Basic Principles Flashcards Preview

Pharmacology > Basic Principles > Flashcards

Flashcards in Basic Principles Deck (19):
1

Mnemonics: Heparin

Heparin is Large
MOA increase Antithrombin III
Monitored using PTT
Antidote is Protamine Sulfate

2

Mnemonics:
Endocytosis vs Pinocytosis

Endocytosis = Cell Eating
Pinocytisis = Cell Drinking

3

Mnemonics: pKa

UP above
Unprotonated > Protonated: above pKa

4

Mnemonics - Bicarbonate and Ammonium Chloride

Alkalinizing Agent=Basic=give Bicarbonate
ACidifying Agent=ACidic=Ammonium Chloride

5

Which quadrant of the buttocks is safest fro IM drug administration?

superolateral=safe
superomedial=gluteus medius gait
inferomedial=sciatica

6

Through which blood vessels do drugs administered SL pass before reaching the heart?

lingual vein --> IJV --> branchiocephalic (innominate) vein --> SVC --> RA

7

Why is the only partial bypass of the first pass-effect on rectal administration?

Review the VENOUS DRAINAGE OF THE RECTUM.
Superior Rectal Vein: IMV --> PV (first-pass)
Middle Rectal Vein: IIV --> IVC
Inferior Rectal Vein: IPV --> IIV --> IVC

8

Mnemonics-Nitric Oxide

JoyOUS = HAPPY = NitrOUS oxide = laughing gas

9

Describe Acute inflammation

Drying agents (tinctures, wet dressings and lotions)

10

Describe Chronic inflammation

Lubricating agents (creams, ointments)

11

What routes of drug administration:
undergo significant first-pass effect?
partially bypass the first-pass effect?
complete bypass the first-pass effect?

-oral
-rectal
-IV, IM, SC, SL, inhalation, topical, transdermal

12

What drugs display zero order elimination kinetics?

WHAT PET
Warfarin
Heparin
Aspirin
Tolbutamide
Phenytoin
Ethanol - at high concentration
Theophylline

13

Which drug displays first-order elimination?
zero-order elimination?

0h 1hr 2h 3h 4h

80 60 40 20 0

80 40 20 10 5

14

What drugs displaytachyphylaxis?

MEDical Students Love to watch CNN in HD!
Metoclopramide
Ephedrine
Dobutamine
LSD
Calcitonin
Nitroglycerin
Nicotine
Hydralazine
Desmopressin

15

After oral administration of 500mg of Drug A, only 300mg were absorbed into the patient's systemic circulation. What is its bioavailability?

300/500= 60%

16

A drug is 50% cleared by the kidney and 50% by the liver . Its normal dosage is 200mg/d. What is the corrected dosage in a patient with a creatinine clearance of 20mL/min?

Dosage = 100mg/d +100mg/d x 20/100
Dosage = 120mg/d

17

Mnemonics-Phase I Reactions

A HORDe of PHASE I REACTIONS
Hydrolysis
Oxidation
Reduction
Deamination

18

Mnemonic-Cytochrome P450 Inducers --> Metabolism is faster

Ethel Booba takes Phen-Phen and Refuses Greasy Carb Shakes
Ethanol
Barbiturates
Phenytoin
Rifampicin
Griseofulvin
Carbamazepine
St. John's Wort / Smoking

19

Mnemonics-Cytochrome P450 Inhibitors

Inhibitors Stop Cyber Kids from Eating GRApefruit Q
Isoniazid
Sulfonamides
Cimetidine
Ketoconazole
Erythromycin
Grapefruit Juice
Ritonavir
Amiodarone
Quinidine