Dyslipidemias

Question 1

Which disorder? Accumulation of cholesterol in peripheral organs, orange tonsils

Answer 1

Tangier Disease

Question 2

Which disorder? Arcus cornealis, tendinous xanthomas, xanthelasma, increased destruction of LDL receptor

Answer 2

PCSK9 Gain of Function Mutation

Question 3

Which disorder? Autosomal dominant disorder resulting in defective or absent LDL receptor

Answer 3

Familial Hypercholesterolemia

Question 4

Which disorder? Causes of ABC-A1 mutations

Answer 4

Tangier Disease, Familial HDL deficiency

Question 5

Which disorder? Causes of hypertriglyceridemia

Answer 5

LPL deficiency, apoC2 deficiency

Question 6

Which disorder? Lipemia retinalis, eruptive xanthomas, hepatosplenomegaly

Answer 6

Hypertriglyceridemia

Question 7

Which disorder? Mutations in ApoA1 gene

Answer 7

Familial Hypoalphalipoproteinemia

Question 8

Which disorder? Plantar Xanthomas, premature atherosclerosis, ApoE mutation

Answer 8

Familial Dysbetalipoproteinemia

Question 9

Which disorder? Very low HDL-C mutations with corneal opacities

Answer 9

LCAT Deficiency

Question 10

Which drug class? Decrease degradation of LDL receptor in hepatocytes

Answer 10

PCSK9 Inhibitors

Question 11

Which drug class? Induce PPAR-alpha to increase intrahepatic beta oxidation

Answer 11

Fibrates

Question 12

Which drug class? Inhibits cholesterol absorption in the GI tract

Answer 12

Ezetimibe

Question 13

Which drug class? Inhibits HMG CoA reductase

Answer 13

Statins

Question 14

Which drug class? Lower LDL-C, raise HDL-C, and lower TGs

Answer 14

Niacin

Question 15

Which drug class? Prevent mixed micelle formation to partially reduce cholesterol absorption

Answer 15

Plant sterol and stanol esters

Question 16

Which drug class? Reduces enterohepatic circulation of bile acids

Answer 16

Bile Acid Sequestrants