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Flashcards in endocrinology lectures -- settles Deck (59)
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1

this hormone is iodine containing

thyroid hormone

2

T/F
T4 is greater than T3 in activity

FALSE

3

which is the active form
T4 or T3

T3

4

primary hypothyroidism is a disease of what tissue and accounts for what percent of hypothyroid cases?

thyroid gland - bc primary disease

95% of cases

5

most of the primary hypothyroid cases are due to what?

lymphocytic thyroiditis -- autoimmune disorder

6

these 4 drugs can cause a low T4

􏰍 Glucocorticoids
􏰍 Carprofen
􏰍 Furosemide
􏰍 Phenobarbital

7

what are 3 iatrogenic causes of low T4

􏰍 I131
􏰍 Antithyroid drugs
􏰍 Thyroidectomy

8

T/F
the signalment for a hypothyroid dog is a really young small breed dog

FALSE -- large breed middle aged dogs

9

middle aged dog with lethargy, alopecia, hyperpigmentation, rat tail and seborrhea are all clinical signs pointing towards what endocring disorder

Hypothyroidism

10

T/F
alopecia in a hypothyroid dog will be bilaterally symmetric

TRUE -- endocrine disorders are all this way

11

deposition of mucopolysaccharides in the dermis leading to a sad facial expression is known as

myxedema

12

myxedema is seen in what endocrine disorder

hypothyroid dogs

13

this "syndrome" will give low T4 results while everything else remains normal

euthyroid sick syndrome

14

pituitary gland secretes this to stimulate the thyroid

TSH

15

the hypothalamus secretes this to stimulate the pituitary to release TSH

TRH

16

Lab results of a thyroid panel for a primary hypothyroid dog

Low T4, low FT4, HIGH TSH

17

T/F
TSH will be low for primary hypothyroidism

FALSE -- will be HIGH

18

secondary hypothyroidism is an issue with what tissue

the pituitary

19

what will the lab results for a secondary hypothyroidism dog be

LOW T4, low FT4, LOW TSH

20

what happens to the cholesterol and trigs during hypothyroidism

they go up
hypercholesterolemia

21

T/F
if you get a normal T4 reading back on lab work you can rule out hypothyroidism

TRUE

22

what is the gold standard test for dx of primary hypothyroidism

TSH stimulation test

23

what is the synthetic T4 drug of choice for treating hypothyroidism

levothyroxine

24

when treating hypothyroid dogs, after how many weeks will the attitude be improved

1-2 weeks

25

when treating hypothyroid dogs, after how many weeks will the derm be improved

4-6 weeks

26

when treating hypothyroid dogs, after how many months will the hair growth be improved

2-3

27

cat with these clinical signs:
Decreased fur on temples & pinnae, wt gain

hypothyroid cat

28

what will be the results of a TSH stimulation test in a hypothyroid dog

no significant increase in post-T4 (due to thyroid gland atrophy or destruction)

in a normal dog there would be an increase

29

most common cause of hyperthyroidism in cats

functional adenoma

30

old thin cat differentials

renal dz
lymphoma
inflammatory bowel dz
hyperthyroid

31

average age for a cat with hyperthyroidism

12

32

most common endocrinopathy of cats

hyperthyroidism

33

clinical signs of a cat with hyperthyroidism

scraggly coat (lol)
pu/pd -- dilute urine
vomiting
diarrhea
goiter
tachycardia

34

how to treat tachycardia from hyperthyroidism

beta blockers like propanolol -- thyroid works toward the beta receptors so small doses of propranolol can slow the heart rate and lower BP

35

when palpating a hyperthyoid cats thyroid why is it important to go slowly

to prevent a thyroid storm

36

T/F
cats have an inducible form of Alk phos

FALSE -- so this will be increased in hyperthyroid cats

37

in a hyperthyroid cat's serum chemistry, will the ALT be higher, lower, or unchanged

HIGHER

38

T/F
hypothyroid dogs have PU/PD

FALSE

39

why is the azotemia in a hyperthyroid cat masked

the higher BP from the thyroid keeps the GFR up and so the azotemia is not noticed -- this is still causing damage to the kidney over time and is bad

40

ideal treatment for hyperthyroid cat

30 days methimazole -- see if azotemia is unmasked first and treat the kidney issues
THEN I131

good prognosis ^^ +5.3yrs

41

this drug acts by inhibiting thyroid hormone synthesis by
blocking incorporation of iodine

methimazole (tapazole) -- hyperthyoid cat tx

42

Excess glucocorticoids produced by adrenals.  

hyperadrenocorticism -- cushings disease

43

which thyroid hormone can be absorbed across the cell membrane

free T4

44

When treating a hypothyroid dog when should blood levels be drawn to evaluate therapy?
a. 4-6 hours post pill after 1 month of treatment if the dog is on BID therapy
b. 4-6 hours post pill after 2 weeks of treatment if the dog is on q24 hour treatment
c. 8-12 hours post pill after 1 month of treatment if the dog is on BID therapy
d. Peak and trough levels should be drawn after 1 month of therapy

a. 4-6 hours post pill after 1 month of treatment if the dog is on BID therapy

45

What is the most appropriate test to differentiate pituitary dependent from adrenal dependent hyperadrenocorticism

abdominal ultrasound

46

The following signs are most consistent with which disease?
Polyuria, Pot-bellied, Polydipsia, Polyphagia, Panting

hyperadrenocorticism -- cushings

47

Which of the following helps to differentiate Cushing’s disease from hypothyroidism in dogs?
a. Low Total T4 with hypercholesterolemia
b. Polyuria/ polyphagia
c. Obesity and hair loss
d. Elevated ALP and weight loss

B

48

differentials for PU/PD

Pyelonephritis
Hypercalcemia
Diabetes mellitus
Drugs
Liver disease

49

Which of the following is most consistent with HAC?
a. Stress leukogram, Elevated ALP, USG = 1.012
b. Mild neutrophilia, Elevated ALT, USG = 1.020
c. Mild anemia, Elevated Creatinine, USG = 1.012
d. Mild anemia, Elevated ALP, USG = 1.045

A

50

Which of the following is most consistent with a diagnosis of Cushing’s disease?
a. An elevated UCC and normal ACTH stim
b. A borderline UCC and an elevated LDDS at 8 hours
c. A low HDDS at 8 hours with an elevated UCC
d. An elevated endogenous ACTH level

B

51

What if the LDDS came back as positive for Cushing’s but not definitive for PDH? What is the best answer?
a. Abdominal ultrasound
b. HDDS
c. Endogenous ACTH
d. ACTH stim

Abdominal ultrasound

52

form of hyperadrenocorticism that Causes bilateral adrenocortical hyperplasia

Pituitary dependent -- accounts for 80-85% of cases and mostly small breed dogs

53

what will iatrogenic cushings do to the adrenal glands

bilateral atrophy

54

calcinosis cutis is seen in what endocrine disorder

cushings

55

destroys zonae fasciculata and reticularis of adrenal gland – permanent adrenal atrophy

mitotane - lysodren

56

Selective and irreversible inhibitor of monoamine oxidase type B, helps restore central dopamine concentration and facilitates dopaminergic transmission

selegiline - anipryl

57

Use in those patients whose owners do not want to use Lysodren for fear of its side effects or cost of Trilostane

selegiline

58

Synthetic, orally active steroid analog; competitive inhibitor of the 3-􏰃-hydroxysteroid dehydrogrenase enzyme system thereby inhibiting synthesis of several steroids including cortisol and aldosterone

Trilostane

59

Imidazole antifungal drug, lowers circulating cortisol concentrations by inhibiting steroid biosynthesis

ketoconazole