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Flashcards in DRUGS AND BONES Deck (9)
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0

What do most drugs involved in treatment musculoskeletal disease target?

Inflammatory cells and inflammatory mediators

1

What derivative of arachidonic acid is often present at inflammatory sites?

Cox 2

2

What is the first step of treatment of RA?

NSAIDS and other analgesics (opioids)
These only treat the symptoms

3

What are side effects of cox 2 selective inhibitors?

Paradoxically they can can thrombosis

4

What are DMARDs?

Disease modifying anti-rheumatic drugs

5

What is the mechanism of methotrexate?

Competitive inhibition of dihydrofolate reductase

6

How often is methotrexate taken?

Once weekly

7

What are the side effects of methotrexate?

Mouth ulcers
Nausea
Bone marrow suppression
Interstitial lung disease
Renal failure
Hepatitis
Acute cutaneous reactions

8

What must you screen for before giving an anti-TNF medication?

TB as it can be re activated whilst on these drugs