Sex hormones

Question 1

Moa of coc

Answer 1

Estrogenic suppresses fsh secretion
Progestrogenic suppresses lh secretion
Suppresses gonadotropin secretion

Question 2

Thromboembolism is associated in excess of oral contraceptive

Answer 2

Estrogen

Question 3

Estrogenic compound useful for postmenopausal supplementation

Answer 3

Chlorotrianesene

Question 4

Anti androgen with moa of inhibition of androgen synthesis

Answer 4

Leuprolide

Question 5

Anti hypertensive medication safe for pregnancy

Answer 5

Methyldopa

Question 6

Drug used for acid peptic disease now used as abortifacient

Answer 6

Misoprostol

Question 7

T or F: gnrh is released in pulses which is critical inhpa axis

Answer 7

True

Question 8

Testosterone synthesis is done in which cell

Answer 8

Leydig cell

Question 9

Testosterone binds in androgen binding protein inwhich cell

Answer 9

Sertoli cell

Question 10

Converts androgen to estrogen

Answer 10

Aromatase

Question 11

Hormone that associated with sertoli cell, spermatogenesis and increased abp production

Answer 11

Fsh

Question 12

Hormone assoc with granulosa layer and increased aromatase activity

Answer 12

Fsh

Question 13

Hormone assoc with leydig cell and testosterone production

Answer 13

Lh

Question 14

Hormone assoc with theca cells and androgenestenedione synthesis

Answer 14

Lh

Question 15

Effect of estrogen in basal body temperature

Answer 15

None. Progesterone has the effect of increased basal body temp

Question 16

After ovulation, this hormone increases

Answer 16

Progesterone

Question 17

Responsible for secretory cycle

Answer 17

Progesterone

Question 18

T or F: after ovulation, what endometrial phase?

Answer 18

Secretory phase

Question 19

Responsible for proliferative phase of endometrium

Answer 19

Estrogen

Question 20

Major natural estrogen in humans

Answer 20

Estradiol

Question 21

Synthetic estrogens

Answer 21

Ethynyl estradiol

Question 22

Non steroidal synthetic estrogen

Answer 22

Diethylstilbesterol

Question 23

Estrogen effects on bone

Answer 23

Decreases bone resorption. Prone to osteoporosis.

Question 24

Non steroidal synthetic estrogenic drug that asso with vaginal carcinoma in female offspring

Answer 24

DES.

Question 25

Stimulates growth and development of the breast alveoli during pregnancy

Answer 25

Progesterone

Question 26

Duct proliferation in breast

Answer 26

Estrogen

Question 27

Most potent natural estrogen

Answer 27

Estradiol

Question 28

Contraceptive pill that should be taken everyday at the same time

Answer 28

Progestin only pills. Benefits. Has no effect in milk production. Not prone to thrombosis

Question 29

Hot flushes. Mens irregularity, sweating, insomnia

Answer 29

Early symptoms of menopause

Question 30

Example of a selective estrogen receptor antagonist

Answer 30

Tamoxifen,

Question 31

Competitive partial aginist inhibitor of estrogen

Answer 31

Serm, tamoxifen

Question 32

Serm that is antagonistic in breast

Answer 32

Tamoxifen. Agonist in bone cardiovascular and uterus. Prone to endometrial ca.

Question 33

Apserm antagonistic to breast uterus bone and cardiovascular

Answer 33

Clomiphene. Used for ovulation induction. But with thin endometrium, might have problems in implantation.

Question 34

Pure estrogen receptor antagonist

Answer 34

Fulverstrant. PUre. FUlvestrant

Question 35

Used in inhibiting growth of estrogen dependent tumor, ex. Breast ca

Answer 35

Aromatase inhibitors. May be used as an off label ovulating agent.

Question 36

Estrogen synthesis inhibitor that Inhibits cytochrome p450 enzymes

Answer 36

Danazol

Question 37

Continues release of gnrh will result to

Answer 37

Suppresses, rather than stimulates, pituitary gonadotropin secretion. No fsh, no lh, no androgen. (Gnrh agonist)

Question 38

Ovulation induction drugs

Answer 38

Clomiphene (serm). Letrozole off label use (aromatase inhibitors)

Question 39

inhibits conversion of testosterone to dihydrotesyosterone

Answer 39

5-alpha reductase inhibitor. Finasteride. (FIve = FInasteride). Used for benign prostatic hyperplasia.

Question 40

Flutamide.

Answer 40

For prostate cancer. Androgen receptor inhibitor.

Question 41

Antifungal drug used as androgen synthesis inhibitor

Answer 41

Ketoconazole

Question 42

Progesterone receptor antagonist. Give example.

Answer 42

Mifeprestone.

Question 43

Susceptible to teratogenic effect. Period of development.

Answer 43

Embryonic period.

Question 44

Immune to teratogenic effects. Period of development

Answer 44

Pre embryonic. First 2 weeks.

Question 45

Category A drug.

Answer 45

No increased risk for fetal abnormalities, during all trimesters of pregnancy. Folic acid. Thyroid hormones

Question 46

Category D drug.

Answer 46

Fetal harm in administration BUT if needed the patient should be informed of the effects of the drug on the fetus. Benzodiazepines

Question 47

Category X. Contraindicated in pregnancy.

Answer 47

Oral contraceptive pills.

Question 48

Secreted by posterior pituitary gland and elicits milk ejection and uterine contractions

Answer 48

Oxytocin

Question 49

Ergot alkaloid that used only for control of late uterine bleeding. Not give before delivery, causes prolonged powerful uterine spasm. Used if oxytocin is not effective to control postpartum hemorrhage.

Answer 49

Methylergometrine. Methergine.

Question 50

Estrogen used in most combined oral contraceptives

Answer 50

Estradiol