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Flashcards in endocrine-parathyroid glands Deck (16)
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1

what cells secrete PTH

chief cells

2

what are 3 major functions of PTH

1. increase bone osteoclast activity-releasing Ca and phosphate
2. increase small bowel absorption of calcium and phosphate
3. increases renal calcium reabsorption (distal tubule) and decrease phosphate reabsorption (proximal tubule)

3

what is the most common cause of primary hyperparathyroidism

parathyroid adenoma

4

what type of nephrolithiasis would you see in primary parathyroidism

calcium oxalate stones

5

what is nephrocalcinosis

metastatic calfication of renal tubules potentially leading to renal insufficiency and polyuria

6

what are 3 GI side effects of primary parathyroidism that can be seen

constipation
peptic ulcer disease
acute pancreatitis

7

what is the following
" resorption of bone leading to fibrosis and cystic spaces"

osteitis cibrosa cystica

8

how are the following affected in primary parathyroidism
serum pth
serum ca
serum phosphate
urinary cAMP
serum alk phos

serum pth- increase
serum ca-increase
serum phosphate- decrease
urinary cAMP- increase
serum alk phos- increase

9

what is the most common cause of secondary parathyroidism?

chronic renal failure

10

how are the following affected in secondary hyperparathyroidism?
serum pth
serum ca
serum phosphate
serum alk phos

serum pth- increase
serum ca- decrease
serum phosphate- increase
serum alk phos- increase

11

what syndrome is associated with hypoparathyroidism

diGeorge syndrome

12

what are some presenting symptoms of hypoparathyroidism

related to low serum calcium
numbness and tingling
muscle spasms (tetany)- can be seen in trousseau sign or chvostek sign

13

what is trousseau sign

filling blood pressure cuff and you see muscle spasm

14

what is chvostek sign?

tapping of facial nerve causing muscle spasm

15

what is pseudohypoparathyroidism

hypocalcemia but with high PTH levels because of end organ resistance to PTH

16

what else can you see in auto dominant pseudohypoparathyroidism?

short stature and short 4th and 5th digits