Flashcards in Hematologic, DMARDS, and NSAIDs Drugs Deck (12):
What are the neurologic defects of vitamin B12 deficiency?
Ataxic gait (SCT)
Impaired position (DC) and Vibratory (LCST) sense
How many 500 mg Aspirin tablets must be ingested to produce toxicity? death?
toxic dose = 150 mg/kg
150 mg/kg x 70 kg / 500 mg/tab = 21 tabs
lethal dose = 500 mg/kg
500 mg/kg x 70 kg / 500 mg/tab = 70 tabs
What is the triad of aspirin hypersensitivity?
What is the expected acid-base abnormality in salicylate poisoning?
Respiratory Alkalosis with HAGMA
What is the difference between in presentation of aspirin intoxication in children and adults?
ADULTS=mixed acid-base disorder (Respiratory Alkalosis with HAGMA)
CHILDREN=pure acid-base disorder (HAGMA)
What is the difference between an inhibitor and an uncoupler of oxidative phosphorylation?
INHIBITORS: completely halt ETC
UNCOUPLERS: dissipate proton gradient without interrupting ETC
What laboratory tests will you request to assess the extrinsic and intrinsic coagulation pathways?
PiTT = PTT for intrinsic pathway
Pet = PT for extrinsic pathway
In patients requiring anticoagulation, why is an overlap between heparin and warfarin usually done?
-warfarin's effect requires elimination of preformed clotting factors (8-60h)
-to bypass the initial prothrombotic effect of warfarin (skin necrosis)
What is stage I of paracetamol Overdose?
0.5 to 24 hours --> nausea, vomiting, diaphoresis, pallor, lethargy, malaise
What is stage II of paracetamol Overdose?
24 to 72 hours --> elevated liver enzymes, oliguria, azotemia, increased PT, hyperbilirubinemia
What is stage III of paracetamol Overdose?
72 to 96 hours --> jaundice, hepatic encephalopathy, bleeding diatheses, acute tubular necrosis, HAGMA, coma, death