Flashcards in DRUGS AND BONES Deck (9)
What do most drugs involved in treatment musculoskeletal disease target?
Inflammatory cells and inflammatory mediators
What derivative of arachidonic acid is often present at inflammatory sites?
What is the first step of treatment of RA?
NSAIDS and other analgesics (opioids)
These only treat the symptoms
What are side effects of cox 2 selective inhibitors?
Paradoxically they can can thrombosis
What are DMARDs?
Disease modifying anti-rheumatic drugs
What is the mechanism of methotrexate?
Competitive inhibition of dihydrofolate reductase
How often is methotrexate taken?
What are the side effects of methotrexate?
Bone marrow suppression
Interstitial lung disease
Acute cutaneous reactions