IBD Flashcards Preview

Hugh's MD2 Core Conditions and Presentations > IBD > Flashcards

Flashcards in IBD Deck (15):
1

When does Crohn's occur?

Usually in teens to 20s

But can be at any age

2

What are some extraintestinal manifestations of Crohn's?

Uveitis

Episcleritis

Seronegative spondyloarthropathy

Erythema nodosum

3

When does UC occur?

Peak at teens to 20s

Peak at 40s to 60s

4

What are some extraintestinal manifestations of UC?

Similar to Crohn's disease

Primary sclerosing cholangitis

5

PSC with UC = what?

Higher risk of colon cancer and cholangioma

6

How does smoking affect IBD?

Worse for Crohn's

Better for UC

7

How is Crohn's diagnosed? What is found?

Colonscopy and tissue diagnosis

- Transmural inflammation - mucosa to serosa, skip lesions

- Fat wrapping around the bowel

- Neutrophils, crypt abscesses, granulomas

8

In which IBD is perforation more likely?

Crohn's due to transmural inflammation

9

When is bowel cancer screening done in UC?

Yearly, starting 8 years after diagnosis

- Colectomy recommended if dysplasia is found

10

What is the treatment for proctitis UC?

Steroid enemas

11

When do you operate in Crohn's?

Perforation

Strictures

Fistulas

12

What are the histopathological findings in UC?

Crypt abscesses

Lymphocyte infiltrates without granulomas

Goblet cell depletion

13

What are the clinical features of UC?

Bloody diarrhoea

Tenesmus

Abdominal cramps

Fever

Weight loss

14

How is UC treated?

Sulphasalazine and steroids for flares

Azathioprin, infliximab for less controlled disease

Local therapy - suppositories or enemas

15

What is the histopathology of Crohn's?

Transmural inflammation with inflammatory cells (bluish infiltrates) extending from the ulcerated mucosa through submucosa and muscularis to the serosa, appearing as nodular granulomatous infiltrates on the serosal surface

(Robbins)