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MRCP > Rheumatology > Flashcards

Rheumatology Flashcards

1
Q

Which antibodies in SLE are associated with neonatal heart block

A

anti Ro

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2
Q

mechanism of action of tocolizumab

A

I’ll 6 inhibitor

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3
Q

MOA rituximab

A

anti CD20

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4
Q

name a ctla4 Ig

A

abatacept

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5
Q

what is main killing mode for neutrophils

A

phagocytosis through opsonisation

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6
Q

what is mainstay of treatment in dermatomyositis

A

prednisolone. anti mi 2 antibodies

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7
Q

antibodies in polymyositis

A

anti jo

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8
Q

Treatment of GPA

A

cyclophosphamide

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9
Q

Antibodies in GPA

A

Anti Pr3 (c-anca)

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10
Q

Sx of GPA

A

Sinusitis then collapse nasal bridge

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11
Q

Treatment GPA

A

High dose corticosteroids then cyclophosphamide

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12
Q

Antibodies for microscopic polyangitis

A

MPO
pANCA

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13
Q

Chrug strouss, PANCA or cANCA

A
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14
Q

Tx psoriasis with a) skin involvement b) without

A

A) Methotrexate
B) SSZ

Etanercept (tnfalpha) if inefficient

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15
Q

Felty syndrome?

A

Ra, neutropenia, splenomegaly

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16
Q

Antibodies for GPA

A

PR3 (cANCA)

17
Q

Use of anti il-2

A

renal cell carcinoma

18
Q

Example of il-6 inhibitor

A

Tocoluzimab

19
Q

Antibody in polymyositis

A

Anti Jo

20
Q

Antibody in PBC

A

ANTI MITOCHONDRIAL

21
Q

Ab in AI HEPSTITIS

A

ANTI smooth muscle

22
Q

What is c anca associated with

A

gpa

23
Q

What is p anca associated with

A

eGPA, PSC

24
Q

What worsens graves eye disease

A

Radioiodine

25
Q

Anti lmk-1 antibodies

A

T2 AI hepatitis

26
Q

Anti mitochondrial antibodies

A

Primary biliary cholangitis

27
Q

Anti topoispmerase (anti scl-70)

A

Systemic sclerosis

28
Q

Symptoms of behcets (x3)

A

Genital ulceration
Uveitis
Oral ulceration

29
Q

Tx of bechets

A

Prednisone
Azathioprine steroid sparing

30
Q

How does cinacalcet reduce calcium in teriary hyperparathyroidism

A

Cinacalcet directly lowers parathyroid hormone levels by increasing the sensitivity of the calcium sensing receptors to activation by extracellular calcium, resulting in the inhibition of PTH secretion.

31
Q

What can be used as tumour marker for medullary thyroid cancer

A

Calcitonin

32
Q

what DMARD for psoriatic arthritis

A

methotrexate
SSZ alternative when not tolerated
TNF alpha when at least one DMARD attempted eg etanercept

33
Q

lupus nephritis treatment

A

Mycophenolate mofetil

34
Q

tx of idiopathic membranous nephropathy with worsening prteinuria and renal function

A

cyclophosphamide and pred

35
Q

what associated disease is anti scl70 associated with (in addition to diffuse sclerosis)

A

pulmonary fibrosis

ANA is very sensitive but not specific

RNA polymerase III associated with skin involvement

36
Q
A
37
Q

Anti Jo ABs

A

Polymyositis

38
Q

Anti mi 2

A

Dermatomyositis

39
Q

Tx reactive arthritis

A

NSAIDS
then steroids

MRCP (14 decks)

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