GI Antibiotics - Kinder Flashcards Preview

Year2 GI Exam II > GI Antibiotics - Kinder > Flashcards

Flashcards in GI Antibiotics - Kinder Deck (43):
1

not treated with antibiotics

EHEC
salmonella

2

tx shigellosis

antibiotic tx reduces duration by 2.4 days

3

tx travelers diarrhea

mild to moderate
-loperamide or bismuth
-combine with fluoroquinolone

severe
-cipro, levo, norfloxacin, orfloxacin 3 day course

rifaximin - for noninvasive e coli

azithromycin - quinolone resistant campylobacter

4

tx c dif infection

metrondiazole - mild to moderate
vancomycin - severe

5

tx persistent diarrhea

suspect protozoal

giardia - tx metrondiazole

crypto hard to treat - especially in AIDS

6

colitis due to overgrowth of c dif

clincamycin, ampicillin, cephalosporins, fluoroquinolones, PPIs

7

metronidazole vs. vanco for c dif tx

metrondiazole - mild to moderate

vancomycin - severe

8

cipro MOA

inhibit DNA gyrase (topoisomerase II)

inhibit supercoiling gram-negative bacteria

also inhibit topoisomerase IV in gram positive organisms

9

cipro CI

don't use in kids - achilles tendon rupture

10

cipro side effect

nausea, vomiting, GI pain, rashes, fever

cartilage toxicity - achilles tendon rupture children

11

levo MOA

inhibit DNA gyrase (topoisomerase II)

inhibit supercoiling gram-negative bacteria

also inhibit topoisomerase IV in gram positive organisms

12

levo CI

dont use in kinds - achilles tendon rupture

13

levo side effect

nausea, vomiting, GI pain, rashes, fever

cartilage toxicity

14

trimethoprim sulfamethoxazole MOA

sulfonamide: bacteristatic and competetive inhibitors dihyropteroate synthase (needed for precursot to folic acid)
trimethoprim: inhibits microbial dihydrofolate reductase

15

trimethoprim sulfamethoxazole side effect

allergic skin rashes, nausea, comtiing, CNS, photosensitivity, renal dysfunction, Stevens-Johnson syndrome

16

metronidazole MOA

prodrug that requires reductive activation by susceptible organisms

don't really know

17

metronidazole clinical use

bacterial vaginosis, amebic liver abscess, Tx anaerobic bacterial infections
part of regimen prophylazis coloretal surgery, C difficile, Crohns

18

metronidazle side effect

HA, nausea, dry mouth, metallic taste, vomiting, diarrhea, abdominal distress!! esp with alcohol!!!
dizziness, vertigo, encephalopathy

19

vancomycin MOA

inhibits cell wasll synthesis binding with high affinity to D alanyl D alanine terminal cell wall unites

20

vancomycin clinical use

orally for C difficle

21

vancomycin side effect

macular skin rash, chills, fever, red man syndrome from rapid infusion
direct toxicity from vanco on mast cells causing release histamine
ototoxicity, nephrotoxicity

22

diarrhea length

acute < 14 days
persistant 14-29 days
chronic >30 days

23

bloody diarrhea

c dif

24

inflammatory diarrhea

fever, tenesums, dysentery

fecal leukocytes and fecal lactoferrin

25

tx diarrhea

prevent dehydration

26

mild to moderate dehydration

oral rehydration solution - superior to IV

27

ORS

glucose, Na, K, Cl, H20

28

shigellosis, travelers diarrhea, salmonella

bactrim - TMP/SMX

29

acute diarrhea

often viral

30

fruit juice, soda, gatorad

not good for ORS - too much sugar

31

cipro or levo use

travellers diarrhea

32

severe c dif

vancomycin

33

moderate c dif

metrondiazole

34

giardia

metrondiazole

35

salmonella

no antibiotics

unless immunocompromised

36

tissue parasites

albendazole with fatty meal

37

intraluminal organisms

albendazole on empty stomach

38

nitazoxanide

giardia

39

iodoquinol

antiprotozoal

40

paromomycin

anti-protozoal

41

anti-helminth

albendazole

42

travelers diarrhea

rifaximin

43

c dif

fidaxomicin