Kidney - neoplasia Flashcards Preview

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Flashcards in Kidney - neoplasia Deck (20)
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1

What is an angiomyolipoma?

hamartoma composed of Bvs, SM, adipose tissue

2

What is the symptomatic triad in renal cell carcinoma?

hematuria, palpable mass, flank pain

3

Who is the typical person to get RCC?

male smoker in his 60s

4

What are some paraneoplastic syndromes typically involved in renal cell carcinoma?

inc EPO
inc renin
PTHrP
ACTH

5

What molecularly occurs in renal cell carcinoma?

loss of VHL - inc IGF1, inc HIF

6

If a person has VHL disease, what are they at risk for?

hemangioblastoma of the cerebellum, retinal angiomas, pheochromocytoma

7

Where does renal cell carcinoma like to spread to?

lungs and bones

8

What is a wilms tumor composed of?

blastema, primitive glomeruli, tubules, stromal cells

9

What mutation are wilms tumors associated with?

WT1

10

What are three syndromes associated with WT1 mutation?

1. WAGR syndrome
2. beckwith wiedemann syndrome
3. denys drash

11

What are the findings in WAGR syndrome?

W - wilms
A - aniridia
G - genital anomalies
R - mental retardation

12

What are the findings in beckwith wiedemann syndrome?

1. wilms
2. neonatal hypoglycemia
3. muscular hemihypertrophy
4. organomegaly - especially the tongue

13

What are the findings in denys drash syndrome?

1. wilms
2. intersexual disorders
3. glomerular mesangial sclerosis

14

What are some risk factors for urothelial carcinoma?

cig smoke - polycyclic hydrocarcbons, napthylamine
azo dyes
cyclophosphamide, phenacetin

15

How does urothelial carcinoma usually present?

painless hematuria in elderly people

16

Whats the difference btwn flat and papillary urothelial carcinoma?

flat automatically starts as high grade, whereas papillary starts as low grade

17

Where in the urinary tract does squamous cell carcinoma appear?

the bladder

18

What are risk factors for squamous cell carcinoma?

1. chronic cystitis
2. shistosoma hematobium
3. chronic nephrolithiasis

19

Where does adenocarcinoma typically occur in the urinary tract?

the bladder

20

What can adenocarcinoma arise from ?

urachal remnant - originally connects fetal bladder to yolk sac