What treatments are used for DM1?
Low sugar diet
What are treatment strategies for DM2?
Dietary modification and exercise
Insulin if lifestyle mod fails
What are the rapid acting insulins?
What is an intermediate acting insulin?
What are the long acting insulins?
What is the result of Metformin? (3)
↑ peripheral glucose uptake
**Lactic Acidosis - CI renal failure**
What are the first generation sulfonylrueas? What risks are associated with 1st gen sulfonylureas?
Tolbutamide & Chlorpropamide
What are the 2nd generation sulfonylureas? What side effects are associated with?
How do sulfonylureas work?
Close K+ channel in β-cell - insulin release
What are the glitazones/thiazolidinediones? What are the side effects?
Pioglitazone and Rosiglitizone
Weight gain, edema, Htox, heart failure
How do glitazones/thiazolidinediones work?
Bind PPAR-γ nuclear transcription regulator
↑ insulin sensitity in peripheral tissue
What are amylin analogs used for? What do they do?
↓Gastric emptying ↓glucagon
DM1 & DM2
What are the GLP-1 analogs? Besides N/V what is a possible complication?
Mild Urinary/repiratory infection
What does DPP-4 do?
What two drugs are used to treat hyperthyroidism?
Propylthiouracil - thyroid peroxidase and 5'deiodinase
Methimazole - thyroid peroxidase
What drug do you give to a pregnant woman with hyperthyroidism?
Methimazole is a possible teratogen - aplasia cutis
What side effect can PTU cause?
What 2 drugs are used in hypothyroidism and myxedema?
What two diseases would you treat with GH?
What disease do you treat with octreotide?
What does oxytocin do?
Stimulates labor, uterine contractions
MIlk let down
Controls uterine hemorrhage