Flashcards in E4: Migrane Drugs! Deck (19):
________ (5-HT) receptors are important for pain modulation
Serotonin receptors are found in WHAT TWO LOCATIONS?
Receptors are found pre-synapically and post-synaptically
Serotonin and Serotonergic Neurons In platelets = causes _________
In ____________ (PAG) = modulates nociception on a spinal level; stimulation- produced analgesia in midbrain
Most projections from PAG are tryptaminergic
periaqueductal gray (PAG)
Serotonin and Serotonergic Neurons **modulates pain/nociception in ________ pathways
Now known that ____ is involved in many behavioral and psychiatric disorders
Data supports that migraine is caused by chronic ______ dysregulation
______ Derivatives: ________ peripheral and cranial blood vessels
Ergot: Inhibits depolarization of dural blood vessel- associated ________
Ergot: Take ______ in onset because absorption and distribution are impaired as gastric symptoms of migraine increase. Addition of _______ speeds gastric absorption getting medication into the system more rapidly
early... caffeine THANK GOD
What are the two Ergot preps?
1.Ergot-amine 2.Ergot-amine and caffeine...blood vessel damage, gangrene
Longer half-life: chronic migraine; protracted, unresponsive migraine (in hospital care)
What was the first Triptan drug?
Selective agonists of 5-HT 1B and 5-HT 1D receptors in cranial arteries
___________ = vasoconstrictor (like ergotamine)...acetaminophen = analgesic....dichloralphenazone = mild tranquilizing effect; central pain inhibitory effect
________: Phenothiazine derivatives (antipsychotics)....Control nausea and gastric irritation
with migraine....Tablet, suppository and parenteral forms....Antagonists of D2 receptors....May cause EXTRAPYRAMIDAL effects
THANK YOU LITTLE WAYNE: name one AntiEmetic
promethazine (Phenergan, Phenadoz, Promethegan)
What are the 8 drugs for migraine Prophylaxis?
5NAB-CT-CS....1. 5HT uptake inhibitors 2.NSAID 3.Antiseizure 4.Beta Blocker 5.Calcium Channel Blocker 6.Tricyclic antidepressant 7.CorticoSteroid 8.SSRI