E4: Drug Abuse/Addiction Part IV Stimulants

Question 1

What are the two LEGAL stimulants?

Answer 1

Caffiene and Nicotine

Question 2

What is the drug of choice for MOST AMERICANS?

Answer 2

Caffiene

Question 3

HOW much of each will cause Caffeine withdrawals: coffee, tea, soda?

Answer 3

coffee: 1 cup tea: 2 cups soda:3 cans

Question 4

DO YOU SEE WHAT HAPPENS when you go off Caffeine???Symptoms appear within _______ of last caffeine use

Answer 4

12-24 hours

Question 5

DO YOU SEE WHAT HAPPENS when you go off Caffeine???Symptoms peak at ________

Answer 5

20-48 hours

Question 6

DO YOU SEE WHAT HAPPENS when you go off Caffeine???Symptoms last for _____ Headache, Flu-like symptoms, Depression, anxiety, Lethargy, fatigue

Answer 6

1 week

Question 7

Cocaine is a CNS STIMULANT with ________ properties

Answer 7

local anesthetic

Question 8

Cocaine is a POTENT _________

Answer 8

vasoCONSTRICTOR

Question 9

Cocaine Produces profound sense of _______

Answer 9

euphoria

Question 10

INTERESTING: Produces intense ________ dependency, but no _______ OR ________

Answer 10

psychological…tolerance OR withdrawal

Question 11

What are the 9 signs of cocaine use?

Answer 11

GB-T-ND-HHAT: 1.Gingival Bleeding/Recession Max PM 2.Bone Resorption in Max PM area 3.Tremors 4.NoseBleeds 5.Dilated Pupils 6.Hypertension 7.Headache 8. Alertness 9. Talkative!

Question 12

How long does Dilated Pupils take after Coke use?

Answer 12

45 minutes after use

Question 13

NEVER give EPI within ______ of COKE use

Answer 13

24 hours

Question 14

What causes Cocaine induced Gingival Necrosis?

Answer 14

The vasoContrictive effect of cocaine

Question 15

What are the 3 clinical uses for AMPHETAMINES?

Answer 15

1.Diet Pills 2.Energy Pills 3.Tx of ADHD

Question 16

What is the most common abused form of Amphetamine?

Answer 16

Methamphetamine (crystal meth)

Question 17

How can you MAKE methamphetamine?

Answer 17

Cook down pseudoEphedrine (sudafed)

Question 18

Which drug produces a LONGER duration of action: METH or COKE?

Answer 18

Meth

Question 19

Amphetamines stimulate which autonomic NS?

Answer 19

Sympathomimetics

Question 20

What is the drug for ADHD that blocks Reuptake of dopaminergic neurons?

Answer 20

Methyl-Phen-i-Date (Ritalin)

Question 21

What do you avoid when on Methyl-Phen-i-Date (Ritalin)?

Answer 21

avoid vasoconstrictors

Question 22

Which ADHD drug has minimal sympatic effect and blocks reuptake of dopaminergic neurons?

Answer 22

Pemoline (Cylert)

Question 23

Which ADHD drug blocks reup of BOTH dopamine and norepi?

Answer 23

Dextro-amphetamine (Dexadrine)

Question 24

What does dextroAmphetamine inhibit?

Answer 24

Monamine Oxidase (MAO)

Question 25

dextroAmphetamine Enhances sympathomimetic response of epinephrine/norepinephrine SO avoid _________

Answer 25

vasoconstrictors!!

Question 26

What is our only ADHD drug that is NOT an amphetamine?

Answer 26

A-TOM-OX-ET-INE (Straterra)

Question 27

Atomoxetine (adhd med) (not an amphetamine) Selectively inhibits reuptake of ________ with little to no activity at OTHER reuptake or receptor sites

Answer 27

norepinephrine

Question 28

Atomoxetine (adhd med) (not an amphetamine) May increase heart rate and blood pressure in presence of a pressor agent = use _________ with caution

Answer 28

vasoconstrictor...hmm common theme

Question 29

COOL! What is the name for Ecstasy???

Answer 29

MDMA (bath salts were MDPV)...MethyleneDioxyMethAmphetamine

Question 30

What was ecstasy first used for?

Answer 30

appetite suppressant

Question 31

Ecstasy is a stimulant _______ drug that induces ______

Answer 31

psychedelic...euphoria

Question 32

HOW does ecstasy induce euphoria?

Answer 32

alters SEROTONIN and DOPAMINE neurotransmission

Question 33

Ecstacy Enhances self-awareness and ability to ________ and can last ________

Answer 33

communicate ..... Duration of action = 4-6 hours

Question 34

What is the dental side effect of Ecstacy?

