Endocrine Pharm - First Aid Flashcards Preview

Endocrine/Repro > Endocrine Pharm - First Aid > Flashcards

Flashcards in Endocrine Pharm - First Aid Deck (25)
Loading flashcards...
1

What treatments are used for DM1?

Low sugar diet

Insulin replacement

2

What are treatment strategies for DM2?

Dietary modification and exercise

Insulin if lifestyle mod fails

3

What are the rapid acting insulins?

Lispro

Aspart

Glulisine

4

What is an intermediate acting insulin?

NPH

5

What are the long acting insulins?

Glargine 

Detemir

6

What is the result of Metformin? (3)

↓ gluconeogenesis

↑ glycolysis

↑ peripheral glucose uptake

**Lactic Acidosis - CI renal failure**

7

What are the first generation sulfonylrueas? What risks are associated with 1st gen sulfonylureas?

Tolbutamide & Chlorpropamide

Disulfiram-like effects

8

What are the 2nd generation sulfonylureas? What side effects are associated with?

Glyburide

Glimepiride

Glipizide

Hypoglycemia

9

How do sulfonylureas work?

Close K+ channel in β-cell - insulin release

10

What are the glitazones/thiazolidinediones? What are the side effects?

Pioglitazone and Rosiglitizone

Weight gain, edema, Htox, heart failure

11

How do glitazones/thiazolidinediones work?

Bind PPAR-γ nuclear transcription regulator

↑ insulin sensitity in peripheral tissue

12

α-glucosidase inhbitors

Acarbose

Miglitol

13

What are amylin analogs used for? What do they do?

Pramlintide

↓Gastric emptying ↓glucagon 

DM1 & DM2

14

GLP-1 analogs

↑Insulin ↓glucagon

DM2

15

What are the GLP-1 analogs? Besides N/V what is a possible complication?

Exenatide

Liraglutide

Pancreatitis

16

DPP-4 Inhibitors 

 

Sitagliptin

Saxagliptin

Linagliptin

Mild Urinary/repiratory infection

17

What does DPP-4 do?

Degrades GLP

18

What two drugs are used to treat hyperthyroidism?

Propylthiouracil - thyroid peroxidase and 5'deiodinase

Methimazole - thyroid peroxidase

19

What drug do you give to a pregnant woman with hyperthyroidism?

PTU

Methimazole is a possible teratogen - aplasia cutis

20

What side effect can PTU cause?

Hepatotoxicity

21

What 2 drugs are used in hypothyroidism and myxedema?

Levothyroxin

Triiodothyronine

22

What two diseases would you treat with GH? 

GH deficiency

Turner Syndrome

23

What disease do you treat with octreotide?

Acromegaly

Carcinoid

Gastrinoma 

Glucagonoma

Esophageal varices 

24

What does oxytocin do?

Stimulates labor, uterine contractions

MIlk let down

Controls uterine hemorrhage

25

Demeclocycline

ADH antagonist

SIADH