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Flashcards in E2: GI Drugs Deck (48):
1

_________: Weak bases that interact with stomach acid to form water and salt

Antacids

2

Where do antacids work?

locally

3

What do antacids do to stomach pH?

raise gastric pH

4

Antacids Do NOT inhibit ____ production by parietal cells

HCl

5

Best antacids are those that buffer to a pH of ___-___

pH of 3-4

6

What is a SIDE EFFECT of Antacids?

Constipation

7

Which one of these combinations is TUMS? Aluminum hydroxide, magnesium hydroxide or calcium carbonate

Calcium Carbonate

8

What are the 2 Magnesium antacid products?

Milk of Magnesia,Maalox

9

Which antacid can be used to remineralize enamel? Watch out! it can cause a gun metal grey stain for a bit...

milk of magnesia

10

Which part of Maalox absorbs the H+ ions?

The SILICA (magnesium trisilicate)

11

Aluminum is astringent to stop bleeding

Aluminum

12

Watch out! Aluminum Antacids interfere with absorption of which antibiotic???

tetracyclines

13

BOARDS loves this antacid: Forms complexes with albumin, fibrinogen and globulin on ulcer surface, thus creating protective barrier to acid and pepsin.... Interferes with the absorption of many medications...Also binds pepsin directly....Not absorbed

SU-CRAL-FATE (Carafate)

14

Which drug is preferred by Gastroenterologists? (brand name and class)

ZANTAC-a Histamine H2 Receptor Antagonist

15

Which drug class binds to H+/K+-ATPase enzyme system in parietal cells?

Proton Pump Inhibitors

16

Proton Pump Inhibitors are for ____ term acid suppression that has a _____ pace of onset.

long term...slow

17

What are 3 really popular Proton Pump Inhibitors?

1.Nexium 2.Prevacid 3.Prilosec

18

NEXIUM is Better at healing _________ than Prilosec

erosive lesions

19

Think this might be important?? THIS drug is Indicated for use for prevention and treatment of NSAID-induced gastrointestinal lesions

Nexium (proton pump inhibitors)

20

DENTAL considerations!!! Antacids neutralize pH = interferes with absorption of many drugs = wait ___ hours

2 hours

21

WHICH DRUG does Histamine antagonists decrease?

antifungals

22

WHICH DRUG does Histamine antagonists alter?

warfarin

23

Proton pump inhibitors decrease absorption of systemic _______

antifungals

24

Excessive salivation: mediated by ______ nerve in response to excessive gastric acid coming into oral cavity

vagus nerve

25

Which disease are these people most susceptible to?Smokers, Heavy drinkers, Hyperparathyroidism, Renal dialysis patients, Use of NSAIDS (chronic use)

Peptic Ulcer Disease

26

Etiology of Peptic Ulcer Disease--__________ infection is Present in 90% of cases

Helicobacter pylori

27

DID YOU KNOW Helicobacter pylori resides in our ______?!

oral cavity!?!

28

Use of NSAIDS for > 1 month can cause this stomach condition.

peptic ulcer disease

29

H pylori associated with cancer of gastric mucosa = ________

lymphoma

30

Peptic ulcers RARELY undergo transformation to carcinoma, BUT Ulcers in __________ of stomach more likely to become malignant

greater curvature

31

Atrophic gastritis caused by chronic use of PROTON PUMP INHIBITORS increases risk for _______ cancer

stomach

32

What are the 4 Antibiotics used in combination to treat peptic ulcers?

TCAM 1. Tetracycline 2.CLARithromycin 3.Amoxicillin 4.Metronidazole

33

The standard first-line therapy is a one week TRIPLE therapy consisting of the antibiotics:

CA: CLARithromycin, amoxicillin...a proton pump inhibitor Nexium, Prevacid, Protonix, Aciphex..Prilosec

34

What happens if I hit the peptic ulcer with the triple thereby and the H Pylori is resistant?

levofloxacin (Levaquin) added as part of the therapy

35

AVOID ______ and _______ with Peptic Ulcer disease

Avoid aspirin, NSAIDS

36

What are the 2 Oral manifestations of peptic ulcer disease??

1. Vascular malformations of lip 2.Enamel erosion

37

________ antibiotics (erythromycin) cause GI distress and diarrhea = caution in patients with inflammatory bowel disease...IN FACT, they can cause THIS condition!

Macrolide antibiotics (erythromycin)...Pseudomembraneous colitis

38

What are the 2 distinct conditions of Irratable Bowel syndrome?

Ulceratic Colitis and Cj Crohn's disease

39

What 2 drugs are FIRST LINE against Tx of IBS?

Anti-inflammatories; corticosteroids

40

What are the 3 drugs to stay away from when Rx'ing to a IBS dental Pt?

CorticoSteroids, Immunosup drugs, aspirin/NSAIDS

41

cobblestone mucosal lesions

Crohn's Disease

42

Anti-Diarrheal: Bismuth subsalicylate (Pepto-Bismol)..Caution with _____ allergy

salicylate

43

codeine causes ________ as a side effect

constipation

44

loperamide(________)=OTC...Muscle relaxant...Relieves spasm and decreases gut motility

imodium

45

Laxatives: Bulk – carboxymethyl _______ with psyllium 􏰀 Absorb water to form softened stools by increasing bulk of intestinal contents

cellulose

46

Laxatives: Osmotic – _________ salts (magnesium citrate = OTC)...Used as prep for _________

magnesium...colonoscopy

47

Laxatives: Contact – bisacodyl (Dulcolax), _____ oil... bisacodyl also used in high doses as colonoscopy prep

castor

48

Laxatives: Lubricants – ______ oil, glycerin...Act as emollients

mineral