Drug Table - DNA Intercalating Agents Flashcards Preview

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Flashcards in Drug Table - DNA Intercalating Agents Deck (34)
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1

DNA Intercalating Agents
General Mechanism

Bind DNA through intercalation between
specific bases, blocking DNA, RNA or both
synthesis; cause DNA strands to break and
interfere with cell replication; CCNS

2

Dactinomycin (Actinomycin D, Cosmegen) Mech

Intercalates G-C base pairs of DNA,
interfering with DNA-dependant RNA
polymerase; also causes ssDNA breaks

3

Dactinomycin (Actinomycin D, Cosmegen) Therapeutics

Pediatric tumors (Wilms' tumor,
rhabdomyosarcoma Ewing's sarcoma);
choriocarcinoma in women

4

Dactinomycin (Actinomycin D, Cosmegen) Imp Side effects

Hematopoietic suppression with
pancytopenia

5

Dactinomycin (Actinomycin D, Cosmegen) Other side effects

Anorexia, nausea, vomiting

6

Daunorubicin (Cerubidine) Class

Anthracyclines

7

Daunorubicin (Cerubidine) Mech

Intercalate between DNA base pairs and
donate electrons to O2 to form superoxide;
superoxide reacts with itself to form H2O2 --
> cleaved in the presence of Fe to form OH
radical, which cleaves DNA

8

Daunorubicin (Cerubidine) Therapeutics

AML

9

Daunorubicin (Cerubidine) Imp Side effects

Irreversible dose-dependent
cardiotoxicity; alopecia

10

Daunorubicin (Cerubidine) Other side effects

Myelosuppression
(neutropenia), stomatitis, GI
disturbances

11

Daunorubicin (Cerubidine) Misc

Dexrazoxane is cardio-protective

12

Idarubicin (Idamycin) Class

Anthracyclines

13

Idarubicin (Idamycin) Mech

Intercalate between DNA base pairs and
donate electrons to O2 to form superoxide;
superoxide reacts with itself to form H2O2 --
> cleaved in the presence of Fe to form OH
radical, which cleaves DNA

14

Idarubicin (Idamycin) Therapeutics

AML

15

Idarubicin (Idamycin) Imp Side effects

Irreversible dose-dependent
cardiotoxicity; alopecia

16

Idarubicin (Idamycin) Other side effects

Myelosuppression
(neutropenia), stomatitis, GI
disturbances

17

Idarubicin (Idamycin) Misc

Dexrazoxane is cardio-protective

18

Doxorubicin (Adriamicin, Doxil) class

Anthracyclines

19

Doxorubicin (Adriamicin, Doxil) Mech

Intercalate between DNA base pairs and
donate electrons to O2 to form superoxide;
superoxide reacts with itself to form H2O2 --
> cleaved in the presence of Fe to form OH
radical, which cleaves DNA

20

Doxorubicin (Adriamicin, Doxil) Therapeutics

Sarcomas, breast and lung carcinomas,
malignant lymphomas

21

Doxorubicin (Adriamicin, Doxil) Imp side effects

Irreversible dose-dependent
cardiotoxicity; alopecia

22

Doxorubicin (Adriamicin, Doxil) Other side effects

Myelosuppression
(neutropenia), stomatitis, GI
disturbances

23

Doxorubicin (Adriamicin, Doxil) Misc

Dexrazoxane can be used to prevent
cardiotoxic effects

24

Epirubicin (Ellence) Class

Anthracyclines

25

Epirubicin (Ellence) Mech

Intercalate between DNA base pairs and
donate electrons to O2 to form superoxide;
superoxide reacts with itself to form H2O2 --
> cleaved in the presence of Fe to form OH
radical, which cleaves DNA

26

Epirubicin (Ellence) Therapeutics

Metastatic breast cancer, gastric
cancer

27

Epirubicin (Ellence) Imp side effects

Irreversible dose-dependent
cardiotoxicity; alopecia

28

Epirubicin (Ellence) Other side effects

Myelosuppression
(neutropenia), stomatitis, GI
disturbances

29

Epirubicin (Ellence) Misc

Dexrazoxane can be used to prevent
cardiotoxic effects

30

Bleomycin (Blenoxane) Mech

Acts in G2 phase of cell cycle. Binds to
DNA, producing ss- and dsDNA breaks