Flashcards in Drug Table - Hormone Therapy Deck (39)
Loading flashcards...
1
Prednisone (Meticorten) Class
Glucocorticoids
2
Prednisone (Meticorten) Mechanism
Inhibit mitosis in lymphocytes
3
Prednisone (Meticorten) Therapeutics
ALL; combination for Hodgkin's, non-
Hodkin's, multiple myeloma, and CLL
4
Dexamethasone (Decadron) Class
Glucocorticoids
5
Dexamethasone (Decadron) Mechanism
Inhibit mitosis in lymphocytes
6
Dexamethasone (Decadron) Therapeutics
Reduces edema in brain and spinal
cord tumors with radiation therapy
7
Tamoxifen (Soltamox) Class
Selective
estrogen-receptor
modulators
(SERMs)
8
Tamoxifen (Soltamox) Mechanism
Competes with estradiol for binding to
estrogen receptor
9
Tamoxifen (Soltamox) Therapeutics
ER-positive breast cancer, or as
adjuvant therapy following primary
breast tumor excision; prevention of
breast cancer in high-risk patients
10
Tamoxifen (Soltamox) Important side effects
Hot flushes, hair loss; increased
risk of endometrial cancer;
increased risk of thromboembolic
events
11
Tamoxifen (Soltamox) Other side effects
Nausea and vomiting
12
Fulvestrant (Faslodex) Class
Selective
estrogen-receptor
downregulators
(SERDs)
13
Fulvestrant (Faslodex) Mechanism
Binds with much higher affinity (>100-fold)
to estrogen receptor than tamoxifen,
inhibiting dimerization, increasing
degradation, and reducing overall ER levels
14
Fulvestrant (Faslodex) Therapeutics
Posmenopausal women with ERpositive
metastatic breast cancer
15
Aminoglutethamide (Cytadren) Class
Aromatase
inhibitors
16
Aminoglutethamide (Cytadren) Mechanism
Inhibits function of aromatase
17
Aminoglutethamide (Cytadren) Therapeutics
Relatively weak, used against breast
cancer
18
Aminoglutethamide (Cytadren) Imp side effects
Significant
19
Anastrozole (Arimidex) Class
Aromatase
inhibitors
20
Anastrozole (Arimidex) Mechanism
Inhibits function of aromatase
21
Anastrozole (Arimidex) Therapeutics
First-line for ER-positive breast cancer
in postmenopausal women
22
Letrozole (Femara) class
Aromatase
inhibitors
23
Letrozole (Femara) Mechanism
Inhibits function of aromatase
24
Letrozole (Femara) Therapeutics
ER-positive breast cancer in
postmenopausal women
25
Exemestane (Aromasin) class
Aromatase
inhibitors
26
Exemestane (Aromasin) Mechanism
Steroidal inhibitor of aromatase
27
Exemestane (Aromasin) Therapeutics
ER-positive breast cancer in
postmenopausal women
28
Leuprolide (Lupron) class
GnRH analogs
29
Leuprolide (Lupron) Mechanism
Binds GnRH receptor; inhibits release of
FSH & LH
30
Leuprolide (Lupron) Therapeutics
Androgen ablation therapy, along with
AR blockers
31
Goserelin (Zoladex) Class
GnRH analogs
32
Goserelin (Zoladex) Mechanism
Binds GnRH receptor; inhibits release of
FSH & LH
33
Goserelin (Zoladex) Therapeutics
Androgen ablation therapy, along with
AR blockers
34
Flutamide (Eulexin) Class
Nonsteroidal
androgen-receptor
blockers
35
Flutamide (Eulexin) Mechanism
Competes with androgen for AR binding
36
Flutamide (Eulexin) Therapeutics
Androgen ablation therapy, along with
GnRH analogs
37
Bicalutamide (Casodex) Class
Nonsteroidal
androgen-receptor
blockers
38
Bicalutamide (Casodex) Mechanism
Competes with androgen for AR binding
39
