Drugs Flashcards Preview

3rd Year General Revision > Drugs > Flashcards

Flashcards in Drugs Deck (41):
1

What class: phenelzine?

MAOI

2

What class: Isocarboxazid?

MAOI

3

What class: Tranylcypromine?

MAOI

4

What class: Moclobemide

RIMA

5

What class: Amitryptiline

TCA (non-selective)

6

What class: Clomipramine

TCA

7

What class: Imipramine

TCA (non-selective)

8

What class: Noritryptiline

TCA (NA selective)

9

What class: Dosulepin

TCA

10

What class: Fluoxetine

SSRI

11

What class: (Es)citalopram

SSRI

12

What class: Sertraline

SSRI

13

What class: Fluvoxamine

SSRI

14

What class: venlaxafine

SNRI

15

What class: duloxetine

SNRI

16

What class: Reboxetine

NARI

17

What class: Mirtazapine

NaSSA

18

Anterior cingulate

Attention/conflict/response selection

19

Orbitofrontal cortex

Relative reward preference/rule learning

20

Class of drug which could be used to treat premature ejaculation

SSRI

21

Which SSRI's inhibit CYP450?

Fluoxetine, paroxetine

22

Most common adverse effects of SSRIs

-sexual dysfunction
-GI (nausea, dyspepsia, constipation, diarrhoea)
-short term anxiety is fairly common
-in young people, there is probably an increased risk of self-harm (&suicide) in the first few weeks

23

TCA adverse effects

– Constipation
– Dry mouth
– Blurred vision
– Effects on cardiac function
– Postural hypotension (cholinergic and adrenergic blockade causing failure of peripheral orthostatic reflexes)

24

What does MAO A metabolise?

NA, 5-HT and tyramine

25

What does MAO B metabolise?

DA, tryamine and phenylethylamine

26

Name 3 irreversible MAOIs

Phenelzine
Isocarboxazid
Tranylcypromine

27

This type of drug is really good for atypical depression

MAOI

28

This type of drug results in increased NA and 5-HT storage and availability for release

MAOIS

29

Which foods could cause a tyramine crisis if you are on MAOIs?

Cheese, yoghurt, yeast extracts, meat, alcohol, broad beans, pickled herring

30

Symptoms of MAOI hypertensive crisis

Flushing headache, increased BP
-Rarely CVA

31

Treatment for MAOI hypertensive crisie

Alpha blockade --> PHENTOLAMINE / CHLORPROMAZINE !!! Learn !!!

32

Antipsychotic which may be antidepressant at low dose

Flupentixol

33

Types of mood stabiliser

Anti-convulsant drugs
"Atypical" antipsychotics
Others (lithium carbonate, NIMODOPINE)


-most mood stabilisers are anti-epileptic drugs (anti-convulsants)

34

How does lamotrigine work?

Blocks Na+ channels, although it doesn't work directly via GABA, the overall effect is to reduce excitability and cell firing (potentially useful if you have over-excitable neurones)
-Lamotrigine may also inhibit 5-HT (plus NA and DA uptake as well)

35

One of the oldest mood stabilisers
-method of action unkown

Lithium
-method of action unknown
-but probably to do with inhibition of glycogen synthase kinase 3 (GSK-3)

36

True anti-psychotic activity is related to their affinity for which receptor?

The D2 receptor
-desired effect is DA blockade in the mesolimbic systems

37

Why can you get adverse effects such as movement disorders and hyperprlactinaemia with anti-psychotics?

Due to the DA blockade in the nigrostriatal and tubero-infundibular pathways)

38

If you block the nigrostriatal pathways what happens?

Movement disorders

39

If you block the tubero-infundibular pathways, what happens?

Hyperprolactinemia

40

Which 5-HT receptors increase anti-psychotic affinity

5-HT2c and 5-HT2a

41

Which 5-HT receptors decrease anti-psychotic efficiency

5-HT1a