DSA Flashcards
(17 cards)
Where are the three places the sympathetic NS affects the kidneys?
- ) Afferent arteriole
- ) JG cells
- ) Tubular epithelial cells
What receptor is on the afferent arteriole?
a1
What receptor is on the JG cells?
b1
What receptor is on the tubular epithelial cells?
a1
What does sympathetic stimulation of the kidney arterioles cause?
Vasoconstriction
What does sympathetic stimulation of the JG cells cause?
Renin release and RAAS
What does sympathetic stimulation of the tubular epithelial cells cause?
Increased Na+ K+ ATPase activity and henceforth increased Na+ reabsorption
Tamm Horsfall Protein
Tamm-Horsfall glycoprotein (THP) is the most abundant urinary protein in mammals. Urinary excretion occurs by proteolytic cleavage of the part exposed at the luminal cell surface of the thick ascending limb of Henle’s loop
What estimates renal plasma flow? Why?
PAH. Bc we can assume all the PAH presented to the kidney will end up in the urine
Will reduced perfusion pressure stimulate or inhibit renin secretion?
Stimulate
Will increased perfusion pressure stimulate or inhibit renin secretion?
Inhibit
Does sympathetic nerve activity increase or decrease renin secretion?
Increase
Does sympathetic inactivity increase or decrease renin secretion?
Decrease
Does increased delivery of NaCl to the macula densa increase or decrease renin secretion?
Decrease
Does decreased delivery of NaCl to the macula densa increase or decrease renin secretion?
Increase
What 5 things cause afferent arteriole vasodilation?
Remember the mnemonic!
- Prostaglandins
- Bradykinin
- NO
- Dopamine
- ANP
“Peter Brady Never Does Anal”
What happens to creatinine if you increase GFR?
Decrease, they are opposite
