Endocrine disorders Flashcards Preview

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Flashcards in Endocrine disorders Deck (21):
1

how is diabetes diagnosed

blood gluoselevels
grey tube EDTA

2

fasting glucse normal evel

7

3

random plasma glucose diabetes level

above 11

4

glucosetolerance test

75g given orally
measured after 2hrs for clearance rates

5

diabetes mellitus diagnostic indicator

haemoglobin become glycated (HbA1c) and this reflects the glucose levels over 2-3 months and is used as a diagnostic indicator

6

excess insulin

insulinoma, benign tumour that causes hypoglycaemia

7

diagnosis of insulioma

prolonged fasting and measuring proinsulin levels

8

how is an insulinoma treated

surgical removal
oral diazoxide

9

HPT axis

ypo-pit-thyroid axis
Hypothalamus makes TRH
Pituitary releases TSH
Goes to thyroid to then release T4
T4 isn't reactive form so converted into T3 by liver or kidney
Active form now
Works slowly, long term regulation
Feedback loop affect hypothalamus

10

hypothyroidism

low T3/4 hormones but more TRH and TSH as no neg feedback loop
everything slow
sllowHR
weight gain
tiredness
costiapaton
slow thinking

11

hyperthryoidism

too much T3/4 leading to low TRH and TSH
everything fast
-fast HR
-weight loss
- diarrhoae

12

primary adrenal insufficency

addinsons disease
- lack of cortisol
-failure of adrenals
- treated with steroid replacement

13

clinical signs of addinsons disease

- lethargy
- hyperpigmentation
- abdominal pain
- ddhydration

14

diagnosis of addinsons disase

measure serum cortisol and electrolytes, they will be low
short synacthen test

15

short synacthen test

dynamic function test
synacthen is analogue of ATCH which s given and then samles are taken to test for cortisol levels
in addinsons, little o nw cortisol made after the test

16

cushings disease

excess corisol

17

diagnosic test for cushings syndrome

dexametasome supression test
dynamic function test
- adminster dexamethasome
- in nroam cortisol should be supressed
in chusnds it will be excess

18

causes of cushings syndrome

adrenal tumour
pituitary tumour
ectopic tumour making ATCh

19

excess GH in adults

giagntism

20

hyperprolactinamia

high serum prolactin

21

treatment of hyperproactinaemia

- rugs to supress prolactin secretion and shrink a tumour
-surgery to remove pituitaryparts