DVT/PE Flashcards Preview

Hugh's MD2 Core Conditions and Presentations > DVT/PE > Flashcards

Flashcards in DVT/PE Deck (20):
1

How do you reverse warfarin?

Prothrombin X (25 units per Kg)

FFP (one bag)

Vitamin K

2

What are some treatment options for PE?

Therapeutic clexane

Heparin

Alteplase

3

What is the mechanism of action of rivaroxaban?

Inhibitor of factor 10a

4

What are some presenting symptoms of PE?

SOB

Chest pain

Calf pain

Haemoptysis

Cough

 

5

What are some options for prophylaxis?

Chemical prophylaxis - exonaparin

Mechanical - TEDS, intermittent pneumatic compression

Early mobilisation

IVC filter

6

What is the mechanism of action of clopidogrel?

Blocks the P2Y12 receptor on platelets that ADP binds to

7

What constitutes major surgery?

Abdominal surgery >45minutes

8

What are some risk factors?

Hospialised/not ambulating

Pelvic/laproscopic surgery

Malignancy

Hypercoagulable states

Obesity

Pregnancy

9

What anticoagulation is required for stents?

Bare metal

- Life long aspirin

- 4 months clopridogrel

Drug eluding

- Life long aspirin

- 12 months clopridogrel

10

What is the mechanism of action of heparin?

It activates antithrombin III causing inactivation of thrombin and factor 10a and hence reduced clotting

11

When do you use an IVC filter?

Patient with Hx of DVT/PE where anticoagulation is contraindicated

12

Does chemical prophylaxis increase the risk of bleeding in surgery?

Not for major bleeds

Some haematomas

13

What is co-plavix?

Clopridogrel + aspirin

14

How does warfarin work?

Inhibits vitamin K reductase thereby blocking synthesis of vit K dependent clotting factors - 2,7,9, and 10

15

What is the mechanism of action of apixaban?

Factor 10a inhibitor

16

What is the mechanism of action of dabigitran?

Direct thrombin inhibitor

17

Why is laproscopic surgery higher risk for DVT?

Venous stasis

18

How long do you place someone on prophylaxis?

5-7 days or until fully mobile

Extended prophylaxis for major pelvic surgery/in the setting of malignancy

19

What are some primary disease of hypercoagulation?

Factor V leiden

Anti-phospholipid syndrome

Protein C/S deficiency

Lupus anticoagulant

20

What are the WELLS criteria? What is their purpose?

Symptoms of DVT (3pt)

Symptoms not attributable to another pathology (3pt)

Immobilisation (>3days) or surgery in prev four weeks (1.5pt)

Tachycard >100 (1.5pt)

PHx of DVT or PE (1.5pt)

Presence of haemoptysis (1pt)

Presence of malignancy (1pt)

 

To determine pretest probability when performing a CTPA - >6 is high risk and a CTPA can be performed without D-dimer