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MRCP > Endocrinology > Flashcards

Endocrinology Flashcards

1
Q

Typical blood biochemistry of hypoparathyroidism

A

Elevated phosphate, low calcium and normal alkaline phosphatase

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2
Q

Definitive diagnostic test for Sjogren’s

A

Labial gland biopsy

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3
Q

What thyroid carcinoma is very fast growing and often results in stridor

A

Anaplastic thyroid carcinoma

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4
Q

What is does RET pro onco gene code for

A

Encodes a receptor for tyrosine kinase . Associated with MEN2 - medullary thyroid carcinoma, bilateral phaeochromocytoma and primary hyperparathyroidism

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5
Q

What syndrome is associated with bilateral inguinal hernias

A

androgen insensitivity syndrome . breasrt formation is normal due to peripheral androgen conversion, pubic hair is absent

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6
Q

What are the features of Kallmann syndrome

A

Delayed puberty and impaired smell

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7
Q

What genetic disease is associated with short stature, webbed neck and primary amenorrheoa

A

Turner sydnrome

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8
Q

Is MEN1 AD or AR?

A

AD

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9
Q

What tumours occur with MEN syndrome

A

parathyroid, pancreatic and pituitary

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10
Q

What is associated with phaeochromocytoma, haemangioblastoma and increased risk renal cancer

A

von hippel lau syndrome

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11
Q

What are the causes of cranial diabetes insipidus

A

sarcoidosis, head injury, GPA and langerhans’ cell histiocytosis

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12
Q

What is characterised by raised urinary calcium levels, hypokalaemia, metabolic alkalosis and raised renin and aldosterone levels

A

bartlett’s

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13
Q

What causes a transient hyperthyroidism followed by hypothyroidism in context flu like illness

A

de quervains thyroiditis

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14
Q

What diuretic has a negative effect on progression to diabetes in people with impaired fasting glucose

A

thiazides

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15
Q

Gitleman’s syndrome what is metabolic abnormality

A

Hypokalaemia, metabolic alkalosis and hypocalcinuria

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16
Q

What is difference between liddle syndrome and conn’s

A

Liddl has low RAS levels, conn’s has high levels. Both present with hypertension, hypokalaemia and metabolic alkalosis

17
Q

What cancer is associated with MEN2 syndrme

A

medullary cancer of thyroid, phaeochromocytoma and hyperparathyroidism

18
Q

What is screening test for carcinoid syndrome

A

5HIAAA urine 24hr collection

19
Q

What is McCune Albright syndrome

A

polyosteotic fibrous dysplasia, cafe au lait hyperpigmemtation and autonomic endocrine hyperfunction

20
Q

Is androgen insensitivity associate with male or female phenotype

A

Female

21
Q

What is the metabolic abnormality seen with hyperparathyroidism

A

high calcium low phosphate raised alk phos

22
Q

What cardiac defect is associated with turner’s syndrome

A

Co-arctation of the aorta

23
Q

How do craniopharyngiomas present

A

with diabetes insipidus

24
Q

Which HLA subtype is most associated with AI thyroid disease and T1 diabetes

A

HLA DR3. HLA B47 asssociated with CAHyperplasia. HLA B27 associated with seronegative arthropathies, HLA A28 schizophrenia and HLA DR7 nephrotic syndrome

25
Q

what is the prokinetic of choice in treating diabetic gastroparesis

A

domperidone

26
Q

Can cushions cause dyslipidaemia yes or no

A

Yes

27
Q

Which lipids are raised in familial combined hyperlipidaemia

A

Ldl and triglycerides

28
Q

What is raised in familial hypercholesterolaemia

A

LDL cholesterol

29
Q

what is erythema gratum repens associated with ?

A

bronchial carcinoma
(wood gain rash apperance)

30
Q

what HLA is takayasu associated with?

A

HLA B
52

31
Q

what HLA is bechet’s associated with

A

HLA B51

32
Q

pharmacological treatment of prolactinoma

A

cabergoline (dopamine agonist)
also bromocriptine

33
Q

tx of acromegaly

A

somatostatin analogue eg octreotide or growth hormone antagonist eg pegvisomant

34
Q
A
35
Q

why is benzbromarone preferred to feboxustat?

A

feboxystat linked to excess CV mrtality

36
Q

3 x examples of antigen presenting cells

A

B cells, macrophages and dendritic cells

37
Q
A
38
Q

How long since LMP before starting continuous HRT

A

2 years

MRCP (14 decks)

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