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Flashcards in Endocrine Drugs Deck (19):
1

Differentiate Wolf-Chaikoff effect from Job-Basedow phenomenon.

Wolf-Chaikoff effect: ingestion of iodine causes hypothyroidism
Job-Basedow phenomenon: ingestion if iodine causes hyperthyroidism

2

Which antithyroid drug inhibit peripheral conversion to T4 to T3?

Propylthiouracil
Propranolol
Hydrocortisone

3

What drug can cause drug-induced hyperthroidism?

Clofibrate
Amiodarone
Methadone

4

Addison VS Conn

Addison's = Adrenal insufficiency
Conn's = adrenal exCess

5

Mnemonics-Progestins

NORgestimate, NORerthindrone and NORgestrel are NOT ESTROGENS. They are PROGESTINS!

6

Mnemonics-Tamoxifen

TAnggal Mammary Mo = TAMOxifen

7

Mnemonics-Clomiphene

Clone Me Phlease = Clomiphene

8

Mnemonics-Flutamide

Flutamide = Fake Androgen

9

Mnemonics-Flutamide

FinAsteRIde = Five Alpha Reductase Inhibitor

10

Mnemonics-Insulin Preparations

LISpro = mabiLIS
gLARGine = Go Large!
LANTus = LANTa na sa sobrang tagal!

11

Why is there paradoxical improvement of diabetes in patients with end-stage renal disease?

insulin has prolonged half life due to decreased clearance

12

Which patients are more prone to developing hypoglycemia with insulin use?

advanced renal disease
elderly
children younger than 7 years

13

Why are the only routes of administration for insulin subcutaneous and IV?

TRANSDERMAL --> does not result in a reproducible and sufficient transfer of insulin across the skin
ORAL --> lack of a specific peptide carrier system in the gut
INTRANASAL --> bioavailability was low ang metabolic effect lasted too short to be of clinical usefulness
INTRAMASCULAR --> overall metabolic response not comparable to SC
INHALATION --> most promising; comparable to SC and IV but is still presently in Phase III trials (Exubera)

14

Mnemonics-Pioglitazone

PIOGlitazone = pampa-POGI ng INSULIN para di mo na ma-resist

15

Are BANGKOK PILLS safe for weight loss?

BANGKOK PILLS
ephedrine, fenfluramine, phentermine
adverse effect: valvular heart disease

16

Describe the function of Osteoblasts and Osteoclasts.

osteoBlast = Builds Bone
osteoclasts = CLeaves / resorbs Bone

17

Mnemonics-Parathyroid Hormone

ParaThyroid Hormone (PTH)
Phosphate
Thrashing
Hormone

18

What are the signs and symptoms of Excess PTH?

Painful bones
Renal stones
Abdominal groans
Psychiatric overtones

19

Mnemonics-Calcitonin

CalciTONin = TONes down Calcium (reduces blood Ca, decrease bone resorption) NONHORMONAL REGULATORS