Drug Table - Hormone Therapy Flashcards Preview

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Flashcards in Drug Table - Hormone Therapy Deck (39)
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1

Prednisone (Meticorten) Class

Glucocorticoids

2

Prednisone (Meticorten) Mechanism

Inhibit mitosis in lymphocytes

3

Prednisone (Meticorten) Therapeutics

ALL; combination for Hodgkin's, non-
Hodkin's, multiple myeloma, and CLL

4

Dexamethasone (Decadron) Class

Glucocorticoids

5

Dexamethasone (Decadron) Mechanism

Inhibit mitosis in lymphocytes

6

Dexamethasone (Decadron) Therapeutics

Reduces edema in brain and spinal
cord tumors with radiation therapy

7

Tamoxifen (Soltamox) Class

Selective
estrogen-receptor
modulators
(SERMs)

8

Tamoxifen (Soltamox) Mechanism

Competes with estradiol for binding to
estrogen receptor

9

Tamoxifen (Soltamox) Therapeutics

ER-positive breast cancer, or as
adjuvant therapy following primary
breast tumor excision; prevention of
breast cancer in high-risk patients

10

Tamoxifen (Soltamox) Important side effects

Hot flushes, hair loss; increased
risk of endometrial cancer;
increased risk of thromboembolic
events

11

Tamoxifen (Soltamox) Other side effects

Nausea and vomiting

12

Fulvestrant (Faslodex) Class

Selective
estrogen-receptor
downregulators
(SERDs)

13

Fulvestrant (Faslodex) Mechanism

Binds with much higher affinity (>100-fold)
to estrogen receptor than tamoxifen,
inhibiting dimerization, increasing
degradation, and reducing overall ER levels

14

Fulvestrant (Faslodex) Therapeutics

Posmenopausal women with ERpositive
metastatic breast cancer

15

Aminoglutethamide (Cytadren) Class

Aromatase
inhibitors

16

Aminoglutethamide (Cytadren) Mechanism

Inhibits function of aromatase

17

Aminoglutethamide (Cytadren) Therapeutics

Relatively weak, used against breast
cancer

18

Aminoglutethamide (Cytadren) Imp side effects

Significant

19

Anastrozole (Arimidex) Class

Aromatase
inhibitors

20

Anastrozole (Arimidex) Mechanism

Inhibits function of aromatase

21

Anastrozole (Arimidex) Therapeutics

First-line for ER-positive breast cancer
in postmenopausal women

22

Letrozole (Femara) class

Aromatase
inhibitors

23

Letrozole (Femara) Mechanism

Inhibits function of aromatase

24

Letrozole (Femara) Therapeutics

ER-positive breast cancer in
postmenopausal women

25

Exemestane (Aromasin) class

Aromatase
inhibitors

26

Exemestane (Aromasin) Mechanism

Steroidal inhibitor of aromatase

27

Exemestane (Aromasin) Therapeutics

ER-positive breast cancer in
postmenopausal women

28

Leuprolide (Lupron) class

GnRH analogs

29

Leuprolide (Lupron) Mechanism

Binds GnRH receptor; inhibits release of
FSH & LH

30

Leuprolide (Lupron) Therapeutics

Androgen ablation therapy, along with
AR blockers