Drugs 1

Question 1

BB common S/E (4)

Contraindications (4)

Answer 1

bronchospasm
cool peripheries
sleep disturbance
erectile dysfunction

sick sinus syndrome
uncontrolled heart failure
asthma
concurrent verapamil use

Question 2

Cautions (2) and contraindications to ACEi (1)
Specialist advice should be sought before starting ACE inhibitors in patients with?

Answer 2

Renovascular disease
Hereditary of idiopathic angioedema
Aortic stenosis CI

A potassium >= 5.0 mmol/L

Question 3

Ivabradine MOA

SE (4)

Answer 3

Blocks funny ion current in the SAN and reduced HR

visual effects
headache
bradycardia
heart block

Question 4

Amiodarone monitoring
Prior to treatment
Every six months

Answer 4

TFT, LFT, U&E, CXR prior to treatment
TFT, LFT every 6 months

Question 5

Amiodarone adverse effects (10)
Hints:
x4 organs
appearance
ECG
HR

Answer 5

thyroid dysfunction
corneal deposits
pulmonary fibrosis/pneumonitis
liver fibrosis/hepatitis
peripheral neuropathy, myopathy
photosensitivity
‘slate-grey’ appearance
thrombophlebitis and injection site reactions
bradycardia
lengths QT interval

Question 6

Inhibitors of P450 causes INR to?
Inducers of the P450 system causes the INR to

Answer 6

increase
decrease

Question 7

P450 inducers (therefore reduce efficacy of other drugs due to increased breakdown)

BullShit CRAP GPS

Answer 7

Barbiturates
St John Warts
Carbamezapine
Rifampacin
Alcohol (chronic)
Phenytoin
Griseofluvin
Phenobarbitol
Sulfonylureas + smoking

Question 8

P4550 inhibitors (therefore increase toxicity risk)

SICKFACES.COM

Answer 8

Sodium valproate
Isoniazid
Cipro
Ketoconazole
Fluconazole
Acute alcohol
Chloramphenicol
Erythro
Sulfonamides
Cimetidine
Omeprazole
Metronidazole

Question 9

Loop diuretics adverse effects (6)

Answer 9

Low Na, K+, Mg, Ca
Low BP
Renal impairment
Ototoxicity
Gout
Increased BM

Question 10

Which anti-anginal can cause ulcers?

Answer 10

Nicorandil

Question 11

Nicorandil SE (3)

CI

Answer 11

headache
flushing
skin, mucosal and eye ulceration
gastrointestinal ulcers including anal ulceration

left ventricular failure

Question 12

Adverse effects of carbimazole (2)

Answer 12

Agranulocytosis
Crosses the placenta but can be used in low doses in pregnancy

Question 13

SE GLP1 mimetics (2)

Answer 13

weight loss
severe pancreatitis

Question 14

Pioglitazone SE

CI

Answer 14

weight gain
liver impairment
fluid retention
bladder cancer

CI heart failure

Question 15

SGLT2 SE (4)

Answer 15

urinary and genital infection
fournier’s gangrene
increased risk of lower limb amputation
weight loss

Question 16

Orlistat SE (2)

Answer 16

Faecal urgency/ incontinence
Flatulence

Question 17

AZT adverse effects (3)

Answer 17

Bone marrow depression
Pancreatitis
Increased risk of non-melanoma skin ca

Question 18

AZT interacts with?

Answer 18

Allopurinol - lower doses of AZT should be used in this case

Question 19

Bisphosphonates adverse effects (4)

Answer 19

Oseophagitis + ulcers
Osteonecrosis of the jaw
Increased risk of stress fractures of proximal femoral shaft
Low calcium

Question 20

Denosumab SE (2)

Answer 20

diarrhoea
dyspnoea

Question 21

Common causes of drug induced lupus (2)

Answer 21

Procainamide
Hydralazine

Question 22

Adverse effects hydroxychloroquine

Answer 22

Bulls eye retinopathy (can result in severe and permanent visual loss)

Question 23

Leflunomide DMARD CI

Answer 23

pregnancy - contraception is needed whilst on it and for 2 years after for women and 3 months for men

Question 24

Leflunomide monitoring (3)

Answer 24

FBC, LFT and BP

Question 25

Leflunomide adverse effects (3)

Answer 25

Lung and liver issues HTN

Question 26

MTX adverse effects (5)

Answer 26

mucositis myelosuppression pneumonitis pulmonary fibrosis liver fibrosis

Question 27

MTX monitoring

Answer 27

FBC, U+E, LFTs before starting, weekly until stabilised, then every 2-3 months

Question 28

Sulfasalazine (4)

Answer 28

Rash Oligospermia Heinz body anaemia Interstitial lung disease

Question 29

Prednisolone (5)

Answer 29

Cushingoid Osteoporosis Impaired glucose tolerance HTN Cataracts

Question 30

Penicilliname can exacerbate which condition?

Answer 30

Exacerbation of myasthenia gravis

Question 31

Etanercept

Answer 31

Demyelination Reactivation of TB

Question 32

Prostaglandin analogues (latanoprost) SE (2)

Answer 32

Brown pigmentation of the iris Increase eyelash length

Question 33

Sympathomimetics e.g brimonidine in the rx of glaucoma Avoid taking with? SE

Answer 33

MAOI or TCAs Hyperaemia

Question 34

Pilocarpine SE (3)

Answer 34

Headache Constricted pupil Blurred vision

Question 35

SE rashes, oligospermia, headache, Heinz body anaemia, megaloblastic anaemia, lung fibrosis

Answer 35

Sulphasalazines

Question 36

Adverse effects of omeprazole (4)

Answer 36

1. Low sodium 2. Low magnesium 3. Osteoporosis 4. Increased risk of c.diff