Drugs for GI infections II Flashcards Preview

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Flashcards in Drugs for GI infections II Deck (47)
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1

MOA bismuth subsalicaylate

bismuth coats ulcers and erosions forming protective barrier
atimulates PG, mucus, and HCO3
salicylate inhibites intestinal PG and Cl secretion (reduce stool frequency and liquidity in infecitous diarrhea)

2

therapeutic use bismuth subsalicylate

dyspepsia and acute diarrhea
travelers diarrhea
H pylor infection

3

adverse reactions from bismuth subsalicylate

harmless blackening of stool, liwuid could cause blackening of tongue
high doses: slaicylate toxicity, Reyes syndrome in kids
avoid in renal impairment

4

MOA fluoroquinolones

[ ] dep killing
targets bacterial DNA gyrase and topoisomerase IV

5

bacterial R to fluoroquinolones

mutation in bacterial chromosome genes encoding DNA gyrase or topoisomerase IV or by active trasnport out of the cell

6

fluoroquinolones work on what bacteria

E coli, salmonella, shigella, enterobacter, campylobacter, neisseria, pseudomonas, aeruginosa, S aureus

7

which fluoroquinolones work on strep spp

levofloxacin, gatifloxacin and moxifloxacin

8

therapeutic uses of fluoroquinolones

UTI, prostatisi, STI, travelers diarrhea, shigellosis, joint STTI infeciotns, DM foot infections

9

adverse effects fluoroquinolones

GI (nausea, vomiting, abdominal discomfort)
CNS(mild HA, dizziness, delirium, rare hallucinations)
rash, photosensitivity, Achilles tendon rupture

10

contraindications to fluoroquinolones

children because of achilles tendon rupture

11

MOA aminoglycosides

[ ] dependent, binds 30s ribosomeal subunit and disrupts normal cycle ribosomal funciton by interfering with initiation protein synthesis

12

bacterial R to aminoglycosides

AG metabolizing enzymes, impaired transport of drug into cell, altered ribosom

13

what microbesn are aminoglycosdes used against

aerobic gram - bacteria, limited action against gram +, produces synergistic bactericidal effects in gram + when combine with a cell wall active agent

14

GI uses aminoglycosides

UTI, peritonitis with peritoneal dialysis

15

adverse effects aminoglycosdes

ototoxicity, nephrotoxicity, neuromuscular block and apnea

16

what are the aminoglycosides

amikacin
tobramycin
gentamicin

17

MOA tetracycline

bacteriostatic, inhibits bacterial protein synthesis by binding 30s bacterial ribosome and preventing access of aminoacyl tRNA to acceptro A site on mRNA ribosome complex

18

bacterial R to tetracyline

decreased influx acquisition of energy dependent efflux, ribosomal protection proteins, enzymatic inactivation

19

spectrum tetracycline covers

aerobic and anaerobic gram + and gram -
also rickettsie, coxiella, mycoplasma, borrelia, treponema
Pseudomonas resistant

20

therapeutic use tetracyline

MRSA, rickettsial, CAP, Q fever, anthrax

21

adverse effects tetracycline

GI (epigastric burining, abdominal discomfort, nausea, vomiting, diarrhea, superinfecitons like C diff, photosensiticity, teeth discoloration

22

what are macrolides

azithromycin erythromycin

23

MOA macrolides

bacteriostatic, binds reversibly to 50s ribosomal subunit, inhibits translocation where a newly synthesized peptidyl tRNA molecule moves from acceptor site on ribosome to peptidyl donor site

24

bacterial R with macrolids

drug efflux, ribosomal protection proteins, hydrolysis, ribosomal mutaitons

25

spectrum covered by macrolides

aerobic gram + cocci, bacilli
clostridium , listeria monocytogenes

26

therapeutic use of macrolides

respiratory tract infections
alternative otitis media,s inusitis, bronchitis and SSTIs
pertussis, gastroenteritis
H pylori
mycobacterial infecitons

27

MOa metronidazole

prodrug that requires reductive activation by susceptible organisms

28

bacterial resistance to metronidazole

decreased formation of nitro radicals

29

spectrum metronidazole

anaerobic coccie and both anaerobic gram - bacilli and anaerobic spore forming gram + bacilli, trichomoniasis, amebiasis, giardiasis, Helicobacter and Campylobacter

30

Therapeutic use of metronidazole

bacterial vaginosis, amebic liver abscess, Tx anaerobic bacterial infections
part of regimen prophylazis coloretal surgery, C difficile, Crohns