Answer 34

Trismus and bruxism

Question 35

What are the 3 fatal side effects of ecstasy?

Answer 35

1.cardio toxicity 2.hyperthermia 3.coagulopathy

Question 36

Which organ is affected most by ecstasy? (besides the brain yo!)

Answer 36

HepatoToxic

Question 37

Can you build a tolerance to Ecstacy?

Answer 37

YES

Question 38

Methamphetamine: A type of amphetamine used in the form of crystalline ________

Answer 38

hydrochloride...HCl (isn't that really acidic??)

Question 39

the Medical use for meth is its ______ form which is called:

Answer 39

dextrorotary form---dextroMethamphetamine (Desoxyn)

Question 40

What is dextromethamphetamine indicated for?

Answer 40

ADHD, Narcolepsy, obesity (short term)

Question 41

WHAT are the 3 neurotransmitters triggered when Meth enters the brain?

Answer 41

1.norepi 2.dopamine 3.serotonin

Question 42

Meth Prolongs presence of neurotransmitters in the synapse by inhibiting _______; stable against degradation

Answer 42

reuptake

Question 43

WEIRD WORD: Stimulates the _______ reward pathway, causing euphoria and excitement

Answer 43

mesolimbic

Question 44

The first time meth is used, the brain is flooded with _______ for INTENSE feelings of _______

Answer 44

dopamine.... pleasure

Question 45

T/F brain structure and function can be altered with chronic METH use.

Answer 45

TRUE

Question 46

METH: Acute physical effects = resemble "_______" response

Answer 46

“fight or flight”

Question 47

Methamphetamine is NEUROTOXIC = especially to WHAT TYPE of neurons????

Answer 47

dopaminergic

Question 48

WHY is meth neurotoxic to dopaminergic neurons?

Answer 48

Degradation of dopamine produces reactive oxygen species (“free radicals”) such as HYDROGEN PEROXIDE (get on that ketogenic diet SON!)

Question 49

Methamphetamine users often have unusual ________ of the skin on the face, arms and legs

Answer 49

lesions and scabbing

Question 50

What the hell is FORMICATION?

Answer 50

the sensation of insects crawling beneath the skin

Question 51

What are the three organs attacked by Meth? (other than the brain yo!)

Answer 51

1.lung 2.kidney 3.liver

Question 52

Meth: Hallucinations---Paranoia---Delusions---Thought disorders are called "_________"

Answer 52

amphetamine psychosis

Question 53

What are the 4 main warning signs of a kid on meth?

Answer 53

1.prolonged sleep 2.moodiness 3.depression 4.suicidal

Question 54

Meth is especially addictive when administered by ______ or ______

Answer 54

injected or smoked

Question 55

Do we have drugs to help break meth addiction, like heroin?

Answer 55

Nope :(

Question 56

Meth: Increasing frequency of use among ________ and young professionals

Answer 56

college students

Question 57

What was the main action of Combat Methamphetamine Act of 2005?

Answer 57

Requires retailers who sell ephedrine, pseudoephedrine and phenylpropanolamine to keep products behind the counter

Question 58

****Know these**** Clinical Signs of Meth Use (7)

Answer 58

HAD-B-MIX 1.HTN 2.Anorexia 3.Dilated Pupils 4.Bruxism 5.Moodiness 6.Increase Sweat 7.Xerostomia

Question 59

Meth Mouth- ______ of teeth and restorative materials

Answer 59

Erosion

Question 60

****Know these****Signs of Stimulant Overdose (8)

Answer 60

THE-HED-CH...1.Tremors 2.Hyperactive 3.Elevated Pulse 4.Hyperthermia 5.Extreme Sweating 6.Dilated Pupils 7.Cardiac Arrythmias 8.HTN

Question 61

Nicotine is a CNS _______ and is highly _______ (both physical and psychological)

Answer 61

STIMULANT...addictive

Question 62

*know* what are the 4 desired effects of nicotine?

Answer 62

1.increased alertness 2.muscle relaxation 3.facilitate concentration/memory 4.decreased appetite

Question 63

**know these** What are the 8 harmful effects of Nicotine?

Answer 63

NIC-HOLD-P.....1. Nausea/vomiting 2. Irritability 3.Coronary Artery Disease 4. HTN 5. Oral Cancer 6. Lung cancer 7.Dizziness 8.pulse

Question 64

Tobacco cessation requires ______ modification! Requires often __-__ attempts!

Answer 64

behavioral...5-8 attempts