Flashcards in Female Devo Deck (58)
What are the 3 parts of the reproductive section
3. External Genetalia
Sex determinations occurs at ___________.
Sex differentiation occurs during which period? What is if influenced by?
Embryonic Period into the Fetal Period
Genetic and Epigenetic factors
Presence and action of what actively influence sexual differentiation in the male direction?
What is the 2nd factor is involved in promoting regression of Mullerian ducts?
Mullerian Inhibiting Factor
What two general categories contribute to the reproductive organs?
Endoderm and intermediate mesoderm
During development the forming reproductive organs pass through a unique intermediate phase termed the _______________.
Indifferent stage - genetically determined, sexually undifferentiated
The gonad primordium is a morphologically distinct part of the _______________.
With the appearance of the gonad primordium, the ridge is renamed ____________.
The UG ridge
What are the cell types found in forming gonads? (3)
Supporting cells - Sertoli or Follicle
Interstitial cells - Leydig/Interstitial cells
Where do the primordial germ cells (gamete progenitor cells) come from?
Yolk sac - first place we view them
Migrate to gonad
The primordial germ cells travel via what structure to get to the gonad?
Germ cells that get lost on migration become what?
The primitive gonad develops cranial and caudal attachments - what do these become?
Cranial - suspensory ligament/spermatic cord
Caudal - gubernaculum
The mesonephric duct is also known as what?
The Wolffian System - associated w/ mesonephric kidney
The paramesonephric duct is also known as what? What induces its formation?
The Mullerian System
Induced by Mesonephric Duct
What are the progenitors of the externa genitalia? (3)
External swellings in the caudal region
Labioscrotal swellings - lateral to UG folds
What 3 things result at the end of the indifferent stage?
1. A pair of of undifferentiated gonads
2. 2 sets of ducts - Mesonephric and Paramesonephric
3. Elevations and folds around the opening of the UG sinus
Expression of what gene makes a male?
SRY gene on Y chromosome - encodes for the DNA binding protein Testicular Determining Factor
What is the outcome of SRY expression?
1. PGC form spermatogonia
2. Sertoli cells express Sox9, form seminiferous cords
3. Leydig cells secrete testosterone (wk 8)
What causes the gonad to develop into an ovary?
Absence of SRY gene - WNT4 is expressed in coelomic epithelial cells - 2 X Chromosomes needed for ovarian development
WNT4 inhibits the expression of ____ and visa versa.
The testis descend into the ______ usually before _______. Failure results in what?
In the presence of _______ the growth and differentiation of the mesonephric ducts are supported.
What are derivatives of the mesonephric duct?
1. Duct of epididymis
2. Ductus (vas) deferens
3. Ejaculatory ducts
4. Seminal vesicle
What are the derivatives of the mesonephric tubules?
What is the origin of the prostate gland?
Central zone glands: Mesoderm - mesenteric duct
Most glands: form from buds of the endoderm lining in the pelvic part of UG sinus
Budding of the prostate glands is induced by what?
UG sinus mesenchyme
Presence of _____ in male embryos stimulates the regression of the paramesonephric ducts?
Mullarian Inhibiting Substance