Flashcards in Drugs Deck (41):
What class: phenelzine?
What class: Isocarboxazid?
What class: Tranylcypromine?
What class: Moclobemide
What class: Amitryptiline
What class: Clomipramine
What class: Imipramine
What class: Noritryptiline
TCA (NA selective)
What class: Dosulepin
What class: Fluoxetine
What class: (Es)citalopram
What class: Sertraline
What class: Fluvoxamine
What class: venlaxafine
What class: duloxetine
What class: Reboxetine
What class: Mirtazapine
Relative reward preference/rule learning
Class of drug which could be used to treat premature ejaculation
Which SSRI's inhibit CYP450?
Most common adverse effects of SSRIs
-GI (nausea, dyspepsia, constipation, diarrhoea)
-short term anxiety is fairly common
-in young people, there is probably an increased risk of self-harm (&suicide) in the first few weeks
TCA adverse effects
– Dry mouth
– Blurred vision
– Effects on cardiac function
– Postural hypotension (cholinergic and adrenergic blockade causing failure of peripheral orthostatic reflexes)
What does MAO A metabolise?
NA, 5-HT and tyramine
What does MAO B metabolise?
DA, tryamine and phenylethylamine
Name 3 irreversible MAOIs
This type of drug is really good for atypical depression
This type of drug results in increased NA and 5-HT storage and availability for release
Which foods could cause a tyramine crisis if you are on MAOIs?
Cheese, yoghurt, yeast extracts, meat, alcohol, broad beans, pickled herring
Symptoms of MAOI hypertensive crisis
Flushing headache, increased BP
Treatment for MAOI hypertensive crisie
Alpha blockade --> PHENTOLAMINE / CHLORPROMAZINE !!! Learn !!!
Antipsychotic which may be antidepressant at low dose
Types of mood stabiliser
Others (lithium carbonate, NIMODOPINE)
-most mood stabilisers are anti-epileptic drugs (anti-convulsants)
How does lamotrigine work?
Blocks Na+ channels, although it doesn't work directly via GABA, the overall effect is to reduce excitability and cell firing (potentially useful if you have over-excitable neurones)
-Lamotrigine may also inhibit 5-HT (plus NA and DA uptake as well)
One of the oldest mood stabilisers
-method of action unkown
-method of action unknown
-but probably to do with inhibition of glycogen synthase kinase 3 (GSK-3)
True anti-psychotic activity is related to their affinity for which receptor?
The D2 receptor
-desired effect is DA blockade in the mesolimbic systems
Why can you get adverse effects such as movement disorders and hyperprlactinaemia with anti-psychotics?
Due to the DA blockade in the nigrostriatal and tubero-infundibular pathways)
If you block the nigrostriatal pathways what happens?
If you block the tubero-infundibular pathways, what happens?
Which 5-HT receptors increase anti-psychotic affinity
5-HT2c and 5-HT2a