Hematologic, DMARDS, and NSAIDs Drugs Flashcards Preview

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Flashcards in Hematologic, DMARDS, and NSAIDs Drugs Deck (12):
1

What are the neurologic defects of vitamin B12 deficiency?

Ataxic gait (SCT)
Impaired position (DC) and Vibratory (LCST) sense
Spasticity

2

How many 500 mg Aspirin tablets must be ingested to produce toxicity? death?

toxic dose = 150 mg/kg
150 mg/kg x 70 kg / 500 mg/tab = 21 tabs

lethal dose = 500 mg/kg
500 mg/kg x 70 kg / 500 mg/tab = 70 tabs

3

What is the triad of aspirin hypersensitivity?

SAMTER TRIAD
Asthma
Aspirin sensitivity
Nasal polyps

4

What is the expected acid-base abnormality in salicylate poisoning?

Respiratory Alkalosis with HAGMA

5

What is the difference between in presentation of aspirin intoxication in children and adults?

ADULTS=mixed acid-base disorder (Respiratory Alkalosis with HAGMA)
CHILDREN=pure acid-base disorder (HAGMA)

6

What is the difference between an inhibitor and an uncoupler of oxidative phosphorylation?

INHIBITORS: completely halt ETC
UNCOUPLERS: dissipate proton gradient without interrupting ETC

7

What laboratory tests will you request to assess the extrinsic and intrinsic coagulation pathways?

PiTT = PTT for intrinsic pathway
Pet = PT for extrinsic pathway

8

In patients requiring anticoagulation, why is an overlap between heparin and warfarin usually done?

-warfarin's effect requires elimination of preformed clotting factors (8-60h)
-to bypass the initial prothrombotic effect of warfarin (skin necrosis)

9

What is stage I of paracetamol Overdose?

0.5 to 24 hours --> nausea, vomiting, diaphoresis, pallor, lethargy, malaise

10

What is stage II of paracetamol Overdose?

24 to 72 hours --> elevated liver enzymes, oliguria, azotemia, increased PT, hyperbilirubinemia

11

What is stage III of paracetamol Overdose?

72 to 96 hours --> jaundice, hepatic encephalopathy, bleeding diatheses, acute tubular necrosis, HAGMA, coma, death

12

What is stage IV of paracetamol Overdose?

4 days to 2 weeks --> recovery