Autonomic Pharmacology Flashcards Preview

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Flashcards in Autonomic Pharmacology Deck (31):
1

Mnemonic:PLASMA (for parasympathetic nervous system):

PLASMA
Parasympathetic NS
Long preganglionic fibers
Acetylecholine
Short postganglionic fibers
Acetylcholine

2

Mnemonic: point and Shoot

Point (Erection) = Parasympathetic NS
Shoot (Ejaculation) = Sympathetic NS

3

Mnemonics-Betanechol

B = Bethanechol = Bowel & Bladder Atony

4

What is Sjogren Syndrome?

autoimmune disorder characterized by triad of
-xerostomia (dry mouth)
-xerophthalmia (dry eyes)
-rheumatoid arthritis

5

What is myasthenia gravis?

autoimmune destruction of nicotinic ACh receptors, characterized by:
-fluctuating muscle
-weakness
-ocular symptoms
-bulbar symptoms
-proximal muscle weakness

6

Differentiate myasthenic crisis from cholinergic crisis.

Myasthenic Crisis
-acute worsening of symptoms due to infection, stress or UNDERmedication
Cholinergic Crisis
-excessive activation of cholinoceptors (skeletal muscle weakness and parasympathetic signs) due to OVERmedication

7

How does EDROPHONIUM differentiate myasthenic crisis from cholinergic crisis?

-IMPROVES muscle strength in myasthenic crisis
-WEAKENS muscle strength in cholinergic crisis

8

What are the signs and symptoms of organophosphate poisoning?

DUMBBELSS
Diarrhea
Urination
Miosis

Bronchospasm
Bradycardia
Excitation (skeletal muscle and CNS)
Lacrimation
Sweating
Salivation

9

Mnemonics- Cycloplegia and Mydriasis

C=cycloplegia = Ciliary muscle paralysis = loss of Accomodation Mydriasis = Dilate (or you dilate your mouth when you say mydriasis)

10

Mnemonics-Muscarinic Antagonists for Parkinsonism

Try to Park your Benz, beep here.
-TRIhexyphenidyl
-BENZtropine
-BIPeriden

11

Why is ipratropium the preferred bronchodilator in patients with comorbid COPD and heart disease?

-less likely to cause tachycardia and
-cardiac arrhythmias

12

Mnemonics-Atropine Toxicity

-HOT as a hare
-DRY as a bone
-RED as a beet
-BLIND as a bat
-MAD as a hatter

13

Mnemonics-Succinylcholine

Kapag nakapag-DEPOsit ka sa toilet, SUCCess yun. (DEPOlarizing = SUCCinylcholine)

14

Mnemonics-Dopamine/Norepinephrine

dopamine vasoDILATES renal blood vessels while norepinephrine vasCONSTRICTS them

15

Mnemonic- Beta receptors

You have 1 heart and 2 lungs
B1 is for the heart, B2 is for the lungs

16

Clinical Condition
-acute heart failure
septic shock

Desired Parameter
-increased cardiac output --> B1 and D1 agonists

17

Clinical Condition
-hemostasis
decongestion
spinal shock

Desired Parameter
vasocontriction
temporary
maintenance of BP --> a1 agonist

18

Clinical Condition
bronchospasm
premature labor

Desired Parameter
bronchodilation
uterine smooth
muscle relaxation --> B2 agonist

19

Clinical Condition
-hypertension
glaucoma

Desired Parameter
decrease BP --> a2 agonist

20

What is the pharmacologic advantage of a1 sensitivity?

-reflex tachycardia is less common and less severe

21

Mnemonics-Isoproterenol

ISOproterenol is NOT a beta blocker.
It is a nonselective beta agonist.
I SOrry! akala ko beta blocker ka!

22

Menmonics -Beta blockers with ISA

ISA PA! Isa pa! Isa pang CHICKEN JOY!
Intrinsic Sympathomimetic Activity = Pindolol, Acebutolol

23

Mnemonics-Nadolol

NADOLOL=NAsa DOLO = longest half-life

24

Mnemonics-Esmolol

ESMOLOL=ESMOL = short / small half-life

25

Treatment of Glaucoma
Drug Class
-Beta Blocker

Examples
TIMOLOL --> Decreased secretion of aqueous humor from the ciliary epithelium

26

Osmotic agents

MANNITOL --> Decreased secretion of aqueous humor from the ciliary epithelium

27

a2-agonists

APRACLONIDINE --> Decreased secretion of aqueous humor from the ciliary epithelium

28

Carbonic anhydrase inhibitors

ACETAZOLAMIDE
DORZOLAMIDE --> Decreased secretion of aqueous humor from the ciliary epithelium

29

Cholinomimetics

PILOCARPINE
PHYSOSTIGMINE --> Ciliary muscle contraction, opening of trabecular meshwork, increased outflow

30

Prostaglandins

LATANOPROST --> Increased outflow through canal of Schlemm

31

Nonselective
a-agonists

EPINEPHRINE --> Increased outflow via uveoscleral veins