Endocrine pharma

Question 1

Thoanamides. Mist adverse drug reaction

Answer 1

Angranulocytosis

Question 2

Drug of choice for hyperthyroidism

Answer 2

Methi azole

Question 3

Used to monitor adequacy of treatment of hypothyroisim

Answer 3

Tsh

Question 4

To monitor adequacy of hyoerthyroidism

Answer 4

Free t4

Question 5

Most important test to in toxic nodular goiter

Answer 5

Tsh. Then if tsh is low, scan. If tsh is normal, biopsy

Question 6

Inhibits release of preformed thyroid hormones

Answer 6

Lithium

Question 7

Most common side effect of thionamide

Answer 7

Rash. King walang rash, pruritius.

Question 8

Course of action to agranulocytosis sec to methimazole

Answer 8

Discontinue methimazole. Used drug from a different class.

Question 9

level of tsh in subclinical hypothyroisdism asymptomatic that you need to treat

Answer 9

10

Question 10

Which among glucocorticoids is long acting

Answer 10

Fluorinated derivatives. Dexa, beta, triamcinolone. No/low mineralocorticoid activity. Used in cerebral edema. Strong anti inflammatory potency. Thus can cause high blood sugar levels.

Question 11

Quick acting glucocorticoids, needed for its mineralocorticoid potency

Answer 11

Cortisone, hydrocortisone. Low inflammatory potency.

Question 12

Preferred glucocorticoid for opd treatment of asthma

Answer 12

Methylprednisone. Kung wala, prednisone.

Question 13

Used for primary aldosteronism. A mineralocoticoid antagonist. Androgen antagonist, used for treatment of hirsutism, optimal effects are seen from 2 to 6 months.

Answer 13

Spironola tone

Question 14

Problems with spironolactone

Answer 14

Can develop gynecomastia

Question 15

Mineralocorticoid antagonist used as replacement for spironalctone in treatment of hypertension

Answer 15

Eplerenone

Question 16

Bone resorption is stimulated by

Answer 16

Pth (constant), cortisol, thyroid hormone, prostaglandin

Question 17

Bone formation is stimulated by

Answer 17

Pth (intermittently given), Gh, insulin, estrogen, androgen, vitamin d, calcitonin

Question 18

Bone for ation is inhibited by which hormone

Answer 18

Cortisol

Question 19

Bone resorption is inhibited by

Answer 19

Estrogen, androgen, calcitonin, NItric oxide

Question 20

Tretament of osteporosis. Most potent anti catabolic drug

Answer 20

Biphosphonates. Alendronante. Risendronante.

Question 21

The only true anabolic drug for treatment of osteoporosis. Most important anabolic drug for osteoporosis.

Answer 21

Pth. Teriparatide.

Question 22

Adverse effect of teriparatide. Anabolic drug for osteoporosis.

Answer 22

Osteosarcoma

Question 23

Adverse effect of bisphosphonates

Answer 23

Esophagitis (most common). Osteonecrosis (most life thretening)

Question 24

Best drug to give for pain sec to osteoporosis

Answer 24

Calcitonin

Question 25

Most ammount of calcium (carbonate or citrate)

Answer 25

Calcium carbonate

Question 26

Required calcium intake for average adult

Answer 26

1000mg/day

Question 27

Required calcium intake for elderly

Answer 27

1200 mg/day

Question 28

Rank is found in what cell

Answer 28

Osteoclast

Question 29

Rankl is found in what cell

Answer 29

Osteoblast

Question 30

First rankl inhibitor for treatment of osteoporosis.

Answer 30

Denosumab.

Question 31

T or F. Rapid acting insulins are designed to mimic endogenous insulin kinetics

Answer 31

T

Question 32

Soluble insuline. Can be mixed in iv preparations.

Answer 32

Regular and rapid acting insulin

Question 33

Insulin that is acidic

Answer 33

Glargine

Question 34

Insulin approved for pregnant women

Answer 34

Rapid short acting and intermediate

Question 35

Inhaled insulin

Answer 35

Mannkind afrezza (new drug)

Question 36

Oral anti diabetic. Incresease i sulin secretion.

Answer 36

Secretagougues. Sulfonylureas and megletinides. (SUM)

Question 37

Most potent oral anti diabetic

Answer 37

Sulfonylureas and biguanides

Question 38

Incretin

Answer 38

Intestinal secretion of insulin

Question 39

Incretin. Moa

Answer 39

Provide more glp-1. (Exenatide and liraglutide = glp-1 agonist).

Question 40

Gliptins. Moa

Answer 40

Inhibits the degradation of glp-1. Thereby increasing blood levels, increase the insulin secretion.

Question 41

- Glifozins. Sglt-2 transporter inhibitors. Sodium glucose co transporter-2. Moa.

Answer 41

Facilitates "spilling" of glucose to the urine. Glucosuria. Glucosuria prone to urinary infection.

Question 42

Most potent sulfonylureas

Answer 42

Glibenclamide (2nd gen sulfonylurea)

Question 43

Most common adverrse drug of sulfonylurea

Answer 43

Hypoglycemia (most common). Pag wala, weight gain. | Bone marrow suppression (most life threatening)

Question 44

Drugs that causes Glucose dependent insulin sevretion

Answer 44

- Gliptins. (Incretins)

Question 45

Drugs that causes glucagon secretion.

Answer 45

Metformin and gliptins

Question 46

Inhibi tion of peripheral conversion of t4 to t3

Answer 46

Dexamethasone, propylthiouracil. Propanolol