E4: Migrane Drugs! Flashcards Preview

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Flashcards in E4: Migrane Drugs! Deck (19):
1

________ (5-HT) receptors are important for pain modulation

Serotonin

2

Serotonin receptors are found in WHAT TWO LOCATIONS?

Receptors are found pre-synapically and post-synaptically

3

Serotonin and Serotonergic Neurons In platelets = causes _________

vasoconstriction

4

In ____________ (PAG) = modulates nociception on a spinal level; stimulation- produced analgesia in midbrain
􏰀 Most projections from PAG are tryptaminergic

periaqueductal gray (PAG)

5

Serotonin and Serotonergic Neurons **modulates pain/nociception in ________ pathways

DESCENDING

6

Now known that ____ is involved in many behavioral and psychiatric disorders

5-HT

7

Data supports that migraine is caused by chronic ______ dysregulation

5-HT

8

______ Derivatives: ________ peripheral and cranial blood vessels

Ergot: Constricts

9

Ergot: Inhibits depolarization of dural blood vessel- associated ________

nociceptors

10

Ergot: Take ______ in onset because absorption and distribution are impaired as gastric symptoms of migraine increase. Addition of _______ speeds gastric absorption getting medication into the system more rapidly

early... caffeine THANK GOD

11

What are the two Ergot preps?

1.Ergot-amine 2.Ergot-amine and caffeine...blood vessel damage, gangrene

12

Longer half-life: chronic migraine; protracted, unresponsive migraine (in hospital care)

dihydro-ERGOT-amine (Migranal)

13

What was the first Triptan drug?

Suma-triptan

14

Selective agonists of 5-HT 1B and 5-HT 1D receptors in cranial arteries

Triptans

15

___________ = vasoconstrictor (like ergotamine)...acetaminophen = analgesic....dichloralphenazone = mild tranquilizing effect; central pain inhibitory effect

iso-meth-ept-ene (Midrin)

16

________: Phenothiazine derivatives (antipsychotics)....Control nausea and gastric irritation
with migraine....Tablet, suppository and parenteral forms....Antagonists of D2 receptors....May cause EXTRAPYRAMIDAL effects

AntiEmetics

17

THANK YOU LITTLE WAYNE: name one AntiEmetic

promethazine (Phenergan, Phenadoz, Promethegan)

18

What are the 8 drugs for migraine Prophylaxis?

5NAB-CT-CS....1. 5HT uptake inhibitors 2.NSAID 3.Antiseizure 4.Beta Blocker 5.Calcium Channel Blocker 6.Tricyclic antidepressant 7.CorticoSteroid 8.SSRI

19

Treat intractable migraine that has not
responded to other interventions

corticosteroids