone
Transvaginal progesterone

Contraception, hormone replacement
therapy

23

Imp side effects for
Micronized progesterone
Transvaginal progesterone

Fatigue, drowsiness

24

Misc for
Micronized progesterone
Transvaginal progesterone

Contraindicated in thromboembolic
disorders or patients with such a
history, liver disease (metabolised in
the liver), undiagnosed vaginal
bleeding, pregnancy (atrophy of
endometrium leading to birth
defects)

25

Class for:
Medroxyprogesterone
Norethindrone
Norgestrel
Megestrol

Synthetic
progesterone

26

Therapeutics for:
Medroxyprogesterone
Norethindrone
Norgestrel
Megestrol

Contraception, hormone replacement
therapy

27

Imp side effects for:
Medroxyprogesterone
Norethindrone
Norgestrel
Megestrol

Edema, abdominal bloating; less
commonly: strong androgenic
effects (hirsutism, acne)

28

Other side effects for:
Medroxyprogesterone
Norethindrone
Norgestrel
Megestrol

Anxiety, irritability, depression,
muscular pain; increased risk of
thrombus and PE

29

Misc for:
Medroxyprogesterone
Norethindrone
Norgestrel
Megestrol

Contraindicated in thromboembolic
disorders or patients with such a
history, liver disease (metabolised in
the liver), undiagnosed vaginal
bleeding, pregnancy (atrophy of
endometrium leading to birth
defects)

30

Class for:
Monophasic Ortho-Novum
Biphasic Ortho-Novum
Triphasic Ortho-Novum

Combination pill