Endocrine - thyroid neoplasia Flashcards Preview

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Flashcards in Endocrine - thyroid neoplasia Deck (16)
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1

What is seen on an iodine radioactive uptake study in:
1. graves
2. nodular goiter
3. adenoma
4. carcinoma?

inc uptake in graves and nodular goiter
dec uptake in adenoma and carcinoma

2

What is seen pathologically in a follicular adenoma?

benign proliferation of follicles surrounded by a capsule
-hemorrhage and fibrosis are common

3

What is the most common type of thyroid carcinoma?

papillary carcinoma

4

What is a major risk factor for papillary carcinoma?

exposure to ionizing radiation in childhood

5

What is seen pathologically in a papillary carcinoma?

nuclear grooves, somoma body, ground glass nuclei

6

How do you determine if a follicular mass is an adenoma or carcinoma? What test is not useful for this?

invasion of the capsule
-fine needle aspiration

7

Where do follicular carcinomas like to metastasize?

hematogenously to bones of shoulder, pelvis, sternum, skull

8

What mutation is responsible for a follicular carcinoma?

RAS oncogene or rearrangement of PAX8

9

What cells are involved in a medullary carcinoma?

parafollicular C cells

10

What is seen clinically with a medullary carcinoma?

hyperPTH, hypocalcemia, episodic htn

11

What is present in MEN2A?

medullary carcinoma, pheo, parathyroid adenoma

12

What is present in MEN2B?

medullary carcinoma, pheo, gangliomas of oral mucosa

13

What do the cells of a medullary carcinoma tend to express?

CEA

14

What is the appearance pathologically of a medullary carcinoma?

malignant cells in an amyloid stroma

15

What is an anaplastic carcinoma of the thyroid?

undifferentiated malignant tumor
sarcoma like proliferation of bizarre spindle, and giant cells

16

Who is anaplastic carcinomas usually seen in?

elderly women