Eicosanoid and Alkaloids, Serotonin, Histamine Flashcards Preview

Pharmacology 2 > Eicosanoid and Alkaloids, Serotonin, Histamine > Flashcards

Flashcards in Eicosanoid and Alkaloids, Serotonin, Histamine Deck (42):
1

Histamine is formed from what AA?

Histidine

2

What substance is measured in urine to detect excess production of Histamine?

Imidazole acetic acid

3

Classic demonstration of Histamine effect

Wheal
flush
flare

4

Histamine receptor in smooth muscles

H1

5

Histamine receptor in stomach, heart, mast cells

H2

6

1st generation anti-H1 receptors

Diphenhydramine
Chlorpheniramine
Cyclizine
Meclizine
Promethazine

7

Difference between 1st gen and 2nd gen anti-H1

2nd gen has no autonomic or anti-motion sickness effects

8

H2-receptor antagonists

Cimetidine
Ranitidine
Famotidine
Nizatidine

9

Uses of Cimetidine

PUD
ZE syndrome
Gastroesophageal Reflux

10

DOC for acute migraine

Sumatriptan

11

Serotonin is produced from what AA

Tryptophan

12

Excess 5-HT in the body is detected by what in the urine

5-hydroxyindole acetic acid

13

5HT-1D/1B receptor agonists

Sumatriptan
Almotriptan
Eletriptan

14

5-HT3-receptor antagonists

Ondasetron
Granisetron
Dolasetron

15

Uses of Ondasetron

Chemotherapy and post-op vomiting

16

Additional use of Alosetron

Irritable bowel disease

17

5HT3-antagonist tha causes QRS and QT prolongation

Dolasetron

18

5HT2 receptor antagonist

Ketanserin

19

Vomiting center of the brain

Area postrema – floor of the 4th ventricle

20

Classification of ergot alkaloids

Vasoselective
Uteroselective
CNS-Selective

21

Vasoselective 5-HT2-receptor antagonist

Ergotamine
Methysergide

22

Uteroselective 5-HT2-receptor antagonist

Ergonovine
Methyergonovine

23

Causes marked smooth muscle contraction but blocks alpha-agonist vasoconstriction

Ergotamine
Ergonovine

24

Important group of endogenous FA derivatives that are produced from arachidonic acid

Eicosanoids

25

Straight-chain derivatives eicosanoids

Leukotrienes

26

Cyclic derivatives eicosanoids

Prostacyclin
Prostaglandins
Thromboxane

27

Inhibits Lipoxygenase

Zileuton

28

Used in synthesis of prostacyclin in the vascular endothelium and of prostaglandins important in renal function

COX-2

29

Leukocyte chemotaxis

LTB4

30

Slow-reacting substance of anaphylaxis

LTC4, LTD4

31

maintains PDA

PGE1

32

Platelet aggregation

TXA2

33

Exotropia,
Complete absence of facial expression

Moebius sequence – SE of Misoprostol

34

Straight-chain derivatives eicosanoids

Leukotrienes

35

Cyclic derivatives eicosanoids

Prostacyclin
Prostaglandins
Thromboxane

36

Inhibits Lipoxygenase

Zileuton

37

Used in synthesis of prostacyclin in the vascular endothelium and of prostaglandins important in renal function

COX-2

38

Leukocyte chemotaxis

LTB4

39

Slow-reacting substance of anaphylaxis

LTC4, LTD4

40

maintains PDA

PGE1

41

Platelet aggregation

TXA2

42

Exotropia,
Complete absence of facial expression

Moebius sequence – SE of Misoprostol