Flashcards in Autonomic Pharmacology Deck (31):
Mnemonic:PLASMA (for parasympathetic nervous system):
Long preganglionic fibers
Short postganglionic fibers
Mnemonic: point and Shoot
Point (Erection) = Parasympathetic NS
Shoot (Ejaculation) = Sympathetic NS
B = Bethanechol = Bowel & Bladder Atony
What is Sjogren Syndrome?
autoimmune disorder characterized by triad of
-xerostomia (dry mouth)
-xerophthalmia (dry eyes)
What is myasthenia gravis?
autoimmune destruction of nicotinic ACh receptors, characterized by:
-proximal muscle weakness
Differentiate myasthenic crisis from cholinergic crisis.
-acute worsening of symptoms due to infection, stress or UNDERmedication
-excessive activation of cholinoceptors (skeletal muscle weakness and parasympathetic signs) due to OVERmedication
How does EDROPHONIUM differentiate myasthenic crisis from cholinergic crisis?
-IMPROVES muscle strength in myasthenic crisis
-WEAKENS muscle strength in cholinergic crisis
What are the signs and symptoms of organophosphate poisoning?
Excitation (skeletal muscle and CNS)
Mnemonics- Cycloplegia and Mydriasis
C=cycloplegia = Ciliary muscle paralysis = loss of Accomodation Mydriasis = Dilate (or you dilate your mouth when you say mydriasis)
Mnemonics-Muscarinic Antagonists for Parkinsonism
Try to Park your Benz, beep here.
Why is ipratropium the preferred bronchodilator in patients with comorbid COPD and heart disease?
-less likely to cause tachycardia and
-HOT as a hare
-DRY as a bone
-RED as a beet
-BLIND as a bat
-MAD as a hatter
Kapag nakapag-DEPOsit ka sa toilet, SUCCess yun. (DEPOlarizing = SUCCinylcholine)
dopamine vasoDILATES renal blood vessels while norepinephrine vasCONSTRICTS them
Mnemonic- Beta receptors
You have 1 heart and 2 lungs
B1 is for the heart, B2 is for the lungs
-acute heart failure
-increased cardiac output --> B1 and D1 agonists
maintenance of BP --> a1 agonist
muscle relaxation --> B2 agonist
decrease BP --> a2 agonist
What is the pharmacologic advantage of a1 sensitivity?
-reflex tachycardia is less common and less severe
ISOproterenol is NOT a beta blocker.
It is a nonselective beta agonist.
I SOrry! akala ko beta blocker ka!
Menmonics -Beta blockers with ISA
ISA PA! Isa pa! Isa pang CHICKEN JOY!
Intrinsic Sympathomimetic Activity = Pindolol, Acebutolol
NADOLOL=NAsa DOLO = longest half-life
ESMOLOL=ESMOL = short / small half-life
Treatment of Glaucoma
TIMOLOL --> Decreased secretion of aqueous humor from the ciliary epithelium
MANNITOL --> Decreased secretion of aqueous humor from the ciliary epithelium
APRACLONIDINE --> Decreased secretion of aqueous humor from the ciliary epithelium
Carbonic anhydrase inhibitors
DORZOLAMIDE --> Decreased secretion of aqueous humor from the ciliary epithelium
PHYSOSTIGMINE --> Ciliary muscle contraction, opening of trabecular meshwork, increased outflow
LATANOPROST --> Increased outflow through canal of Schlemm