drugs for GI infections I Flashcards Preview

Year2 GI Exam II > drugs for GI infections I > Flashcards

Flashcards in drugs for GI infections I Deck (45):
1

What are the fluoroquinolones

Ciprofloxacin
Levofloxacin

2

what are the antiprotozoals

metronidazole

3

what other antibiotics are available for GI infections

vancomycin, bactrim (trimethoprim-sulfamethoxazole

4

definition of diarrhea
acure, persisten chronic

>3 unformed stools/day
acute 30 days

5

what viruses cause diarrhea

noro and rota

6

what bacteria cause diarrhea

salmonella, campylobacter, shigella, EHEC, vibrio, yersinia, EAEC, ETEC

7

what protozoa can cause diarrhea

cryptosporidium, giardia, cyclospora, entamoeba, others

8

what pathogens can cause dysentery

shigella, salmonella, campylobacter, EHEC, yersinia and C difficile

9

what do you test for with bloody diarrhea and no fever or HUS

shiga toxin and EHEC

10

bloody diarrhea with recent immigration from tropical Africa, Asia or Latin Aerica

entamoeba histolytica

11

what bloody diarrhea is assoc with shellfish

vibrio

12

general approach to Tx of infectious diarrhea

prevention dehydration

13

Tx protocol for mild-moderate dehydration

oral rehydration therapy, superior to administratino of IV fluids

14

necesary compounds in oral rehydration therapy

carbs (glucose), Na, K, cl and water

15

Indiscriminant se of antimicrobials leads to increased risk of

antimicrobial Resistance, prolonged shedding of certain pathogens, Salmonella, C difficile
Side effects
superinfection after destruction of normal flora

16

what is rec antibiotic for mild to moderate travelers diarrhea

loperamide of bismuth subsalicylate alone

17

if travelers diarrhea is associated with fever or bloody stools, self tx with what antibiotics for how long

any of the floxacins for 3 days

18

what drug is used to tx noninvasive strains of E coli

rifaximin

19

what is Tx for quinolone R campylobacter

azithromycin

20

what antibiiotic use is assoc with C difficile

clindamycin, ampicilin, cephalosporins, fluoroquinolones, PPIs

21

hish risk groups C diff

elderly, debilitated, cancer, surgical

22

Tx options for C diff

metronidazole (PO or IV), vancomycin PO, fidazomicin

23

Vancomycin is preffered for when in C diff

severe infection
otherwise use metronidazole

24

how is vanco administered

PO

25

Tx campylobacteriosis

erythromcyin

26

if Diarrhea lasts longer than 7-10 days, most likley?

parasitic, giardia

27

Tx giardia

metronidazole

28

when is antibiotic Tx not recommended for diarrhea

EHEC, salmonella

29

why do not use antibiotics with salmonella

increase fecal shedding of pathogens and associated with prolonged carriage and relapse, does not reduce diarrhea

30

MOA idoquinol antiprotozoal

unknown, only effective on luminal organisms

31

therapeutic use idoquinol

adjunt to metronisazole in amebiasis

32

Adverse effects idoquinol

diarrhea, anorexia, nausea, comiting, abdominal pain, HA, rash, pruritis
may increase protein bound serum iodine
use caution in those with optic neuropathy, renal or thyroid disease or nonamebic hepatic disease

33

MOA nitazoxanide

inhibits pyruvate-ferredoxin oxidoreductase pathway

34

therapeutic use nitazoxanide

cryptosporidium
alternative to metronidazole in giardia

35

MOA paromomycin

interferes with bacterial protein synthesis by binding 30S ribosomal subunits
only luminal organisms

36

therapeutic use paromomycin

Tx acute and chronic intestinal amebiasis
off label cryptosporidium

37

adverse effects paromomycin

occasional abdominal distress and diarrea
may accumulate with renal insufficiency

38

MOA albendazole

antihelminthic
though to inhibit microtubule synthesis

39

wha tincreases absorption albendazole

fatty meals for tissue parasites
empty stomach for intraluminal parasites

40

therapeutic use albendazole

hydatid disease
cysticercosis
pinworm and hookworm infections: ascariasis, trichuriasis, strongyloides

41

therapeutic use rifaximin

prevention hepatic encephalopathy
travelers diarrhea from EHEC
off label IBS and refractory C difficile

42

MOA fidaxomicin

inhibits RNA polymerase resulting in inhibition protein synthesis causing cell death

43

PK of fidaxomicin

GI tract, undergoes intestinal hydrolysis to a less active metabolie

44

therapeutic use fidaxomicin

C difficile infection

45

adverse effects fidaxomicin

nausea, abdominal pain, vomiting
HS reacitons have been reported