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Flashcards in Female Devo Deck (58)
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1

What are the 3 parts of the reproductive section

1. Gonads
2. Ducts
3. External Genetalia

2

Sex determinations occurs at ___________.

Fertilization

3

Sex differentiation occurs during which period? What is if influenced by?

Embryonic Period into the Fetal Period
Genetic and Epigenetic factors

4

Presence and action of what actively influence sexual differentiation in the male direction?

Androgens

5

What is the 2nd factor is involved in promoting regression of Mullerian ducts?

Mullerian Inhibiting Factor

6

What two general categories contribute to the reproductive organs?

Endoderm and intermediate mesoderm

7

During development the forming reproductive organs pass through a unique intermediate phase termed the _______________.

Indifferent stage - genetically determined, sexually undifferentiated

8

The gonad primordium is a morphologically distinct part of the _______________.

Nephrogenic cord

9

With the appearance of the gonad primordium, the ridge is renamed ____________.

The UG ridge

10

What are the cell types found in forming gonads? (3)

Germ cells
Supporting cells - Sertoli or Follicle
Interstitial cells - Leydig/Interstitial cells

11

Where do the primordial germ cells (gamete progenitor cells) come from?

Yolk sac - first place we view them
Migrate to gonad

12

The primordial germ cells travel via what structure to get to the gonad?

Dorsal mesentary

13

Germ cells that get lost on migration become what?

Teratoma

14

The primitive gonad develops cranial and caudal attachments - what do these become?

Cranial - suspensory ligament/spermatic cord
Caudal - gubernaculum

15

The mesonephric duct is also known as what?

The Wolffian System - associated w/ mesonephric kidney

16

The paramesonephric duct is also known as what? What induces its formation?

The Mullerian System
Induced by Mesonephric Duct

17

What are the progenitors of the externa genitalia? (3)

External swellings in the caudal region
Genital tubercle
Urethral/UG folds
Labioscrotal swellings - lateral to UG folds

18

What 3 things result at the end of the indifferent stage?

1. A pair of of undifferentiated gonads
2. 2 sets of ducts - Mesonephric and Paramesonephric
3. Elevations and folds around the opening of the UG sinus

19

Expression of what gene makes a male?

SRY gene on Y chromosome - encodes for the DNA binding protein Testicular Determining Factor

20

What is the outcome of SRY expression?

1. PGC form spermatogonia
2. Sertoli cells express Sox9, form seminiferous cords
3. Leydig cells secrete testosterone (wk 8)

21

What causes the gonad to develop into an ovary?

Absence of SRY gene - WNT4 is expressed in coelomic epithelial cells - 2 X Chromosomes needed for ovarian development

22

WNT4 inhibits the expression of ____ and visa versa.

Sox9

23

The testis descend into the ______ usually before _______. Failure results in what?

Scrotum
Birth
Cryptorchidism

24

In the presence of _______ the growth and differentiation of the mesonephric ducts are supported.

Testosterone

25

What are derivatives of the mesonephric duct?

1. Duct of epididymis
2. Ductus (vas) deferens
3. Ejaculatory ducts
4. Seminal vesicle

26

What are the derivatives of the mesonephric tubules?

Efferent ductules

27

What is the origin of the prostate gland?

Central zone glands: Mesoderm - mesenteric duct
Most glands: form from buds of the endoderm lining in the pelvic part of UG sinus

28

Budding of the prostate glands is induced by what?

UG sinus mesenchyme

29

Presence of _____ in male embryos stimulates the regression of the paramesonephric ducts?

Mullarian Inhibiting Substance

30

In the absence of ______ the development of the mesonephric ducts is not supported.

Testosterone