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Flashcards in Drugs Deck (15)
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1

Carbidopa

Dopamine Decarboxylase inhibitor
Blocks decarboxylase in the intestine and peripheral
organs
Doesn't cross BBB
Reduces amt of L-DOPA needed
Drug for Parkinson's

2

Levodopa/Carbidopa

Combo often given
Dopamine Precursor/DDC inhibitor
Drug for Parkinson's

3

Pramipexole

Dopamine Receptor Agonist (D2 and D3)
Drug for Parkinson's
Usually not a replacement for L-DOPA/Carbidopa

4

Ropinirole

Dopamine Receptor Agonist (D2)
Drug for Parkinson's
Usually not a replacement for L-DOPA/Carbidopa

5

Amantadine

Dopamine Releaser-NMDA block
Facilitate the release of endogenous dopamine
Drug for Parkinson's

6

Kinds of drugs used to treat Parkinson's

Dopamine Precursors / DDC inhibitors
Dopamine Receptor Agonists
Dopamine Releaser-NMDA block
Anticholinergic Drugs
Monoamine Oxidase Inhibitors (prevent DA breakdown)
Catechol-O-Methyltransferase Inhibitors (prevent DA breakdown)

7

Drugs used in the treatment of glaucoma

Prostaglandin analogs, Alpha-2 adrenergic agonists, Beta-adrenergic antagonists, Carbonic anhydrase inhibitors, Cholinergic Receptor Agonists

8

Drugs for Tourette's syndrome

tetrabenazine, neuroleptics-aka dopamine receptor antagonis

9

Drugs for essential tremor

primidone, propranolol

10

Drugs for Huntington's

tetrabenazine, neuroleptics-aka dopamine receptor antagonist (haloperidol)

11

Prostaglandin analogs

Treatment of Glaucoma

Increase outflow of aqueous humor (Decr IOP)

First line medical therapy as part of stepped approach

12

Alpha-2 adrenergic agonists

Treatment of Glaucoma

Can be used as add-on second- or third-line therapy

Increases uveoscleral outflow of aqueous humor and inhibits the formation of aqueous humor

13

Beta-adrenergic antagonists

Treatment of Glaucoma

Next most common medical treatment after prostaglandin analogs

Reduce production of aqueous humor (decreased aqueous secretion from ciliary epithelium)

14

Carbonic anhydrase inhibitors

Treatment of Glaucoma

Can be used as add-on second- or third-line therapy.

Inhibition of carbonic anhydrase in the ciliary body epithelium reduces formation of bicarbonate ions which reduces fluid transport and IOP

15

Cholinergic Receptor Agonists

Treatment of Glaucoma

Historically important in glaucoma treatment but less commonly used today

Lower IOP by causing muscarinic receptor-induced contraction of ciliary muscle which facilitates aqueous outflow